CUCURBITACIN I
- CAS No.
- 2222-07-3
- Chemical Name:
- CUCURBITACIN I
- Synonyms
- JSI-124;Ibamarin;ELATERIN B;NSC 521777;ELATERICIN B;CUCURBITACIN I;5-tetrahydroxy-;cucurbitacine(i);CUCURBITACIN I(SH);CUCURBITACIN I hplc
- CBNumber:
- CB6480840
- Molecular Formula:
- C30H42O7
- Molecular Weight:
- 514.65
- MOL File:
- 2222-07-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 148-150°C |
|---|---|
| Boiling point | 698.3±55.0 °C(Predicted) |
| Density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | ≥22.45 mg/mL in DMSO; insoluble in EtOH; ≥51.2 mg/mL in H2O with ultrasonic |
| pka | 8.51±0.70(Predicted) |
| form | solid |
| color | white to off-white |
| LogP | 2.330 (est) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P330+P331+P310 | |||||||||
| Hazard Codes | Xi,T+ | |||||||||
| Risk Statements | 25-28 | |||||||||
| Safety Statements | 1-22-45-36/37-28 | |||||||||
| RIDADR | UN 2811 6.1/PG 1 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RC6200000 | |||||||||
| Toxicity | LD50 oral in mouse: 5mg/kg | |||||||||
| NFPA 704 |
|
CUCURBITACIN I Chemical Properties,Uses,Production
Definition
ChEBI: A cucurbitacin that is 9,10,14-trimethyl-4,9-cyclo-9,10-secocholesta-2,5,23-triene substituted by hydroxy groups at positions 2, 16, 20 and 25 and oxo groups at positions 1, 11 and 22.
Biological Activity
Selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.
Biochem/physiol Actions
Cucurbitacin I (JSI-124) is a novel selective inhibitor of the janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway with anti-proliferative and anti-tumor properties.
CUCURBITACIN I Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 114)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29901 | 58 | Inquiry |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | China | 3424 | 58 | Inquiry |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | China | 3000 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| ABCR GmbH & CO. KG | 49 721 95061 0 | Germany | 6846 | 75 | Inquiry |
| United States Biological | 800.520.3011 or 781.639.5092 | United States | 6256 | 80 | Inquiry |
| amyjetsci | 027-59626688 18771149750 | China | 3004 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| CLEARSYNTH LABS LTD. | 58 |
| career henan chemical co | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | 58 |
| Chongqing Chemdad Co., Ltd | 58 |
| LEAPCHEM CO., LTD. | 58 |
| Aladdin Scientific | 58 |
| ABCR GmbH & CO. KG | 75 |
| United States Biological | 80 |
| amyjetsci | 58 |
2222-07-3(CUCURBITACIN I)Related Search:
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ELATERICIN B
ELATERIN B
CUCURBITACIN I WITH HPLC
Cucurbitacin I hydrate
Elatericin B, JSI-124, NSC 521777, 2,16α,20,25-Tetrahydroxy-9-methyl-19-Nor-9β,10α-lanosta-1,5,23-triene-3,11,22-trione
(9β,10α,23E)-2,16α,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione
Ibamarin
2,16a,20,25-Tetrahydroxy-9b-methyl-10a-19-norlanosta-1,5,23(E)-triene-3,11,22-trione
2,16α,20,25-tetrahydroxy-9β-methyl-10α-19-norlanosta-1,5,23(E)-triene-3,11,22-trione
19-Norlanosta-1,5,23-triene-3,11,22-trione, 2,16,20,25-tetrahydroxy-9-methyl-, (9b,10a,16a,23E)-
CUCURBITACIN I(SH)
CUCURBITACIN I hplc
(9β,10α,16α,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione
2,16α,20,25-tetrahydroxy-9-methyl-19-Nor-9β,10α-lanosta-1,5,23-triene-3,11,22-trione
NSC 521777
Cucurbitacin I (JSI-124)
calebassine/cucurbitacin
CUCURBITACIN I
1,2-dehydroelatericina
19-nor-9-beta,10-alpha-lanosta-1,5,23-triene-3,11,22-trione,9-methyl-2,16,20,2
JSI-124
2,16alpha,20,25-tetrahydroxy-9beta-methyl-10alpha-19-norlanosta-1,5,23(E)-triene-3,11,22-trione
5-tetrahydroxy-
cucurbitacine(i)
Cucurbitacin I (Elatericin B
19-Norlanosta-1,5,23-triene-3,11,22-trione, 2,16,20,25-tetrahydroxy-9-methyl-, (9β,10α,16α,23E)-
2222-07-3
2222-7-3
Inhibitor
Herb extract
API
Tri-Terpenoids