Leupeptin
- CAS No.
- 103476-89-7
- Chemical Name:
- Leupeptin
- Synonyms
- LEUPEPTIN HEMISULFATE;LEUPEPTIN HEMISULFATE SALT;CS-2263;LEUPEPTIN;AC-LLR-CHO;LEUPEPTIN SULFATE;AC-LEU-LEU-ARG-CHO;LEUPEPTIN 1/2 H2SO4;Leupeptin USP/EP/BP;AC-LEU-LEU-ARGININAL
- CBNumber:
- CB3666742
- Molecular Formula:
- C20H40N6O8S
- Molecular Weight:
- 524.63
- MOL File:
- 103476-89-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/18 8:51:57
| alpha | -76 º (c=1, water) |
|---|---|
| storage temp. | -20°C |
| solubility | H2O: 10 mM Solutions are stable for a week at 4 °C. Stock solutions are stable up to 6 months at −20°C. |
| form | Powder |
| color | White to Off-white |
| Water Solubility | soluble |
| Stability | Stable for 1 year from date of purchase as supplied Solutions in distilled water, ethanol or methanol may be stored at -20°C for up to 3 months. |
| InChIKey | CIPMKIHUGVGQTG-VFFZMTJFSA-N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332 | |||||||||
| Precautionary statements | P261-P264-P280-P302+P352+P312-P304+P340+P312-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-63-36/37/38 | |||||||||
| Safety Statements | 22-24/25-36/37-36-36/37/39-26-7/8 | |||||||||
| RIDADR | 3077 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-23 | |||||||||
| HS Code | 29252900 | |||||||||
| NFPA 704 |
|
Leupeptin price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | L8511 | Leupeptin synthetic, ≥85% (HPLC) | 103476-89-7 | 5MG | ₹14473.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | L8511 | Leupeptin synthetic, ≥85% (HPLC) | 103476-89-7 | 10MG | ₹20286.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | L8511 | Leupeptin synthetic, ≥85% (HPLC) | 103476-89-7 | 25MG | ₹48171.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | L8511 | Leupeptin synthetic, ≥85% (HPLC) | 103476-89-7 | 50MG | ₹74519.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | L8511 | Leupeptin synthetic, ≥85% (HPLC) | 103476-89-7 | 100MG | ₹118533.75 | 2022-06-14 | Buy |
Leupeptin Chemical Properties,Uses,Production
Chemical Properties
White to off-white lyophilized powder
Uses
Reversible protease inhibitor, which inhibits cathepsin B, calpain and trypsinPharmaceutical composition containing leupeptin hemisulfate is used as an anti-malarial agent. It is employed in the treatment of noise-induced hearing loss. It also protects the heart from myocardial stunning. Further, it is used to inhibit serine, cysteine proteases, plasmin, trypsin, papain, kallikrein and cathepsin B.
Definition
ChEBI: A peptide sulfate salt obtained by combining leupeptin with 0.5 molar equivalents of sulfuric acid.
General Description
Leupeptin, or N-acetyl-L-leucyl-L-leucyl-L-argininal, is a naturally occurring tripeptide that acts particularly as a serine protease inhibitor and as a cysteine protease inhibitor. Its mechanism of action involves structurally similar covalent binding reactions:
- In the active site of serine proteases, leupeptin forms a covalent hemiacetal adduct between the aldehyde group of leupeptin and the hydroxyl group of a serine residue in the enzyme active site.
- In the active site of cysteine proteases, the electrophilic (aldehyde) carbon of leupeptin forms a comparable bond with the sulfur atom of a cysteine residue in the enzyme active site.
Leupeptin Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 288)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Otto Chemie Pvt Ltd | +91-2222070099 +91-2266382599 | Maharashtra, India | 429 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| zhuzhou dingcheng meihei comestic co.,ltd | +8618873369619 | China | 260 | 58 | Inquiry |
| Shanghai Getian Industrial Co., LTD | +86-15373193816 +86-15373193816 | China | 269 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29888 | 58 | Inquiry |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | China | 10311 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
103476-89-7(Leupeptin)Related Search:
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LEUPEPTIN
LEUPEPTIN TRIFLUOROACETATE FROM*MICROBIA L SOURCE,LEUPEPTIN TRIFLUOROACETATE SALT
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leupeptin hydrochloride from*microbial source,LEUPEPTIN HYDROCHLORIDE, HIGH PURITY,LEUPEPTIN HYDROCHLORIDE,Leupeptin hydrochloride >90%
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LEUPEPTIN HEMISULFATE MONOHYDRATE
PROPIONYL-LEUPEPTIN HEMISULFATE,LEUPEPTIN -PROPIONYL HEMISULFATE,Leupeptin/CH85402,propionyl-leupeptin hemisulfate salt,Leupeptin Pr-LL.
