ML 18
![ML 18 Structure](CAS/20211123/GIF/1422269-30-4.gif)
- CAS No.
- 1422269-30-4
- Chemical Name:
- ML 18
- Synonyms
- ML 18;ML18, >98%;BRS-3 antagonist;ML18;ML-18;ML 18;BRS-3 ANTAGONIST;1422269-30-4;Bombesin Receptor,ML-18,ML 18,inhibit,Inhibitor,ML18;(S)-3-(1H-Indol-3-yl)-N-((1-(4-methoxyphenyl)cyclohexyl)methyl)-2-(3-(4-nitrophenyl)ureido)propanamide;(2S)-3-(1H-INDOL-3-YL)-N-{[1-(4-METHOXYPHENYL)CYCLOHEXYL]METHYL}-2-{[(4-NITROPHENYL)CARBAMOYL]AMINO}PROPANAMIDE
- CBNumber:
- CB33170389
- Molecular Formula:
- C32H35N5O5
- Molecular Weight:
- 569.66
- MOL File:
- 1422269-30-4.mol
- Modify Date:
- 2024/7/2 8:55:06
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P305+P351+P338 | |||||||||
NFPA 704 |
|
ML 18 Chemical Properties,Uses,Production
Description
ML-18 is a non-peptide bombesin receptor subtype 3 (BB3) antagonist that inhibits [125I]BA1 binding to NCI-H1299 lung cancer cells transfected with human BB3 receptors (IC50 = 4.8 μM). It is selective for BB3 over the gastrin releasing peptide receptor (GRPR) and the neuromedin B receptor (NMBR) with IC50 values of 16 and >100 μM, respectively, in a radioligand binding assay. ML-18 (16 μM) reversibly inhibits BA1-induced increases in cytosolic calcium in NCI-H1299 cells. It also inhibits BA1-induced phosphorylation of ERK and EGFR and reduces proliferation of NCI-H1299 cells.
Uses
ML-18 is a non-peptide bombesin receptor subtype-3 antagonist. It also inhibits lung cancer growth.
ML 18 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 46)Suppliers
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ML 18
BRS-3 antagonist
ML18;ML-18;ML 18;BRS-3 ANTAGONIST;1422269-30-4
ML18, >98%
(2S)-3-(1H-INDOL-3-YL)-N-{[1-(4-METHOXYPHENYL)CYCLOHEXYL]METHYL}-2-{[(4-NITROPHENYL)CARBAMOYL]AMINO}PROPANAMIDE
(S)-3-(1H-Indol-3-yl)-N-((1-(4-methoxyphenyl)cyclohexyl)methyl)-2-(3-(4-nitrophenyl)ureido)propanamide
Bombesin Receptor,ML-18,ML 18,inhibit,Inhibitor,ML18
1422269-30-4