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ML 18

ML 18 Structure
CAS No.
1422269-30-4
Chemical Name:
ML 18
Synonyms
ML 18;ML18, >98%;BRS-3 antagonist;ML18;ML-18;ML 18;BRS-3 ANTAGONIST;1422269-30-4;Bombesin Receptor,ML-18,ML 18,inhibit,Inhibitor,ML18;(S)-3-(1H-Indol-3-yl)-N-((1-(4-methoxyphenyl)cyclohexyl)methyl)-2-(3-(4-nitrophenyl)ureido)propanamide;(2S)-3-(1H-INDOL-3-YL)-N-{[1-(4-METHOXYPHENYL)CYCLOHEXYL]METHYL}-2-{[(4-NITROPHENYL)CARBAMOYL]AMINO}PROPANAMIDE
CBNumber:
CB33170389
Molecular Formula:
C32H35N5O5
Molecular Weight:
569.66
MOL File:
1422269-30-4.mol
Modify Date:
2024/7/2 8:55:06
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ML 18 Properties

Boiling point 821.8±65.0 °C(Predicted)
Density 1.291±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble
form A solid
pka 11.99±0.46(Predicted)
color White to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

ML 18 Chemical Properties,Uses,Production

Description

ML-18 is a non-peptide bombesin receptor subtype 3 (BB3) antagonist that inhibits [125I]BA1 binding to NCI-H1299 lung cancer cells transfected with human BB3 receptors (IC50 = 4.8 μM). It is selective for BB3 over the gastrin releasing peptide receptor (GRPR) and the neuromedin B receptor (NMBR) with IC50 values of 16 and >100 μM, respectively, in a radioligand binding assay. ML-18 (16 μM) reversibly inhibits BA1-induced increases in cytosolic calcium in NCI-H1299 cells. It also inhibits BA1-induced phosphorylation of ERK and EGFR and reduces proliferation of NCI-H1299 cells.

Uses

ML-18 is a non-peptide bombesin receptor subtype-3 antagonist. It also inhibits lung cancer growth.

ML 18 Preparation Products And Raw materials

Raw materials

Preparation Products

ML 18 Suppliers

Global( 46)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32836 60 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8474 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Shanghai Aladdin Biochemical Technology Co.,Ltd. +86-18521732826 China 48465 58 Inquiry
InvivoChem 13549236410 China 6755 58 Inquiry
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 China 5585 58 Inquiry
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. 025-66061636 18013972705 China 8263 58 Inquiry
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
InvivoChem 58
TargetMol Chemicals Inc. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Aladdin Scientific 58
Shanghai Aladdin Biochemical Technology Co.,Ltd. 58
InvivoChem 58
Nanjing Tengyi Biotechnology Co., Ltd 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. 58

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ML 18 BRS-3 antagonist ML18;ML-18;ML 18;BRS-3 ANTAGONIST;1422269-30-4 ML18, >98% (2S)-3-(1H-INDOL-3-YL)-N-{[1-(4-METHOXYPHENYL)CYCLOHEXYL]METHYL}-2-{[(4-NITROPHENYL)CARBAMOYL]AMINO}PROPANAMIDE (S)-3-(1H-Indol-3-yl)-N-((1-(4-methoxyphenyl)cyclohexyl)methyl)-2-(3-(4-nitrophenyl)ureido)propanamide Bombesin Receptor,ML-18,ML 18,inhibit,Inhibitor,ML18 1422269-30-4