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Afurolol

Afurolol Structure
CAS No.
65776-67-2
Chemical Name:
Afurolol
Synonyms
Afurolol;Afurololum;7-[3-(tert-Butylamino)-2-hydroxypropoxy]isobenzofuran-1(3H)-one;1(3H)-Isobenzofuranone, 7-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-
CBNumber:
CB41116269
Molecular Formula:
C15H21NO4
Molecular Weight:
279.33154
MOL File:
65776-67-2.mol
Modify Date:
2022/12/21 16:56:50
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Afurolol Chemical Properties,Uses,Production

Originator

Afurolol ,ZYF Pharm Chemical

Manufacturing Process

A mixture of 18.0 g (0.12 mole) 7-hydroxyphthalide, 180.0 g of 1-chloro-2,3- epoxypropane (2 moles) and 0.5 ml of piperidine is heated at 100°C for about 5 h and then the unreacted 1-chloro-2,3-epoxypropane is distilled off in vacuum to yield 12.0 g (48%) of 7-(2,3-epoxypropoxy)phthalide, melting point 88°-90°C, (crystallized successively from methanol and ethyl acetate).
The 7-(2,3-epoxypropoxy)phthalide is dissolved in methanol and t-butylamine are added to the solution at about 20°C. The solution is allowed to stand overnight and, the mixture is evaporated in vacuum and the residue is dried to give 7-(2-hydroxy-3-t-butylamino-propoxy)phthalide.

Therapeutic Function

Beta-adrenergic blocker

Afurolol Preparation Products And Raw materials

Raw materials

1-CHLORO-2,5-DIMETHYL-4-NITROBENZENE2-CHLORO-5-NITRO-P-XYLENE tert-Butylamine 7-hydroxyphthalide Epichlorohydrin

Preparation Products

Afurolol Suppliers

Global( 8)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd. +86-057181025280; +8617767106207 China 49739 58 Inquiry
TargetMol Chemicals Inc. 4008200310 China 24017 58 Inquiry
3B Scientific Corporation 847.281.9822 United States 6744 47 Inquiry
2A PharmaChem USA (630) 737-0988 United States 6148 39 Inquiry
Lanospharma Laboratories Co.,Ltd 13440048448 China 6343 56 Inquiry
Leancare Ltd. +33 962096793 United Kingdom 6460 42 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 58
TargetMol Chemicals Inc. 58
3B Scientific Corporation 47
2A PharmaChem USA 39
Lanospharma Laboratories Co.,Ltd 56
Leancare Ltd. 42

65776-67-2(Afurolol)Related Search:

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Afurolol 7-[3-(tert-Butylamino)-2-hydroxypropoxy]isobenzofuran-1(3H)-one 1(3H)-Isobenzofuranone, 7-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]- Afurololum 65776-67-2