CLORAZEPATE DIPOTASSIUM SALT
- CAS No.
- 57109-90-7
- Chemical Name:
- CLORAZEPATE DIPOTASSIUM SALT
- Synonyms
- Azene;cm4306;cb4306;4306cb;ah3232;mendon;ab35616;latekoh;tr19119;belseren
- CBNumber:
- CB3737547
- Molecular Formula:
- C16H13ClK2N2O4
- Molecular Weight:
- 410.94
- MOL File:
- 57109-90-7.mol
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 228-235°C |
|---|---|
| Flash point | 11 °C |
| storage temp. | 2-8°C |
| solubility | Freely soluble to very soluble in water, very slightly soluble in alcohol, practically insoluble in methylene chloride. Solutions in water and in alcohol are unstable and are to be used immediately. |
| form | Solid |
| color | White to Pale Yellow |
| EPA Substance Registry System | Clorazepate dipotassium (57109-90-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H361 |
| Precautionary statements | P280-P301+P312+P330 |
| Hazard Codes | Xn,T,F |
| Risk Statements | 22-63-39/23/24/25-23/24/25-11 |
| Safety Statements | 22-36/37/39-45-36/37-16-7 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | DE8750000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 2933910000 |
| Toxicity | LD50 in mice (mg/kg): 700 orally; 290 i.p.; LD50 orally in rats: >1000 mg/kg (Brunaud) |
CLORAZEPATE DIPOTASSIUM SALT Chemical Properties,Uses,Production
Chemical Properties
Pale Yellow Solid
Uses
Anxiolytic. Controlled substance (depressant).
Definition
ChEBI: The compound of monopotassium clorazepate with potassium hydroxide. It is used for the management of anxiety disorders, for the short-term relief of anxiety, as adjunctive therapy in the management of epilepsy, and for the symptomatic relief of acute alcoh l withdrawal.
General Description
Clorazepate dipotassium,7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acid dipotassium salt monohydrate(Tranxene), can be considered a prodrug. Inactive itself, itundergoes rapid decarboxylation by the acidity of thestomach to nordazepam (a major active metabolite of diazepam),which has a long half-life and undergoes hepaticconversion to active oxazepam. Despite the polar characterof the drug as administered, because it is quickly convertedin the GI tract to an active nonpolar compound, it has aquick onset, overall long half-life, and shares similar clinicaland pharmacokinetic properties to chlordiazepoxideand diazepam.
CLORAZEPATE DIPOTASSIUM SALT Preparation Products And Raw materials
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