Lexithromycin
- CAS No.
- 53066-26-5
- Chemical Name:
- Lexithromycin
- Synonyms
- Wy 48314;Lexithromycin;Erythromycin A-E-oxime;Azithromycin Impurity 4;Azithromycin Impurity 31;erythromycin A methoxime;Erythromycin A 9-Methoxime;Erythromycin, 9-(O-methyloxime);9-(Methoxyimino)-9-deoxoerythromycin;ErythroMycin A 9-MethoxiMe, Wy 48314
- CBNumber:
- CB41327717
- Molecular Formula:
- C38H70N2O13
- Molecular Weight:
- 762.97
- MOL File:
- 53066-26-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/18 11:31:21
| Melting point | >115°C (dec.) |
|---|---|
| Boiling point | 824.6±75.0 °C(Predicted) |
| Density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| pka | 13.19±0.70(Predicted) |
| form | Solid |
| color | White to Off-White |
| Stability | Hygroscopic |
Lexithromycin Chemical Properties,Uses,Production
Description
Lexithromycin is a semisynthetic antibiotic derived from erythromycin . Lexithromycin has improved absorption in vivo over erythromycin due to increased hydrophopicity and pH stability. As with other macrolides, lexithromycin prevents protein synthesis by binding the ribosome at the polypeptide exit tunnel. Formulations containing lexithromycin were tested in clinical trials as treatment for HIV but were discontinued.
Uses
Lexithromycin is an early semi-synthetic erythromycin, prepared by reaction of the 9-keto moiety to methyl oxime. The structural change improves the pH stability profile and hydrophobicity of lexithromycin for better in vivo absorption. This same rationale was used to greater effect with roxithromycin and, as a result, lexithromycin was quickly superseded and has not been not extensively studied. Like all tetracyclines, lexithromycin shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.
Lexithromycin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | China | 13095 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | China | 11927 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 4008200310 | China | 24017 | 58 | Inquiry |
| Cayman Chemical Company | (800) 364-9897 | United States | 6618 | 81 | Inquiry |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | China | 8740 | 58 | Inquiry |
| TOSUN PHARM | 020-61855200 13326451905 | China | 7565 | 58 | Inquiry |
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