NEMONAPRIDE

CAS No.: 75272-39-8

Chemical Name:: NEMONAPRIDE

Synonyms: C12915;Emilace;ym-09151;emonapride;YM 09151-2;NEMONAPRIDE;nobenzamide;inobenzamide;(2R,3R)-nemonapride;cis-(+-)-rrolidinyl)

CBNumber:: CB3492220

Molecular Formula:: C21H26ClN3O2

Molecular Weight:: 387.9

MOL File:: 75272-39-8.mol

Modify Date:: 2023/6/30 15:45:59

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NEMONAPRIDE Properties

Melting point	152-153°C
storage temp.	Store at RT
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
color	White to Off-White
CAS DataBase Reference	75272-39-8

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P330-P501

NFPA 704

	0
2		0

NEMONAPRIDE Chemical Properties,Uses,Production

Description

Nemonapride is a potent dopamine D₂receptor antagonist antipsychotic reported to have superior efficacy against hallucinations and delusions and also to be effective in the treatment of negative symptoms. The compound is a benzamide diastereomer and, although more potent than haloperidol, side effects are reported to be few primarily akinesia and some muscle rigidity with extrapyramidal symptoms being rare.

Chemical Properties

Colourless Crystalline Solid

Uses

Nemonapride is a selective dopamine D2 receptor antagonist. Nemonapride is used as an antipsychotic.

Biological Activity

Highly potent dopamine D 2 -like receptor antagonist; selective over D 1 -like receptors (K i values are 0.1 and 740 nM for D 2 -like and D 1 -like receptors respectively). Also potent 5-HT 1A receptor agonist (IC 50 = 34 nM) and has affinity for sigma receptors.

NEMONAPRIDE Preparation Products And Raw materials

Raw materials

Ethyl chloroformate Hydroxylamine hydrochloride Nemonapride

Preparation Products

NEMONAPRIDE Suppliers

Global( 47)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	China	49739	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	52927	58	Inquiry
Nantong Hanfang Biotechnology Co. , Ltd.	18616537568	China	30968	58	Inquiry
TargetMol Chemicals Inc.	4008200310	China	23962	58	Inquiry
Cayman Chemical Company	(800) 364-9897	United States	6618	81	Inquiry
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	China	8739	58	Inquiry
BOC Sciences		USA	0	65	Inquiry
BIOTREND Chemicals AG	+41 44 805 76 76	Germany	1250	62	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
TargetMol Chemicals Inc.	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
Aladdin Scientific	58
Nantong Hanfang Biotechnology Co. , Ltd.	58
TargetMol Chemicals Inc.	58
Cayman Chemical Company	81
Shanghai Yifei Biotechnology Co. , Ltd.	58
BOC Sciences	65
BIOTREND Chemicals AG	62

75272-39-8(NEMONAPRIDE)Related Search:

(S)-TERT-LEUCINOL 1-BENZYL-3-ACETAMIDOPYRROLIDINE (R)-(-)-1-Benzyl-3-aminopyrrolidine (3R)-(-)-1-BENZYL-3-(ETHYLAMINO)PYRROLIDINE METOCLOPRAMIDE HCL

(R)-(+)-BENZYL-3-ACETYLAMINOPYRROLIDINE& NEMONAPRIDE (3R)-(-)-1-BENZYL-3-(METHYLAMINO)PYRROLIDINE (S)-(+)-1-Benzyl-3-aminopyrrolidine (3R)-(+)-3-(METHYLAMINO)PYRROLIDINE

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1-Benzyl-3-aminopyrrolidine N,N'-DIBENZYL-3-AMINOPYRROLIDINE Declopramide

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CIS-5-CHLORO-2-METHOXY-4-(METHYLAMINO)-N-[2-METHYL-1-(PHENYLMETHYL)-3-PYRROLIDINYL]BENZAMIDE REL-5-CHLORO-2-METHOXY-4-(METHYLAMINO)-N-[(2R,3R)-2-METHYL-2-(PHENNYLMETHYL)-3-PYRROLIDINYL]BENZAMIDE NEMONAPRIDE (+-)-cis-n-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylami benzamide,5-chloro-2-methoxy-4-(methylamino)-n-(2-methyl-1-(phenylmethyl)-3-py cis-(+-)-rrolidinyl) emonapride inobenzamide n-(2rs,3rs)-(1-benzyl-2-methyl-3-pyrrolidinyl)-5-chloro-2-methoxy-4-methylam nobenzamide ym-09151 Benzamide, 5-chloro-2-methoxy-4-(methylamino)-N-[(2R,3R)-2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]-, rel- (9CI) Benzamide, 5-chloro-2-methoxy-4-(methylamino)-N-[2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]-, cis- Emilace YM 09151-2 N-[(2R,3R)-1-Benzyl-2-methylpyrrolidine-3-yl]-2-methoxy-4-(methylamino)-5-chlorobenzamide C12915 cis-5-Chloro-2-Methoxy-4-(MethylaMino)-N-[2-Methyl-1- (phennylMethyl)-3-pyrrolidinyl]benzaMide rel-5-Chloro-2-Methoxy-4-(MethylaMino)-N-[(2R,3R)-2-Methyl-1-(phennylMethyl)-3-pyrrolidinyl]benzaMide cis-5-Chloro-2-methoxy-4-(methylamino)-N-[2-methyl-2-(phenylmethyl)-3-pyrrolidinyl]benzamide (2R,3R)-nemonapride N-(Cis-1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide 75272-39-8 C21H26Cl23O2 Aromatics Heterocycles Heterocyclic Compounds Intermediates & Fine Chemicals Neurochemicals Pharmaceuticals Dopamine receptor