4-Chloro-2-(4-chlorobenzoyl)-1-(4-Methoxyphenyl)hydrazide Benzoic Acid

4-Chloro-2-(4-chlorobenzoyl)-1-(4-Methoxyphenyl)hydrazide Benzoic Acid Structure
CAS No.
402849-27-8
Chemical Name:
4-Chloro-2-(4-chlorobenzoyl)-1-(4-Methoxyphenyl)hydrazide Benzoic Acid
Synonyms
Indomethacin Impurity F;Indometacin Impurity 14;Indapamide EP Impurity F;Indomethacin EP Impurity F;Indometacin EP Impurity F;Indometacin (Indomethacin) EP Impurity F;Indomethacin (Indometacin) EP Impurity F;Indomethacin Impurity 6(Indomethacin EP Impurity F);4-Chloro-N''-(4-chlorobenzoyl)-N-(4-methoxyphenyl)benzohydrazide;4-Chloro-2-(4-chlorobenzoyl)-1-(4-methoxyphenyl)hydrazide Benzoic Acid
CBNumber:
CB32695340
Molecular Formula:
C21H16Cl2N2O3
Molecular Weight:
415.27
MOL File:
402849-27-8.mol
Modify Date:
2023/4/23 13:52:06

4-Chloro-2-(4-chlorobenzoyl)-1-(4-Methoxyphenyl)hydrazide Benzoic Acid Properties

Melting point 159-163°C
Density 1.370±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility Chloroform (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly, Soncited)
pka 9.41±0.46(Predicted)
form Solid
color White to Pale Beige

4-Chloro-2-(4-chlorobenzoyl)-1-(4-Methoxyphenyl)hydrazide Benzoic Acid Chemical Properties,Uses,Production

Uses

4-Chloro-2-(4-chlorobenzoyl)-1-(4-Methoxyphenyl)hydrazide Benzoic Acid is an impurity of the anti-inflammatory drug indomnethacin (I641000). Indomethacin inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). A clinically useful NAISD.

4-Chloro-2-(4-chlorobenzoyl)-1-(4-Methoxyphenyl)hydrazide Benzoic Acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Indapamide EP Impurity F Indomethacin EP Impurity F Indometacin Impurity 14 Indomethacin Impurity 6(Indomethacin EP Impurity F) Indometacin EP Impurity F Indomethacin Impurity F Indometacin (Indomethacin) EP Impurity F Indomethacin impurity 5/Indomethacin EP Impurity F/2-(4-Chlorobenzoyl)-1-(4-methoxyphenyl)hydrazide-4-chloro-benzoic acid Indomethacin (Indometacin) EP Impurity F 4-Chloro-N''-(4-chlorobenzoyl)-N-(4-methoxyphenyl)benzohydrazide Benzoic acid, 4-chloro-, 2-(4-chlorobenzoyl)-1-(4-methoxyphenyl)hydrazide (Indometacin Impurity) Benzoic acid, 4-chloro-, 2-(4-chlorobenzoyl)-1-(4-methoxyphenyl)hydrazide 4-Chloro-2-(4-chlorobenzoyl)-1-(4-methoxyphenyl)hydrazide Benzoic Acid 402849-27-8 Amines, Aromatics, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals