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PD 166793

CAS No.: 199850-67-4

Chemical Name:: PD 166793

Synonyms: PD 166793;PD-166793-0000;PD 166793 USP/EP/BP;MMP-2/MMP-3 Inhibitor;N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine;L-Valine, N-[(4'-bromo[1,1'-biphenyl]-4-yl)sulfonyl]-;(S)-2-(4'-bromobiphenyl-4-ylsulfonamido)-3-methylbutanoic acid;(2S)-2-[[4-(4-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoicaci;(S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid;(S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid

CBNumber:: CB3840520

Molecular Formula:: C17H18BrNO4S

Molecular Weight:: 412.3

MOL File:: 199850-67-4.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:07

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PD 166793 Properties

Melting point	192-193℃
Density	1.457
storage temp.	Sealed in dry,2-8°C
solubility	DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml
form	A crystalline solid
color	White to pink

PD 166793 price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	444284	MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem The MMP-2/MMP-3 Inhibitor III, PD166793, also referenced under CAS 199850-67-4, controls the biological activity of MMP-2/MMP-3. This small molecule/i	199850-67-4	5MG	₹17860	2022-06-14	Buy

Product number	Packaging	Price	Buy
444284	5MG	₹17860	Buy

PD 166793 Chemical Properties,Uses,Production

Uses

PD 166793 is a matrix metalloproteinase inhibitor in the treatment of inflammatory pathological occurrences involving blood pressure and the cardiac system.

General Description

A cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC₅₀ = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 μM), MMP-1, -7, -9, and -14 (IC₅₀ = 6.1, 7.2, 7.9, and 0.24 μM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes.

Biological Activity

Broad spectrum matrix metalloprotease (MMP) inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC 50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure.

PD 166793 Preparation Products And Raw materials

Raw materials

Preparation Products

PD 166793 Suppliers

Global( 61)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Alpha Biopharmaceuticals Co., Ltd	+86-15542445688	China	888	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	China	30253	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	25247	58	Inquiry
Nextpeptide Inc	+86-0571-81612335 +8613336028439	China	19915	58	Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	China	49739	58	Inquiry
GIHI CHEMICALS CO.,LIMITED	+8618058761490	China	49999	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	57511	58	Inquiry
Shanghai Aladdin Biochemical Technology Co.,Ltd.	+86-18521732826	China	48467	58	Inquiry
Henan Alpha Chemical Co., Ltd.	0371-55013243 15324716602	China	10010	58	Inquiry

Supplier	Advantage
Alpha Biopharmaceuticals Co., Ltd	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Dideu Industries Group Limited	58
Nextpeptide Inc	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
GIHI CHEMICALS CO.,LIMITED	58
Aladdin Scientific	58
Shanghai Aladdin Biochemical Technology Co.,Ltd.	58
Henan Alpha Chemical Co., Ltd.	58

199850-67-4(PD 166793)Related Search:

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PD 166793 (S)-2-(4'-bromobiphenyl-4-ylsulfonamido)-3-methylbutanoic acid N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine (S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid MMP-2/MMP-3 Inhibitor L-Valine, N-[(4'-bromo[1,1'-biphenyl]-4-yl)sulfonyl]- (2S)-2-[[4-(4-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoicaci PD 166793 USP/EP/BP PD-166793-0000 (S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid 199850-67-4 Angiogenesis and Metastasis Protease inhibitor