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platyphylline

platyphylline Structure
CAS No.
480-78-4
Chemical Name:
platyphylline
Synonyms
Platifillin;Platiphyllin;Platiphillin;Platyphyllin;platyphylline;Einecs 207-558-6;66641-38-1 (Hydrochloride);PLATYPHYLLINI HYDROTARTRAS;12-Hydroxy-1,2-dihydrosenecionan-11,16-dione;(1R)-1,2-Dihydro-12-hydroxysenecionan-11,16-dione
CBNumber:
CB3914285
Molecular Formula:
C18H27NO5
Molecular Weight:
337.41
MOL File:
480-78-4.mol
MSDS File:
SDS
Modify Date:
2023/5/15 10:43:30
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platyphylline Properties

Melting point 129°
alpha D20 -56.4° (c = 0.7 in chloroform)
Boiling point 539.6±50.0 °C(Predicted)
Density 1.22±0.1 g/cm3(Predicted)
pka 12.83±0.40(Predicted)

SAFETY

Risk and Safety Statements

RIDADR  1544
HazardClass  6.1(b)
PackingGroup  III

platyphylline Chemical Properties,Uses,Production

Description

A hepatotoxic alkaloid, the base has been isolated from Senecio adnatus D.C., S. hygrophilus Dyer & Sm. and S. piatyphyllus D.C. The alkaloid is only sparingly soluble in petroleum ether or hot H20, more so in Me2CO, EtOH, C6H6 or Et20 and readily soluble in CHCI3. It is laevorotatory with [α]D - 45.09° (CHCI3). The perchlorate occurs as colourless prisms from H20, m.p. 222-3°C (dec.); the picrolonate, dark yellow needles, m.p. 205-6°C (dec.); aurichloride, m.p. 200-loC (dec.) and the methiodide, m.p. 216-7°C; [α]D - 31.27° (EtOH). The alkaloid contains one hydroxyl group but no methoxyl or methylimino groups. On hydrolysis it furnishes platynecine, CSH1S0 2N, m.p. 148°C; [α]D - 56.8° (CHCI3) and platynecic acid, ClOH140 4 , m.p. l54-5°C which is identical with senecic acid lactone.

References

Orekhov, Tiedebel., Ber., 68,653 (1935)
Orekhov, Konovalova, Tiedebel., ibid, 68, 1886 (1935)
Orekhov, Tiedebel., J. Gen. Chern. USSR, 8,273 (1938)
de Waal., Onderstepoort J., 15,251 (1940)
Koekemoer, Warren., J. Chern. Soc., 63 (1955)

platyphylline Preparation Products And Raw materials

Raw materials

Preparation Products

platyphylline Suppliers

Global( 22)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CHEMSWORTH +91-261-2397244 New Delhi, India 6707 30 Inquiry
AFINE CHEMICALS LIMITED +86-0571-85134551 China 15395 58 Inquiry
Shaanxi Didu New Materials Co. Ltd +86-89586680 +86-13289823923 China 9003 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
GIHI CHEMICALS CO.,LIMITED +8618058761490 China 49999 58 Inquiry
Shanghai Yanchun Biopharmaceutical Technology Co., Ltd 4001-009266 17349750668 China 2811 58 Inquiry
Chengdu Push Bio-Technology Co., Ltd. 18080489829 China 9209 58 Inquiry
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd 17691182729 18161915376 China 10011 58 Inquiry
Changzhou Xianglong Pharmaceutical Technology Co., LTD 0519-88910898 18661161657 China 9998 58 Inquiry
Wuhan ChemFaces Biochemical Co., Ltd. 18607101326 15172504745 China 7059 55 Inquiry
Supplier Advantage
CHEMSWORTH 30
AFINE CHEMICALS LIMITED 58
Shaanxi Didu New Materials Co. Ltd 58
TargetMol Chemicals Inc. 58
GIHI CHEMICALS CO.,LIMITED 58
Shanghai Yanchun Biopharmaceutical Technology Co., Ltd 58
Chengdu Push Bio-Technology Co., Ltd. 58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd 58
Changzhou Xianglong Pharmaceutical Technology Co., LTD 58
Wuhan ChemFaces Biochemical Co., Ltd. 55

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platyphylline (1R)-1,2-Dihydro-12-hydroxysenecionan-11,16-dione [1R,(-)]-1,2-Dihydro-12-hydroxysenecionan-11,16-dione Platifillin (1-alpha)-1,2-Dihydro-12-hydroxysenecionan-11,16-dione 66641-38-1 (Hydrochloride) Einecs 207-558-6 Platiphillin Platiphyllin Senecionan-11,16-dione, 1,2-dihydro-12-hydroxy-, (1-alpha)- 12-Hydroxy-1,2-dihydrosenecionan-11,16-dione Platyphyllin [1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, 3-ethylidenedodecahydro-6-hydroxy-5,6-dimethyl-, (3Z,5R,6R,9aS,14aR,14bR)- PLATYPHYLLINI HYDROTARTRAS 480-78-4