4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE
- CAS No.
- 94-19-9
- Chemical Name:
- 4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE
- Synonyms
- setd;etazol;etazole;globucid;ethazole;globucin;globuzid;sethadil;aethazol;berlophen
- CBNumber:
- CB3325377
- Molecular Formula:
- C10H12N4O2S2
- Molecular Weight:
- 284.36
- MOL File:
- 94-19-9.mol
- Modify Date:
- 2023/5/4 17:34:43
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H319-H302-H335-H315 |
Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P |
Hazard Codes | Xi |
HazardClass | IRRITANT |
Toxicity | LD50 intraperitoneal in mouse: 1459mg/kg |
4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE Chemical Properties,Uses,Production
Originator
Sul-Spansion,SKF,US,1956
Manufacturing Process
0.163 mol of 2-amino-5-ethyl-1,3,4-thiadiazole was covered with 43 parts of anhydrous pyridine. To the mixture was added 50 parts (0.214 mol) of pacetylaminobenzenesulfonyl chloride with vigorous shaking at 50°C to 60°C. The reaction mixture was then heated to 125°C. When the mixture had cooled somewhat it was placed in a Claisen flask and 27.6 parts (0.69 mol) of sodium hydroxide dissolved in 110 parts of water was added through a dropping funnel while distilling off a mixture of pyridine and water. The distillation was stopped when the temperature reached 100°C and the residual liquor in the flask heated at 95°C for 30 minutes.The reaction mixture was then poured into 1,650 parts of hot water, the pH adjusted to 8 to 9, decolorizing charcoal was added and the whole was heated on the steam for 15 minutes. The charcoal was filtered off and the hot filtrate neutralized and cooled. The 2-(sulfanilamido)-5-ethyl-1,3,4-thiadiazole was purified by repeated crystallization from boiling water.
Therapeutic Function
Antibacterial
4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE Preparation Products And Raw materials
4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Dy - Mach Pharma | +91-2265018321 +91-2226833227 | Maharashtra, India | 18 | 58 | Inquiry |
Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | CHINA | 9427 | 58 | Inquiry |
Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
TCI (Shanghai) Chemical Trading Co., Ltd. | 021-021-61109150 | China | 31163 | 58 | Inquiry |
Alta Scientific Co., Ltd. | 022-6537-8550 15522853686 | China | 4515 | 55 | Inquiry |
Matrix Scientific | 803 788-9494 All other calls | United States | 6655 | 80 | Inquiry |
ChemCollect GmbH | +49 (0) 202 4690049 | Germany | 6214 | 54 | Inquiry |
Bio-Farma | +44 1204 524 929 | United Kingdom | 4236 | 55 | Inquiry |
TimTec Corporation | 302 292 8500 | United States | 6896 | 68 | Inquiry |
AsInEx Ltd. | +7 495 780 3410 | Russia | 6615 | 66 | Inquiry |
Supplier | Advantage |
---|---|
Dy - Mach Pharma | 58 |
Baoji Guokang Healthchem co.,ltd | 58 |
Amadis Chemical Company Limited | 58 |
TCI (Shanghai) Chemical Trading Co., Ltd. | 58 |
Alta Scientific Co., Ltd. | 55 |
Matrix Scientific | 80 |
ChemCollect GmbH | 54 |
Bio-Farma | 55 |
TimTec Corporation | 68 |
AsInEx Ltd. | 66 |
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