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LONAFARNIB

CAS No.: 193275-84-2

Chemical Name:: LONAFARNIB

Synonyms: Sarasar;Sch66336;Sch 66336;EOS-61911;LONAFARNIB;LonafarMib;SCH-066336;Unii-iow153004f;Lonafarnib [usan];Valine Impurity 114

CBNumber:: CB31011743

Molecular Formula:: C27H31Br2ClN4O2

Molecular Weight:: 638.82

MOL File:: 193275-84-2.mol

MSDS File:: SDS

Modify Date:: 2023/12/27 10:21:05

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LONAFARNIB Properties

Melting point	214.5-215.9° (monohydrate); mp 222-223°
alpha	D25 = +49.1° (c = 0.21 in methanol)
Boiling point	710.4±70.0 °C(Predicted)
Density	1.536
storage temp.	-20°C
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	15.76±0.40(Predicted)
form	powder
color	white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P305+P351+P338

LONAFARNIB price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SML1457	Lonafarnib ≥98% (HPLC)	193275-84-2	5MG	₹13531.25	2022-06-14	Buy
Sigma-Aldrich(India)	SML1457	Lonafarnib ≥98% (HPLC)	193275-84-2	25MG	₹54428.1	2022-06-14	Buy

Product number	Packaging	Price	Buy
SML1457	5MG	₹13531.25	Buy
SML1457	25MG	₹54428.1	Buy

LONAFARNIB Chemical Properties,Uses,Production

Uses

Lonafarnib is an orally bioavailable tricyclic inhibitor of farnesyl protein transferase. It inhibits Rheb farnesylation and mTOR signaling and enhances taxane and tamoxifen antitumor activity. Studies show that it induces CCAAT/enhancer-binding protein homologous protein-dependent expression of death receptor 5, leading to induction of apoptosis in human cancer cells

Definition

ChEBI: A 4-{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxoethyl}piperidine-1-carboxamide that has R configuration. It is used as oral farnesyltransferase nhibitor.

General Description

Lonafarnib (SCH66336) is a farnesyl transferase inhibitor (FTI). K- and N-Ras are substrates of farnesyl transferase.

Mechanism of action

Lonafarnib is a protein farnesyltransferase inhibitor (FTI) that reversibly binds to the farnesyltransferase CAAX binding site9, thereby inhibiting progerin farnesylation and subsequent intercalation into the nuclear membrane.

Side effects

vomiting
diarrhea
nausea
stomach pain
constipation
gas
decreased appetite
decreased weight

LONAFARNIB Preparation Products And Raw materials

Raw materials

Preparation Products

LONAFARNIB Suppliers

Global( 149)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Manus Aktteva	+91 (79) 6512-3395	New Delhi, India	581	34	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29898	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	24639	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry

Supplier	Advantage
Manus Aktteva	34
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
career henan chemical co	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58

How is Lonafarnib synthesised?
Lonafarnib was synthesised starting from the bromination of chloroanthranilic acid and using the lonafarnib precursor tricycle....
Dec 27，2023

LONAFARNIB Spectrum

LONAFARNIB(193275-84-2)¹HNMR

193275-84-2(LONAFARNIB)Related Search:

Everolimus Selumetinib MK-2206 2HCl Tipifarnib Ibrutinib

PLX4032 PIPERIDINE, 4-[(2-METHYLPHENYL)METHYL]-, HYDROCHLORIDE 1-Bromo-4-chloro-2-methylbenzene LONAFARNIB 4-(2-METHYL-BENZYL)-PIPERIDINE

Pyridine, 3-bromo-5-ethyl- (9CI) 1-(2-PIPERIDIN-4-YL-ETHYL)-PIPERIDINE 4-(4-CHLOROBENZYL)PIPERIDINE

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LONAFARNIB 4-(2-(4-((R)-3,10-dibroMo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)cyclohexyl)-2-oxoethyl)piperidine-1-carboxaMide Lonafarnib (SCH66336) 1-Piperidinecarboxamide, 4-(2-(4-((11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-B)pyridin-11-yl)-1-piperidinyl)-2-oxoethyl)- 4-(2-(4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo-(5,6)-cyclohepta(1,2-B)-pyridin-11(R)-yl)-1-piperidinyl)-2-oxo-ethyl)-1-piperidinecarboxamide Lonafarnib [usan] Sarasar Sch 66336 Sch66336 Unii-iow153004f 4-[2-[4-[(11R)-3,10-DibroMo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1- 1-PiperidinecarboxaMide, 4-[2-[4-[(11R)-3,10-dibroMo-8-chloro-6 LonafarMib (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide ( )4-(2-(4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo(5,6)cyclohepta (1,2-b)pyridin-11-yl)-1-piperidinyl)-2-oxoethyl)-1-piperidinecarboxami de 4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide SARASAR; SCH 66336; SCH66336; SCH-66336 EOS-61911 SCH-066336 LONAFARNIB USP/EP/BP Lonafarnib Sarasar SCH 66336 Valine Impurity 114 193275-84-2 Inhibitor Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals APIs