Rimonabant
- CAS No.
- 168273-06-1
- Chemical Name:
- Rimonabant
- Synonyms
- A 281;xibuqum;ACOMPLIA;Sr 141716;rimobrant;Rimonaban;RIMONABANT;Limonabant;Unii-rml78en3xe;Rimonabant base
- CBNumber:
- CB4129374
- Molecular Formula:
- C22H21Cl3N4O
- Molecular Weight:
- 463.79
- MOL File:
- 168273-06-1.mol
- Modify Date:
- 2024/11/4 20:04:50
| Melting point | 154.7 °C |
|---|---|
| Density | 1.41±0.1 g/cm3(Predicted) |
| storage temp. | RT |
| solubility | Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml). |
| pka | 11.31±0.20(Predicted) |
| form | solid |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| CAS DataBase Reference | 168273-06-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H410-H372 |
| Precautionary statements | P260-P264-P270-P314-P501-P273-P391-P501 |
Rimonabant Chemical Properties,Uses,Production
Description
Rimonabant is a first-in-class drug launched as an oral treatment for obesity, and its mechanism of action involves the selective antagonism of cannabinoid type 1 (CB1) receptor. It is specifically indicated as an adjunct to diet and exercise for the treatment of obese patients (body mass index [BMI]≥30 kg/m2), or overweight patients (BMI＞27 kg/m2) with associated risk factors such as type 2 diabetes or dyslipidemia. Additionally, rimonabant is currently under development as a treatment for nicotine dependence. The CB1 and CB2 receptors, along with their endogenous ligands, constitute the endocannabinoid system. The CB1 receptor is expressed in the brain, adipose tissue, and several peripheral organs; the CB2 receptor is predominantly expressed in immune cells. Activation of the CB1 receptor in the CNS is associated with appetite stimulation and the modulation of brain reward mechanism, whereas activation in the periphery favors metabolic processes that lead to hepatic lipogenesis and impaired glucose homeostasis. Rimonabant acts by selectively blocking the action of central and peripheral CB1 receptors, thereby reducing food intake and improving lipid and glucose metabolism.
Uses
Rimonabant is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane
Rimonabant Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Alfa Omega Pharma | +91-8050045945 +91-9972665399 | Maharashtra, India | 126 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6100 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12837 | 58 | Inquiry |
| Hong Kong Excellence Biotechnology Co., Ltd. | China | 875 | 58 | Inquiry | |
| Sigma Audley | +86-15937194204 +86-18126314766 | China | 493 | 58 | Inquiry |
| Shanghai Aosiris new Material Technology Co., LTD | 86-15139564871 +8615139564871 | China | 109 | 58 | Inquiry |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +86-15350851019 +86-15383190639 | China | 1000 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21638 | 55 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32951 | 60 | Inquiry |
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