Maropitant citrate hydrate
- CAS No.
- 359875-09-5
- Chemical Name:
- Maropitant citrate hydrate
- Synonyms
- 2-HYDROXYPROPANE-1,2,3-TRICARBOXYLIC ACID;ethyl[(1R)-1-[(2R)-oxolan-2-yl]-2-phenylethyl]amine;4-(4-fluorophenyl)-1-[4-(1,2,4-triazol-1-yl)butyl]-3,6-dihydro-2H-pyridine;(7S,8S)-7-benzhydryl-N-[(2-methoxy-5-tert-butyl-phenyl)methyl]-1-azabicyclo[2.2.2]octan-8-amine;Maropitant citrate hydrate;ACIDUM CITRICUM ANHYDRICUM;(2S,3S)-N-(5-tert-butyl-2-methoxybenzyl)-2-(diphenylmethyl)-...;(2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine,2-hydroxypropane-1,2,3-tricarboxylic acid,hydrate;FEMA 2306;CT SUPPLEMENT
- CBNumber:
- CB4127749
- Molecular Formula:
- C38H48N2O8
- Molecular Weight:
- 660.81
- MOL File:
- 359875-09-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/4/8 16:27:35
| Melting point | 153-159 °C(lit.) |
|---|---|
| Flash point | 100 °C |
| storage temp. | 2-8°C |
| solubility | H2O: 1 M at 20 °C, clear, colorless |
| form | white to off-white crystalline powder |
| Water Solubility | Water: 3 mg/mL (4.42 mM) |
| InChIKey | XDZPFSKCXRGRIO-OHTRWSNQNA-N |
| SMILES | C(O)(C(=O)O)(CC(=O)O)CC(=O)O.C(C1C=CC=CC=1)(C1C=CC=CC=1)[C@@H]1N2CCC(CC2)[C@@H]1NCC1C=C(C(C)(C)C)C=CC=1OC |&1:26,33,r| |
| CAS DataBase Reference | 359875-09-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS08,GHS09,GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H400-H373-H318-H410 |
| Precautionary statements | P273-P391-P501-P273-P391-P501-P260-P314-P501-P280-P305+P351+P338-P310 |
| Hazard Codes | Xi,T |
| Risk Statements | 41-42/43-36/37/38-25 |
| Safety Statements | 26-39-45-36/37-22 |
| RIDADR | UN 3284 6.1/PG 3 |
| WGK Germany | 1 |
| RTECS | GE7350000 |
| F | 9 |
Maropitant citrate hydrate Chemical Properties,Uses,Production
Description
Maropitant citrate hydrate is a specific neurokinin-1 (NK-1) receptor antagonist that selectively inhibits the production of substance P, a mediator involved in signalling vomiting. Maropitant citrate was therefore originally used to treat vomiting in dogs and cats. Currently, it is also used as an adjunct to visceral analgesia in dogs and cats, and in other species such as horses and birds.
Uses
Anti-emetic.
Pharmacokinetics
The maximum, minimum, and average concentrations of maropitant achieved at steady state were 375.5 ± 200, 16.8 ± 7.7, and 73.5 ± 45.1 ng/ml, respectively. The terminal elimination half-life was 11.6 ± 1.4 hr, and the accumulation index was 1.3 ± 0.07. Heart rate decreased between Day 1 and Day 5 (p = .005), with three horses having heart rates of 20 beats per minute and atrioventricular block on Day 5. Pharmacokinetics of repeated maropitant administration suggests the drug could be considered for use in healthy horses.
Veterinary Drugs and Treatments
Maropitant citrate injectable solution is indicated for the prevention and treatment of acute vomiting in dogs; maropitant citrate tablets are indicated for the prevention of acute vomiting and the prevention of vomiting due to motion sickness in dogs. Both are also used extra-label in cats.
Maropitant citrate hydrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Euroasia Trans Continental | +91 22 56349035-36 | New Delhi, India | 519 | 47 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Chengdu Aslee Biopharmaceuticals, Inc. | 28-85305008 | CHINA | 964 | 58 | Inquiry |
| Hpets Biotech Company (Chongqing) Co.,ltd | +8613340353813 | China | 26 | 58 | Inquiry |
| Tianjin Kilo Pharmaceutical Sci-Tech Co., Ltd | +86-02223869539 +86-15560057295 | China | 27 | 58 | Inquiry |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | China | 6011 | 58 | Inquiry |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20324 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21675 | 55 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |