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5,5-DIMETHYL-1-PYRROLINE N-OXIDE

CAS No.: 3317-61-1

Chemical Name:: 5,5-DIMETHYL-1-PYRROLINE N-OXIDE

Synonyms: DMPO;2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRROLE 1-OXIDE;5,5-dimethyl-1-pyrroline-1-oxide;3,4-DIHYDRO-2,2-DIMETHYL-2H-PYRROLE 1-OXIDE;Dimethyl N;spintrappingreagent;,5-Dimethyl-1-pyrroline N-oxide;5,5-DIMETHYL-1-PYRROLINE N-OXIDE;5,5-Dimethyl-1-Pyrrolidine-N-oxide;5,5-Dimethyl-1-pyrrolineN-Oxide>

CBNumber:: CB3290637

Molecular Formula:: C6H11NO

Molecular Weight:: 113.16

MOL File:: 3317-61-1.mol

MSDS File:: SDS

Modify Date:: 2023/6/8 17:06:37

Request For Quotation

5,5-DIMETHYL-1-PYRROLINE N-OXIDE Properties

Melting point	25-29 °C (lit.)
Boiling point	75 °C/0.4 mmHg (lit.)
Density	1.015 g/mL at 25 °C (lit.)
refractive index	n20/D 1.496(lit.)
Flash point	204 °F
storage temp.	-20°C
solubility	Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
form	Pale yellow solid or oil.
pka	2.47±0.40(Predicted)
color	Pale yellow
Merck	14,3393
BRN	107603
Stability	Stable, but light sensitive, hygroscopic and heat sensitive. Store in the dark, under an inert gas, and keep cold. Incompatible with strong oxidizing agents, moisture.
InChIKey	VCUVETGKTILCLC-UHFFFAOYSA-N
CAS DataBase Reference	3317-61-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P280-P305+P351+P338-P321

Safety Statements

24/25

WGK Germany

8-10

HazardClass

IRRITANT

HS Code

29339900

NFPA 704

	1
0		0

5,5-DIMETHYL-1-PYRROLINE N-OXIDE price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	92688	5,5-Dimethyl-1-pyrroline N-oxide for ESR-spectroscopy	3317-61-1	100MG	₹12156.48	2022-06-14	Buy
TCI Chemicals (India)	D2362	5,5-Dimethyl-1-pyrroline N-Oxide min. 97.0 %	3317-61-1	1G	₹17000	2022-05-26	Buy
TCI Chemicals (India)	D2362	5,5-Dimethyl-1-pyrroline N-Oxide min. 97.0 %	3317-61-1	5G	₹30800	2022-05-26	Buy

Product number	Packaging	Price	Buy
92688	100MG	₹12156.48	Buy
D2362	1G	₹17000	Buy
D2362	5G	₹30800	Buy

5,5-DIMETHYL-1-PYRROLINE N-OXIDE Chemical Properties,Uses,Production

Description

Free radicals are highly reactive, short-lived species. Spin traps react with radicals, forming stable adducts that can be further studied. DMPO is a commonly-used spin trap that reacts with O-, N-, S-, and C-centered radicals. This allows their characterization when used in association with electron spin resonance and immuno-spin trapping. DMPO is water-soluble, rapidly penetrates lipid bilayers, has low toxicity, and can be used in vitro and in vivo.

Chemical Properties

white to faintly yellow solid

Uses

5,5-Dimethyl-1-pyrroline N-oxide is a reagent generally used either as a free-radical spin-trapping agent, or electrophilic component during the synthesis of pyrrolidine derivatives. It may also be considered as 1,3-dipole in cycloaddition processes.

Preparation

To a three-necked round bottom flask equipped with a condenser, addition funnel, thermometer, and mechanical stirrer and containing 300 ml. 95% ethanol precooled to 2°C is added, all at once, 14.5 g (0.1 mole) 4-methyl-4-nitropentanol, and 13.1 g (1.2 mole) zinc dust. With rapid agitation, the glacial acetic acid (24.0 g, 0.4 mole) is added dropwise over a 1-hr period while maintaining the reaction temperature below 15°C. The mixture is stirred vigorously for 2 hr and then stored in the refrigerator for 2 days, at approximately 1°C. Then the zinc acetate is filtered and rinsed with 100 ml of ethanol. The combined ethanol factions are rotoevapo-rated to give the crude nitrone. The crude nitrone is dissolved in a 200 ml portion of dichloromethane and the latter washed two times with saturated sodium bicarbonate solution. The organic layer is dried over sodium sulfate and the solvent rotoevaporated, to give 10.7 (94% yield) of the crude nitrone. The product was purified by double distillation (b.p. 53°C, 0.1 Torr), to give 6.8 g (60%) of the pure nitrone as a white hygroscopic solid. The H¹ NMR (400 MH CDC1₃, Me₄Si) is 6.80 (t, 2H, methylene bound to quaternary C, J = 7.2Hg), 1.43 (s, 6H, methyl), C¹³NMr (100 MH2, CDC13, Me₄ Si) 5=132.4 (Vinyl), 73.5 (quaternary), 34.1 (Allyl), 25.3 (methylene bound to quaternary C), 24.4 (methyls).
Preparation of 5,5-dimethyl-l-pyrroline-N-oxide

Biological Activity

Water soluble nitric oxide spin trap; allows the measurement of oxygen-centered free radicals in biological systems at room temperature using electron spin resonance (ESR). Has a high reaction rate constant for superoxide and hydroxyl radicals, and distinguishes simultaneously among a variety of important biologically generated free radicals.

Physiological effects

5,5-dimethyl-1-pyrroline N-oxide is used as a spin trap for the study of radicals formed by enzymatic acetaldehyde oxidation. It has a role as a neuroprotective agent and a spin trapping reagent.

5,5-DIMETHYL-1-PYRROLINE N-OXIDE Preparation Products And Raw materials

Raw materials

Preparation Products

4-METHYLPHTHALIMIDE 99

5,5-DIMETHYL-1-PYRROLINE N-OXIDE Suppliers

Global( 217)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
Apex Scientist Chemicals, USA	09582832027	Delhi, India	130	58	Inquiry
Clearsynth Labs	91-22-45045900	Maharashtra, India	3889	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	57511	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	China	18648	58	Inquiry
Accela ChemBio Inc.	+1-858-6993322	United States	19479	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49392	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
TCI Chemicals (India) Pvt. Ltd.	58
Apex Scientist Chemicals, USA	58
Clearsynth Labs	58
Aladdin Scientific	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Accela ChemBio Inc.	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58

5,5-DIMETHYL-1-PYRROLINE N-OXIDE Spectrum

5,5-DIMETHYL-1-PYRROLINE N-OXIDE(3317-61-1)¹HNMR 5,5-DIMETHYL-1-PYRROLINE N-OXIDE(3317-61-1)IR 5,5-DIMETHYL-1-PYRROLINE N-OXIDE(3317-61-1)FT-IR 5,5-DIMETHYL-1-PYRROLINE N-OXIDE(3317-61-1)Raman

3317-61-1(5,5-DIMETHYL-1-PYRROLINE N-OXIDE)Related Search:

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5,5-DIMETHYL-1-PYRROLINE N-OXIDE 5,5-Dimethyl-1-pyrroline N-oxide [spin trapping spintrappingreagent 1-Oxylato-2,2-dimethyl-3,4-dihydro-2H-pyrrole-1-ium 3,4-Dihydro-1-oxylato-2,2-dimethyl-2H-pyrrolium 5,5-Dimethyl-1-Pyrrolidine-N-oxide 5,5-DIMETHYL-1-PYRROLINE N-OXIDE, [SPIN TRAPPING REAGENT] 5,5-DIMETHYL-1-PYRROLINE N-OXIDE [SPIN TRAPPING REAGENT] 97+% 5,5-DIMETHYL-1-PYRROLINE N-OXIDE 99% 2,2-dimethyl-1-oxidanidyl-3,4-dihydropyrrol-1-ium 2,2-dimethyl-1-oxido-1-pyrrolin-1-ium 2,2-dimethyl-1-oxido-3,4-dihydropyrrol-1-ium 5,5-Dimethyl-1-pyrroline N-oxide ,97% 5,5-Dimethyl-1-pyrroline N-oxide,DMPO 2,2-diMethyl-2,3-dihydro-1H-pyrrole 1-oxide ,5-Dimethyl-1-pyrroline N-oxide Dimethyl N 5,5-Dimethyl-1-pyrrolineN-Oxide> 2,2-Dimethyl-3,4-Dihydro-2H-Pyrrole 1-Ox 3,4-Dihydro-2,2-dimethyl-2H-pyrrole N-oxide 95% DMPO 2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRROLE 1-OXIDE 5,5-dimethyl-1-pyrroline-1-oxide 3,4-DIHYDRO-2,2-DIMETHYL-2H-PYRROLE 1-OXIDE 5,5-Dimethyl-1-pyrroline N-Oxide, ≥ 97.0% 3317-61-1 Enzymes, Inhibitors, and Substrates Pyrrolines Nitric Oxide Metabolism Nitric Oxide Scavengers ESR Spectrometry Spin Trapping Reagents Building Blocks Biochemicals and Reagents Application Index BioChemical Cell Signaling Enzymes Heterocyclic Building Blocks pharmacetical Analytical Chemistry ESR Spectrometry Spin Trapping Reagents