BOC-LEUPEPTIN
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AC-LEU-LEU-ARGININAL HEMISULPHATE
AC-LEU-LEU-ARGININAL X 1/2 H2SO4
AC-LEU-LEU-L-ARGININAL
AC-LLR-CHO
AC-LLR-CHO, 1/2H2 SO4
N-ACETYL-L-LEUCYL-L-LEUCYL-L-ARGININAL HEMISULFATE
Acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate
leupeptin hemisulfate from microbial*source
LEUPEPTIN HEMISULFATE, ~4000 U/MG
LEUPEPTIN HEMISULFATE SYNTHETIC
L-Leucinamide, N-acetyl-L-leucyl-N-(1S)-4-(aminoiminomethyl)amino-1-formylbutyl-, sulfate (2:1)
acetyl-leu-leu-arg-al
Leupeptin hemisulphate >90%
ACETYL-L-LEUCYL-L-LEUCYL-L-ARGININAL SULFATE
ACETYL-L-LEU-LEU-ARG (SULFATED)
ACETYL-LEU-LEU-ARG-AL HEMISULFATE
ACETYL-LEU-LEU-ARG-AL HEMISULFATE SALT
AC-LEU-LEU-ARG-ALDEHYDE
AC-LEU-LEU-ARG-ALDEHYDE HEMISULFATE
AC-LEU-LEU-ARG-CHO
AC-LEU-LEU-ARGININAL
LEUPEPTIN HEMISULFATE, MICROBIAL
Acetyl-Leu-Leu-Arg-al, N-Acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate salt
LeupeptinAcetyl-L-leucyl-L-leucyl-L-argininal hemisulfate
Leupeptin(Acetyl-Leu-Arginal)
TRIS-GLYCINE BUFFER 10X SOL. PROTEOMICS
N-acetyl-L-leucyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-formylbutyl]-L-leucinamide, sulfate (2:1)
EZNA KIT BACTERIAL RNA
LEUPEPTIN SULFATE
LEUPEPTIN (SYNTHETIC)
LEUPEPTIN
LEUPEPTIN 1/2 H2SO4
LEUPEPTIN HEMISULPHATE
LEUPEPTIN, 90%, SYNTHETIC
M.W. 475.59 C20H38N6O4 · 1/2H2SO4
Leupeptin hemisulfate salt,Acetyl-Leu-Leu-Arg-al, N-Acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate salt
Synonym Acetyl-Leu-L
Leupeptine hemisulfate
Leupeptin, Microbial
Acetyl-Leu-Leu-Arg-CHO
Leupeptin hemisulfate salt, 90%, reversible competitive serine/cysteine protease inhibitor
Acetyl-Leu-Leu-Arg-al, Leupeptin hemisulfate salt, N-Acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate salt
Leupeptin hemisulfate salt, ≥90%(HPLC)
CS-2263
Leupeptin, Hemisulfate, Microbial - CAS 103476-89-7 - Calbiochem
Leupeptin, Hemisulfate, Synthetic - CAS 103476-89-7 - Calbiochem
Leupeptin USP/EP/BP
Leupeptin (Acety1-Leu-Leu-Arginal)
Leupeptin Hemisulfate (NK381)
Ac-Leu-Leu-arginal, hemisulfate, Ac-Leu-Leu-Arginal
Leupeptin, ≥95% (HPLC)
Leupeptin hemisulfate anhydrous
LEUPEPTIN HEMISULFATE
LEUPEPTIN HEMISULFATE SALT
(S)-2-Acetamido-N-((S)-1-(((S)-5-guanidino-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-4-methylpentanamide hemisulfate
inhibit,Cathepsin,Leupeptin Hemisulfate,Inhibitor
103476-89-7
C20H38N6O412H2SO4