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LAT-NET

LAT-NET Structure
CAS No.
607351-44-0
Chemical Name:
LAT-NET
Synonyms
LAT-NET;LATANOPROST ETHYL AMIDE;Bimatoprost Impurity 20;13,14-Dihydro Bimatoprost;N-ETHYL-9ALPHA, 11ALPHA, 15R-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR PROST 5Z-EN-1-AMIDE;(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-N-ethylhept-5-enamide;5-Heptenamide, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-N-ethyl-, (5Z)-
CBNumber:
CB3344563
Molecular Formula:
C25H39NO4
Molecular Weight:
417.58
MOL File:
Mol file
Modify Date:
2023/6/8 9:03:09
Request For Quotation

LAT-NET Properties

Boiling point 640.9±55.0 °C(Predicted)
Density 1.095±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMSO: 50 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 200 μg/ml
pka 14.84±0.70(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H319-H336
Precautionary statements  P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501
NFPA 704
3
2 0

LAT-NET Chemical Properties,Uses,Production

Description

Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity. Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides.

Uses

13,14-Dihydro Bimatoprost can be used as reactant/reagent for preparation of nitrooxy prostamides for treatment of glaucoma. Analog or impurity of the drug Bimatoprost (B386800).

LAT-NET Preparation Products And Raw materials

Raw materials

Preparation Products

LAT-NET Suppliers

Global( 14)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Hubei Aiputi Bioengineering Co., Ltd. 17762444226 China 2402 58 Inquiry
TargetMol Chemicals Inc. 4008200310 China 23962 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 China 8739 58 Inquiry
Shanghai Zerui Biotechnology Co., Ltd. 021-54580889 18321124657 China 10614 58 Inquiry
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 China 5585 58 Inquiry
Shenzhen Roark Pharma-Tec Co., Ltd. 13128912434 China 2579 58 Inquiry
Toronto Research Chemicals +1 (416) 665-9696 Canada 6088 71 Inquiry
Shanghai Hao Zhun Biological Technology Co., Ltd. 15800340161 CHINA 6846 58 Inquiry
Supplier Advantage
SynZeal Research Pvt Ltd 58
Hubei Aiputi Bioengineering Co., Ltd. 58
TargetMol Chemicals Inc. 58
Cayman Chemical Company 81
Shanghai Yifei Biotechnology Co. , Ltd. 58
Shanghai Zerui Biotechnology Co., Ltd. 58
Nanjing Tengyi Biotechnology Co., Ltd 58
Shenzhen Roark Pharma-Tec Co., Ltd. 58
Toronto Research Chemicals 71
Shanghai Hao Zhun Biological Technology Co., Ltd. 58

607351-44-0(LAT-NET)Related Search:

(Z)-7-[(1R,2R,3R,5S)-3,5-DIHYDROXY-2-((E)-(S)-3-HYDROXY-5-PHENYL-PENT-1-ENYL)-CYCLOPENTYL]-HEPT-5-ENOIC ACID METHYL ESTER (-)-Corey Lactone Diol (5-(ethylamino)-5-oxopentyl)triphenylphosphonium bromide 17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA Dimethyl (2-oxo-4-phenylbutyl)phosphonate
17- Phenyl Trinor Prostaglandin F2α Methyl Amide CHEMPACIFIC 59929 HYDRIDE-L 15(R)-17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA Bimatoprost Impurity 9
Bimatoprost Impurity 17 Bimatoprost Impurity 15 Bimatoprost Impurity 22 Bimatoprost Impurity 13 Bimatoprost Impurity 2 (Mixture of Diastereomers)
Bimatoprost Impurity 14 Bimatoprost Impurity 21 Bimatoprost Impurity 18
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LATANOPROST ETHYL AMIDE LAT-NET N-ETHYL-9ALPHA, 11ALPHA, 15R-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR PROST 5Z-EN-1-AMIDE Bimatoprost Impurity 20 (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-N-ethylhept-5-enamide 13,14-Dihydro Bimatoprost 5-Heptenamide, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-N-ethyl-, (5Z)- 607351-44-0 C25H39NO4