Dapoxetine hydrochloride
- CAS No.
- 129938-20-1
- Chemical Name:
- Dapoxetine hydrochloride
- Synonyms
- DAPOXETINE HCL;Dapoxetin HCl;Priligy;DL-Dapoxteine HCL;Dapoxetine HCL (Priligy);LY-21044;LY-210448;Dapoxetine HCI;Rimonabant 75000;Dapoxetine HCL-IHS
- CBNumber:
- CB7104314
- Molecular Formula:
- C21H24ClNO
- Molecular Weight:
- 341.88
- MOL File:
- 129938-20-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/8 13:40:43
| Melting point | 175-1790C |
|---|---|
| alpha | D +135.78° (c = 2.18 in methanol) |
| storage temp. | room temp |
| solubility | DMSO: ≥20mg/mL |
| form | powder |
| color | white |
| optical activity | [α]/D +125 to +135°, c = 1 in methanol |
| Merck | 14,2821 |
| InChI | InChI=1/C21H23NO.ClH/c1-22(2)20(18-10-4-3-5-11-18)15-16-23-21-14-8-12-17-9-6-7-13-19(17)21;/h3-14,20H,15-16H2,1-2H3;1H/t20-;/s3 |
| InChIKey | IHWDIQRWYNMKFM-OZYVVJTJNA-N |
| SMILES | O(C1=CC=CC2C=CC=CC1=2)CC[C@@H](C1C=CC=CC=1)N(C)C.Cl |&1:13,r| |
| CAS DataBase Reference | 129938-20-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319-H413 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-36-50/53 | |||||||||
| Safety Statements | 36-60-61 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29221990 | |||||||||
| NFPA 704 |
|
Dapoxetine hydrochloride price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D7071 | Dapoxetine hydrochloride ≥98% (HPLC) | 129938-20-1 | 10MG | ₹11961.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D7071 | Dapoxetine hydrochloride ≥98% (HPLC) | 129938-20-1 | 50MG | ₹46753.18 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D4761 | Dapoxetine Hydrochloride | 129938-20-1 | 1G | ₹10700 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D4761 | Dapoxetine Hydrochloride | 129938-20-1 | 5G | ₹14500 | 2022-05-26 | Buy |
Dapoxetine hydrochloride Chemical Properties,Uses,Production
Description
Dapoxetine hydrochloride, belonging to the class of SSRIs, was the first drug originally approved for the on-demand treatment of men with PE by seven European countries in 2008.
Premature ejaculation (PE) is the most common male sexual dysfunction. Dapoxetine is a short-acting SSRI. It is differentiated from the existing SSRI treatments for PE by the fact that it can be administered on an as-needed basis. In healthy subjects, dapoxetine is rapidly absorbed after oral administration with a peak plasma concentration (Tmax) occurring between 1.4 and 2h.
Chemical Properties
Dapoxetine hydrochloride is a white to slightly yellow powder. It is freely soluble in methanol, propylene glycol, some organic solvents (eg. N,N-dimethylformamide) , slightly soluble in ethanol and almost insoluble in water. It is a BCSI class II compound, and poor solubility is a key factor affecting the difference in clinical efficacy. Dapoxetine hydrochloride exists in various crystal forms, the solubility of different crystal forms is quite different, and there is a phenomenon of phase and transformation between crystal forms.
Uses
Dapoxetine hydrochloride is a short-acting novel selective serotonin reuptake inhibitor marketed for the treatment of premature ejaculation in men. Premature ejaculation (PE) is the most common male sexual disorder, estimated to affect up to 30% of men.
General Description
Dapoxetine ((+)-(S)-N,N-dimethyl-(α)-[2(1naphthal enyloxy)ethyl]-benzenemethanamine hydrochloride) possess a similar structure as that of fluoxetine.
Mode of action
The mechanism of action of dapoxetine in premature ejaculation is presumed to be linked to the inhibition of neuronal reuptake of serotonin and the subsequent potentiation of the neurotransmitter's action at pre- and post-synaptic receptors. Dapoxetine is a centrally-acting SSRI that modulates serotonin levels in relevant areas such as the lateral paragigantocellular nucleus through inhibition of the serotonin transporter (SERT). This compound also decreases peak amplitude and accelerates the decay rate of current inactivation in a variety of voltage-gated K+ channels.
Dapoxetine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SGMR PHARMACEUTICALS PVT LTD | +91-9032001889 +91-9032001889 | Telangana, India | 83 | 58 | Inquiry |
| AARTIA KEM SCIENCE | +91-8291072530 +91-8291072530 | Maharashtra, India | 70 | 58 | Inquiry |
| Gonane Pharma | +91-9819380043 +91-9819380043 | NaviMumbai, India | 192 | 58 | Inquiry |
| Viyash Life Sciences Pvt Ltd | +91-4023635052 +91-4023635052 | Telangana, India | 213 | 58 | Inquiry |
| R L Fine Chem Pvt. Ltd | +91-8042488999 +91-8042488999 | Karnataka, India | 74 | 58 | Inquiry |
| Venture Pharmaceuticals pvt ltd | +91-9173909075 +91-9173909075 | Gujarat, India | 45 | 58 | Inquiry |
| Nosch Labs Pvt Ltd | +91-4048557474 +91-9948222287 | Hyderabad, India | 58 | 58 | Inquiry |
| Horster Biotek Pvt Ltd | +91-7359657360 +91-9898127219 | Gujarat, India | 58 | 58 | Inquiry |
| HRV Global Life Sciences | +91-9820219686 +91-9820219686 | Telangana, India | 379 | 58 | Inquiry |
| Sintilla Medcoms Pvt Ltd | +91-4027808001 +91-8886733867 | Telangana, India | 307 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| SGMR PHARMACEUTICALS PVT LTD | 58 |
| AARTIA KEM SCIENCE | 58 |
| Gonane Pharma | 58 |
| Viyash Life Sciences Pvt Ltd | 58 |
| R L Fine Chem Pvt. Ltd | 58 |
| Venture Pharmaceuticals pvt ltd | 58 |
| Nosch Labs Pvt Ltd | 58 |
| Horster Biotek Pvt Ltd | 58 |
| HRV Global Life Sciences | 58 |
| Sintilla Medcoms Pvt Ltd | 58 |