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ChemicalBook > Product Catalog >Biochemical Engineering >Polypeptide >NEUROPEPTIDE FF

NEUROPEPTIDE FF

NEUROPEPTIDE FF Structure
CAS No.
99566-27-5
Chemical Name:
NEUROPEPTIDE FF
Synonyms
NPFF;NPAF;ninamide;F-8-F-NH2;FLFQPQRF-NH2;NEUROPEPTIDE FF;Neuropeptide FF TFA;Neuropeptide FF (cattle);Neuropeptide FF F-8-F-NH2;NEUROPEPTIDE FF USP/EP/BP
CBNumber:
CB3750458
Molecular Formula:
C54H76N14O10
Molecular Weight:
1081.27
MOL File:
99566-27-5.mol
Modify Date:
2024/7/2 8:55:06
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NEUROPEPTIDE FF Properties

storage temp. −20°C
solubility Water: 1 mg/ml
form Solid
color White to off-white
Water Solubility Soluble to 0.50 mg/ml in water.

SAFETY

Risk and Safety Statements

WGK Germany  3

NEUROPEPTIDE FF Chemical Properties,Uses,Production

Description

Neuropeptide FF (NPFF) is a peptide expressed in the brain and spinal cord that shares a precursor protein with neuropeptide AF. NPFF is expressed primarily in the posterior pituitary, hypothalamus, and medulla. It is an agonist at NPFF1 and NPFF2 receptors (Kis = 2.82 and 0.21 nM, respectively, for human recombinant receptors) that inhibits forskolin-induced cAMP production in CHO cells (EC50s = 236 and 2.3 nM, respectively). NPFF activates parvocellular neurons in the paraventricular nucleus (PVN) of the hypothalamus to stimulate oxytocin release from their projections in the brain stem, thereby regulating baroreflex control of heart rate. However, it inhibits magnocellular PVN neurons by enhancing GABAergic input. It is also found in plasma and exogenous administration briefly increases mean arterial pressure (MAP) by 40 mm Hg in rats, an effect that is only partially blocked by the norepinephrine competitor guanethidine and the α1-adrenergic receptor antagonist prazosin . NPFF has anti-opioid effects in rodent models, inhibiting morphine-induced analgesia and inducing abstinence in morphine-tolerant rats. It also inhibits acquisition of conditioned place preference to cocaine in rats when administered at doses of 10 and 20 nmol.

Uses

Endogenous antiopioid peptide and agonist at NPFF1 and NPFF2 receptors (Ki values are 2.82 and 0.21 nM respectively). Exhibits anorexigenic effects.

NEUROPEPTIDE FF Preparation Products And Raw materials

Raw materials

Preparation Products

NEUROPEPTIDE FF Suppliers

Global( 104)Suppliers
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Shenzhen Nexconn Pharmatechs Ltd +86-755-89396905 +86-15013857715 China 10259 58 Inquiry
Cellmano Biotech Limited 0551-65326643 18156095617 China 999 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26368 58 Inquiry
BOC Sciences 16314854226; +16314854226 United States 19743 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
Chengdu Youngshe Chemical Co., Ltd. +8618108235634 China 2345 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
ZHEJIANG JIUZHOU CHEM CO., LTD +86-0576225566889 +86-13454675544 China 19947 58 Inquiry
GIHI CHEMICALS CO.,LIMITED +8618058761490 China 49999 58 Inquiry
Supplier Advantage
Shenzhen Nexconn Pharmatechs Ltd 58
Cellmano Biotech Limited 58
career henan chemical co 58
Dideu Industries Group Limited 58
BOC Sciences 58
Zhejiang J&C Biological Technology Co.,Limited 58
Chengdu Youngshe Chemical Co., Ltd. 58
TargetMol Chemicals Inc. 58
ZHEJIANG JIUZHOU CHEM CO., LTD 58
GIHI CHEMICALS CO.,LIMITED 58

99566-27-5(NEUROPEPTIDE FF)Related Search:

NEUROPEPTIDE AF (HUMAN) NEUROPEPTIDE Y (13-36), PORCINE SYNTHETI C >97% PANCREATIC POLYPEPTIDE, RAT SUBSTANCE P (2-11) SUBSTANCE P (6-11)
Substance P (1-7)(TFA) substance P (3-11) (LEU31,PRO34)-NEUROPEPTIDE Y (HUMAN, RAT) Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA Galanin (1-16), mouse, porcine, rat TFA
NEUROPEPTIDE F GALANIN, PORCINE GLY-LEU-MET-NH2 H-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-ILE-THR-ARG-GLN-ARG-TYR-NH2 H-LEU-PRO-GLY-LEU-PRO-SER-ALA-ALA-SER-SER-GLU-ASP-ALA-GLY-GLN-SER-NH2
SUBSTANCE P (1-9) SUBSTANCE P NEUROPEPTIDE Y (HUMAN, RAT)
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PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE AMIDE PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2 NPFF NEUROPEPTIDE FF H-PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2 F-8-F-NH2 ninamide phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylala POTASSIUM FERROCYANIDE TRIHYDRATE*ACS RE AGENT Neuropeptide FF F-8-F-NH2 phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide Neuropeptide FF Morphine Modulating Neuropeptide F-8-F-NH2 Neuropeptide FF F-8-F-NH2, NPFF, F-8-F-aMide F-8-F-NH2, NPFF, F-8-F-aMide ANTI-NPFF (C-TERM) antibody produced in rabbit FMRFamide-related peptides NPAF Neuropeptide FF (trifluoroacetate salt) L-Phenylalaninamide, L-phenylalanyl-L-leucyl-L-phenylalanyl-L-glutaminyl-L-prolyl-L-glutaminyl-L-arginyl- Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe amide >=95% (HPLC) NEUROPEPTIDE FF USP/EP/BP Neuropeptide FF (cattle) Rabbit Anti-NPFF antibody FLFQPQRF-NH2 Neuropeptide FF trifluoroacetate salt (NPFF) Neuropeptide FF TFA 99566-27-5 C54H76N14O10 BioChemical Amino Acids and Peptides Biochemicals and Reagents Other Peptides Peptides Peptide