Cucurbitacin E
- CAS No.
- 18444-66-1
- Chemical Name:
- Cucurbitacin E
- Synonyms
- 25-acetate;A-ELATERIN;Cucurbit E;α-Elaterine;Cucurbitine E;CUCURBITACIN E;ALPHA-ELATERIN;cucurbitacine-e;alpha-elaterine;CUCURBITACIN E(SH)
- CBNumber:
- CB3372306
- Molecular Formula:
- C32H44O8
- Molecular Weight:
- 556.69
- MOL File:
- 18444-66-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:02:14
| Melting point | 228-234°C |
|---|---|
| alpha | D -59° (c = 0.7 in chloroform) |
| Boiling point | 545.56°C (rough estimate) |
| Density | 1.1059 (rough estimate) |
| refractive index | 1.4900 (estimate) |
| storage temp. | -20°C |
| solubility | DMSO: soluble15mg/mL, clear |
| form | powder |
| pka | 8.51±0.70(Predicted) |
| color | white to beige |
| optical activity | [α]/D -60 to -75°, c = 0.7 (CDCl3) |
| InChIKey | NDYMQXYDSVBNLL-MUYMLXPFSA-N |
| LogP | 3.150 (est) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 25-22 | |||||||||
| Safety Statements | 1-22-45-24/25 | |||||||||
| RIDADR | 3172 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RC6305500 | |||||||||
| HS Code | 29153900 | |||||||||
| Toxicity | LD50 orally in mice: 340 mg/kg (Albert) | |||||||||
| NFPA 704 |
|
Cucurbitacin E price More Price(2)
Cucurbitacin E Chemical Properties,Uses,Production
Description
Cucurbitacin E is a plant-derived triterpene that has diverse biological activities. At a concentration of 10 pM, it reduces MPP+-induced death of neuronal PC12 cells through inhibition of autophagy in vitro. Cucurbitacin E inhibits growth of T24 bladder, MDA-MB-468 and MCF-7 breast, PC3 prostate, and colorectal cancer cell lines (IC50s = 50-1,000 nM) through induction of G2/M arrest and apoptosis. It increases bilirubin binding to human serum albumin (HSA) in human plasma in a dose-dependent manner. Cucurbitacin E also inhibits depolymerization of actin filaments isolated from rabbit skeletal muscle actin and in HeLa cells.
Chemical Properties
white to beige powder
Uses
Cucurbitacin E is a biochemical compound from the family of Cucurbitacins. Cucurbitacin E is a highly oxidated steroid consisting of a tetracyclic triterpene. Cucurbitacin E is known to possess broad spectrum of potential anti-inflammatory, antitumor andantioxidant effects.
Definition
ChEBI: A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 1, 5 and 23.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG.
Cucurbitacin E Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | China | 952 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | China | 3777 | 58 | Inquiry |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | China | 3000 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | China | 11506 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24639 | 58 | Inquiry |
18444-66-1(Cucurbitacin E)Related Search:
1of4
chevron_right