Sofosbuvir IMpurity C

Sofosbuvir IMpurity C Structure
CAS No.
1337482-15-1
Chemical Name:
Sofosbuvir IMpurity C
Synonyms
Ofosbuvi rimpurity;Sofosbuvir impurity G;sofosbuvir impurity Y008005-G;Sofosbuvir IMpurity C 1337482-15-1;Sofosbuvir impurity G,inhibit,Inhibitor;Sofosbuvir 5'-Desphosphate 3’-O-[(S)-Phosphate];L-Alanine, N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-3'-uridylyl]-, 1-methylethyl ester;((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosph;isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosph;isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)-L-alanite
CBNumber:
CB32716544
Molecular Formula:
C22H29FN3O9P
Molecular Weight:
529.45
MOL File:
1337482-15-1.mol
Modify Date:
2024/7/2 8:55:06

Sofosbuvir IMpurity C Properties

Density 1.41±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility soluble in No data available
pka 9.39±0.10(Predicted)
form Solid
color White to off-white

Sofosbuvir IMpurity C Chemical Properties,Uses,Production

Uses

Sofosbuvir 5''-Desphosphate 3''-O-[(S)-Phosphate] is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

Sofosbuvir IMpurity C Preparation Products And Raw materials

Raw materials

Preparation Products

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Sofosbuvir IMpurity C 1337482-15-1 Ofosbuvi rimpurity isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)-L-alaninate Sofosbuvir impurity G isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosph L-Alanine, N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-3'-uridylyl]-, 1-methylethyl ester Sofosbuvir impurity 18/Sofosbuvir 3'-O-Phosphoramidate/Isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)-L-alaninate sofosbuvir impurity Y008005-G Sofosbuvir 5'-Desphosphate 3’-O-[(S)-Phosphate] isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)-L-alanite (2S)-Isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)amino)propanoate Sofosbuvir impurity G,inhibit,Inhibitor ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosph 1337482-15-1 1496552-51-1