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Pranlukast

CAS No.: 103177-37-3

Chemical Name:: Pranlukast

Synonyms: Onon;rs411;Ultair;ono1078;Prenast;Pranlukas;ONO-RS-411;emihydrate;PRANLUKAST;ONO-RS-411-01

CBNumber:: CB3271355

Molecular Formula:: C27H23N5O4

Molecular Weight:: 481.5

MOL File:: 103177-37-3.mol

MSDS File:: SDS

Modify Date:: 2024/6/6 17:55:34

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Pranlukast Properties

Melting point	236-238°C
Density	1.374±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Soluble in DMSO (up to 25 mg/ml)
form	solid
pka	4.96±0.10(Predicted)
color	White
Merck	14,7710
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
CAS DataBase Reference	103177-37-3(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H413

Precautionary statements

P501-P273-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Hazard Codes

F,C

Risk Statements

11-34

Safety Statements

16-26-36/37/39-45

RTECS

CV5647500

HS Code

2934.99.4400

Toxicity

LD50 in male mice (mg/kg): >1000 i.v. (Toda)

NFPA 704

	0
2		0

Pranlukast price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemicals (India)	P2115	Pranlukast	103177-37-3	25MG	₹2600	2022-05-26	Buy
TCI Chemicals (India)	P2115	Pranlukast	103177-37-3	100MG	₹8100	2022-05-26	Buy

Product number	Packaging	Price	Buy
P2115	25MG	₹2600	Buy
P2115	100MG	₹8100	Buy

Pranlukast Chemical Properties,Uses,Production

Description

Pranlukast, a novel chromone derivative, was introduced in Japan for the treatment of bronchial asthma and allergic diseases. Pranlukast is a highly potent, selective and competitive antagonist of peptidoleukotrienes with high affinity for the LTD₄ receptor. In patients with bronchial asthma, pranlukast was reported to induce significant improvement in both immediate and late asthmatic response induced by antigen. Pranlukast is also being evaluated clinically for the treatment of perennial allergic rhinitis, pediatric asthma, and cutaneous pruritus in dialysis patients. The therapeutic potential of pranlukast in managing irritable bowel syndrome has been suggested.

Chemical Properties

Off-white solid

Uses

Labeled Pranlukast, intended for use as an internal standard for the quantification of Pranlukast by GC- or LC-mass spectrometry.

Biological Activity

Selective cysteinyl leukotriene receptor 1 (CysLT 1 ) antagonist (IC 50 values are ~ 4-7 and 3620 nM for CysLT 1 and CysLT 2 respectively). Inhibits contraction of airway smooth muscle, microvascular leakage into airways and eosinophil infiltration. Can decrease symptoms of bronchial asthma.

Pranlukast Preparation Products And Raw materials

Raw materials

4-Phenylbutanol

Preparation Products

Pranlukast Suppliers

Global( 273)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Manus Aktteva	+91 (79) 6512-3395	New Delhi, India	581	34	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Thykn India International	08048372611Ext 128	Mumbai, India	22	58	Inquiry
Bioorganics & Applied Materials Pvt. Ltd.	08048250473Ext 567	Karnataka, India	46	58	Inquiry
RA Chem Pharma Limited	07093802565	Hyderabad, India	2	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Shagun Pharmaceuticals	91-731-2575029	Madhya Pradesh, India	193	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry

Supplier	Advantage
Manus Aktteva	34
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
Thykn India International	58
Bioorganics & Applied Materials Pvt. Ltd.	58
RA Chem Pharma Limited	58
SynZeal Research Pvt Ltd	58
Shagun Pharmaceuticals	58
TCI Chemicals (India) Pvt. Ltd.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58

Pranlukast Spectrum

Pranlukast(103177-37-3)¹HNMR

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PRANLUKAST 4-oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4h-1-benzopyranh benzamide,n-(4-oxo-2-(1h-tetrazol-5-yl)-4h-1-benzopyran-8-yl)-4-(4-phenylbutox emihydrate ONO-RS-411 ONO-RS-411-01 N-[4-keto-2-(2H-tetrazol-5-yl)chromen-7-yl]-4-(4-phenylbutoxy)benzamide N-[4-oxo-2-(2H-1,2,3,4-tetrazol-5-yl)chromen-7-yl]-4-(4-phenylbutoxy)benzamide N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-7-yl]-4-(4-phenylbutoxy)benzamide n-(4-oxo-2-(1h-tetrazol-5-yl)-4h-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzam BenzaMide,N-[4-oxo-2-(2H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)- N-[4-oxo-2-(2H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)-benzamide 4-Oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4H-1-benzopyran4-Oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4H-1-benzopyran Pranlukast-d4 Onon Pranlukast (ONO 1078) ono1078 rs411 N-{4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)benzamide, ONO-1078, ONO-RS-411, Onon, 4-Oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4H-1-benzopyran N-(4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzamide N-[4-oxo-2-(2H-tetrazol-5-yl)-1-benzopyran-8-yl]-4-(4-phenylbutoxy)benzamide Pranlukast > Pranlukast RS Pranlukas EP/GMP/FDA Pranlukast Pranlukast USP/EP/BP Pranlukast (1.0mg/ml in DMSO) Pranlukast (10mM in DMSO) Pranlukast D4Q: What is Pranlukast D4 Q: What is the CAS Number of Pranlukast D4 Q: What is the storage condition of Pranlukast D4 Q: What are the applications of Pranlukast D4 Prenast Ultair 103177-37-3 C27H23N5O4 API Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Antiasthmatic