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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Cell Cycle >Rho inhibitor >K-Ras(G12C) inhibitor 9

K-Ras(G12C) inhibitor 9

K-Ras(G12C) inhibitor 9 Structure
CAS No.
1469337-91-4
Chemical Name:
K-Ras(G12C) inhibitor 9
Synonyms
K-RAS inhibitor 9;K-Ras(G12C) inhibitor 9;K-Ras(GI2C) Inhibitor 9;K-Ras(G12C) inhibitor 9 USP/EP/BP;K RAS INHIBITOR-9; KRAS INHIBITOR 9;N-[1-[2-[(4-chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]-ethenesulfonamide;Ethenesulfonamide, N-[1-[2-[(4-chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]-;K-Ras(G-12C) inhibitor 9,KRas(G12C) inhibitor 9,Ras,Inhibitor,K-Ras(G12C) inhibitor 9,inhibit,K Ras(G12C) inhibitor 9
CBNumber:
CB32722367
Molecular Formula:
C16H21ClIN3O4S
Molecular Weight:
513.78
MOL File:
1469337-91-4.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:06
Request For Quotation

K-Ras(G12C) inhibitor 9 Properties

Boiling point 656.3±65.0 °C(Predicted)
Density 1.68±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form crystalline solid
pka 9.68±0.20(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

K-Ras(G12C) inhibitor 9 Chemical Properties,Uses,Production

Description

K-Ras(G12C) inhibitor 9 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 μM for 24 hours in vitro. K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis. Similar K-Ras(G12C) inhibitors significantly reduce GTP affinity relative to GDP, decrease Raf binding, and lower cell viability while increasing apoptosis.

Uses

N-[1-[2-[(4-Chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]ethenesulfonamide is an allosteric inhibitor of tumor-promoting K-Ras(G12c).

K-Ras(G12C) inhibitor 9 Preparation Products And Raw materials

Raw materials

Preparation Products

K-Ras(G12C) inhibitor 9 Suppliers

Global( 62)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32836 60 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30250 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 24200 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8474 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Shanghai Aladdin Biochemical Technology Co.,Ltd. +86-18521732826 China 48465 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
ATK CHEMICAL COMPANY LIMITED 60
Career Henan Chemica Co 58
Dideu Industries Group Limited 58
InvivoChem 58
TargetMol Chemicals Inc. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Aladdin Scientific 58
Shanghai Aladdin Biochemical Technology Co.,Ltd. 58

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K-Ras(G12C) inhibitor 9 N-[1-[2-[(4-chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]-ethenesulfonamide K RAS INHIBITOR-9; KRAS INHIBITOR 9 K-RAS inhibitor 9 Ethenesulfonamide, N-[1-[2-[(4-chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]- K-Ras(G12C) inhibitor 9 USP/EP/BP K-Ras(G-12C) inhibitor 9,KRas(G12C) inhibitor 9,Ras,Inhibitor,K-Ras(G12C) inhibitor 9,inhibit,K Ras(G12C) inhibitor 9 K-Ras(GI2C) Inhibitor 9 1469337-91-4 C16H21ClIN3O4S Inhibitors