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4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE

4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE Structure
CAS No.
94-19-9
Chemical Name:
4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE
Synonyms
setd;etazol;etazole;globucid;ethazole;globucin;globuzid;sethadil;aethazol;berlophen
CBNumber:
CB3325377
Molecular Formula:
C10H12N4O2S2
Molecular Weight:
284.36
MOL File:
94-19-9.mol
Modify Date:
2023/5/4 17:34:43
Request For Quotation

4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE Properties

Melting point 185.5-186.0°
Density 1.3410 (rough estimate)
refractive index 1.6440 (estimate)
pka pKa 5.36(H2O t = 37) (Uncertain)
Water Solubility 215mg/L(20 ºC)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319-H302-H335-H315
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P
Hazard Codes  Xi
HazardClass  IRRITANT
Toxicity LD50 intraperitoneal in mouse: 1459mg/kg

4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE Chemical Properties,Uses,Production

Originator

Sul-Spansion,SKF,US,1956

Manufacturing Process

0.163 mol of 2-amino-5-ethyl-1,3,4-thiadiazole was covered with 43 parts of anhydrous pyridine. To the mixture was added 50 parts (0.214 mol) of pacetylaminobenzenesulfonyl chloride with vigorous shaking at 50°C to 60°C. The reaction mixture was then heated to 125°C. When the mixture had cooled somewhat it was placed in a Claisen flask and 27.6 parts (0.69 mol) of sodium hydroxide dissolved in 110 parts of water was added through a dropping funnel while distilling off a mixture of pyridine and water. The distillation was stopped when the temperature reached 100°C and the residual liquor in the flask heated at 95°C for 30 minutes.The reaction mixture was then poured into 1,650 parts of hot water, the pH adjusted to 8 to 9, decolorizing charcoal was added and the whole was heated on the steam for 15 minutes. The charcoal was filtered off and the hot filtrate neutralized and cooled. The 2-(sulfanilamido)-5-ethyl-1,3,4-thiadiazole was purified by repeated crystallization from boiling water.

Therapeutic Function

Antibacterial

4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE Preparation Products And Raw materials

Raw materials

Bismuththiol N-Acetylsulfanilyl chloride

Preparation Products

4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE Suppliers

Global( 28)Suppliers
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Dy - Mach Pharma +91-2265018321 +91-2226833227 Maharashtra, India 18 58 Inquiry
Baoji Guokang Healthchem co.,ltd +8615604608665 15604608665 CHINA 9414 58 Inquiry
DAYANG CHEM (HANGZHOU) CO.,LTD +8617705817739 China 53881 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131957 58 Inquiry
Biosynth Biological Technology (Suzhou) Co Ltd 51288865780 China 233051 58 Inquiry
TCI (Shanghai) Chemical Trading Co., Ltd. 021-021-61109150 China 31121 58 Inquiry
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 China 11973 58 Inquiry
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Absin Bioscience Inc. 021-38015121-8802 CHINA 6208 58 Inquiry
Supplier Advantage
Dy - Mach Pharma 58
Baoji Guokang Healthchem co.,ltd 58
DAYANG CHEM (HANGZHOU) CO.,LTD 58
Amadis Chemical Company Limited 58
Biosynth Biological Technology (Suzhou) Co Ltd 58
TCI (Shanghai) Chemical Trading Co., Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
58
58
Absin Bioscience Inc. 58

94-19-9(4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE)Related Search:

Sulfadimethoxine sodium salt 4-{[(4-chloroanilino)carbonyl]amino}-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide 4-{[3-(1,3-benzodioxol-5-yl)-3-oxo-1-propenyl]amino}-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide 4-{[(cinnamoylamino)carbothioyl]amino}-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide 4-{[3-(4-ethoxyphenyl)-3-oxo-1-propenyl]amino}-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide
4-{[(E)-(4-chlorophenyl)methylidene]amino}-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide 4-{[(E)-1,3-benzodioxol-5-ylmethylidene]amino}-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide 4-{[2-(5-chloro-1,3-benzoxazol-2-yl)-3-oxo-1-propenyl]amino}-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide 4-{[2-(1,3-benzoxazol-2-yl)-3-oxo-1-propenyl]amino}-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide 3-[4-(5-ETHYL-[1,3,4]THIADIAZOL-2-YLSULFAMOYL)-PHENYLCARBAMOYL]-ACRYLIC ACID
SULFAETHIDOLE SODIUM Glyprothiazol glybuthiazol 4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE
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ethazole(pharmaceutical) globucid sulfaethidol sulfaethidole sulfaethylthiadiazole sulfa-perlongit sul-spansion sul-spantab sulphaethidole Sulphanyl acid N-(5-ethyl-1,3,4-thiadiazol-2yl) amide 4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE ethazole globucin globuzid n-(5-ethyl-1,3,4-thiadiazol-2-yl)-sulfanilamid n-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfanilamide setd sethadil sulfaethidiole TIMTEC-BB SBB001155 2-sulfanilamidoaethylthiodiazol 4-amino-n-(5-ethyl-1,3,4-thiadiazol-2-yl)-benzenesulfonamid aethazol berlophen etazol etazole 4-amino-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzene-1-sulfonamide Benzenesulfonamide, 4-amino-N-(5-ethyl-1,3,4-thiadiazol-2-yl)- 94-19-9 C10H12N4O2S2