ChemicalBook > Product Catalog >Organic Chemistry >Amides >Acyclic polyamines and their derivatives >1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE

1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE

CAS No.: 4506-66-5

Chemical Name:: 1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE

Synonyms: 1,2,4,5-Benzenetetraamine tetrahydrochloride;Benzene-1,2,4,5-tetraamine tetrahydrochloride;Y15;FAK Inhibitor 14;1,2,4,5-TETRAAMINOBENZENE TETRAHYDROCHLORIDE;Y-15;NSC 667249;FAK inhibitor Y15;Y15 tetrahydrochloride;Benzene-1,2,4,5-tetrayL

CBNumber:: CB4137959

Molecular Formula:: C6H11ClN4

Molecular Weight:: 174.63

MOL File:: 4506-66-5.mol

MSDS File:: SDS

Modify Date:: 2023/8/24 17:20:48

Request For Quotation

1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE Properties

Melting point	≥300 °C(lit.)
storage temp.	room temp
solubility	H2O: soluble20mg/mL, clear
form	powder
color	, faint purple to dark brown
BRN	3701344
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
InChIKey	BZDGCIJWPWHAOF-UHFFFAOYSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS05

Signal word

Danger

Hazard statements

H225-H314

Precautionary statements

P210-P233-P240-P241-P242-P243-P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P370+P378-P403+P235-P405-P501

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

NFPA 704

	0
2		0

1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE price More Price(5)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SML0837	FAK Inhibitor 14 ≥95% (HPLC)	4506-66-5	10MG	₹7068.73	2022-06-14	Buy
Sigma-Aldrich(India)	SML0837	FAK Inhibitor 14 ≥95% (HPLC)	4506-66-5	50MG	₹28956.88	2022-06-14	Buy
Sigma-Aldrich(India)	324877	Focal Adhesion Kinase Inhibitor I - CAS 4506-66-5 - Calbiochem The Focal Adhesion Kinase Inhibitor I, also referenced under CAS 4506-66-5, controls the biological activity of Foca Adhesion Kinase. This small molec	4506-66-5	5MG	₹8310	2022-06-14	Buy
Sigma-Aldrich(India)	305065	1,2,4,5-Benzenetetramine tetrahydrochloride ≥95%	4506-66-5	1G	₹11539.45	2022-06-14	Buy
Sigma-Aldrich(India)	305065	1,2,4,5-Benzenetetramine tetrahydrochloride ≥95%	4506-66-5	5G	₹37811.73	2022-06-14	Buy

Product number	Packaging	Price	Buy
SML0837	10MG	₹7068.73	Buy
SML0837	50MG	₹28956.88	Buy
324877	5MG	₹8310	Buy
305065	1G	₹11539.45	Buy
305065	5G	₹37811.73	Buy

1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE Chemical Properties,Uses,Production

Uses

FAK Inhibitor 14 directly blocks phosphorylation of focal adhesion kinase (FAK) in a dose- and time-dependent manner and has also shown breast tumor regression in vivo. It has been suggested that targeting the Y397 site of FAK with FAK Inhibitor 14 can be effectively used in cancer therapy.

General Description

A cell-permeable tetraamine compound that is identified from a computer-aided molecular docking screening based on Fak Y397 interaction and is shown to inhibit FAK (Cat. No. 324876) autophosphorylation as well as its kinase activity toward paxillin phosphorylation both in cell-free kinase assays (IC₅₀<1 μM) and in BT474 breast cancer cultures, while exhibiting little activity against Pyk2 (Cat. No. 662067) autophosphorylation or the kinase activity of c-Raf, c-Src, EGFR, VEGFR-3, IGF-1, Met, PDGFR-α, Pyk2, and PI 3-K (p110δ/p85α). Reported to inhibit BT474 proliferation both in cultures in vitro (IC₅₀ ~10 μM) and in mice in vivo (~25% of no treatment controls on day 23; 30 mg/kg via 5 i.p/wk).

Biological Activity

Selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. Prevents FAK autophosphorylation at Y397 (IC 50 = 1 μ M), promotes cell detachment and inhibits cell adhesion in vitro . Exhibits antiproliferative activity in a variety of human tumor cell lines in vitro and in breast cancer cells in vivo .

1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

4,6-dinitrobenzene-1,3-diamine 1,3-Dichlorobenzene

Preparation Products

Benzo[1,2-d:4,5-d]diimidazole-2,6(1H,3H)-dione, 5,7-dihydro- (6CI,9CI) 1,4-Cyclohexadiene-1,4-diamine, 3,6-diimino- Diquinoxalino[2,3-a:2',3'-c]phenazine-2,3,8,9,14,15-hexamine

1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE Suppliers

Global( 201)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Alfa Chemistry	+1-5166625404	United States	21317	58	Inquiry
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	China	12460	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29900	58	Inquiry
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	China	8828	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
CHEMSOON CO.,LTD.	+8613761723174	China	1211	58	Inquiry
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	China	10297	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
Alfa Chemistry	58
Hebei Mojin Biotechnology Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Hebei Guanlang Biotechnology Co., Ltd.	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
CHEMSOON CO.,LTD.	58
Fuxin Pharmaceutical	58

1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE Spectrum

1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE(4506-66-5)¹HNMR 1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE(4506-66-5)IR

4506-66-5(1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE)Related Search:

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1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE benzene-1,2,4,5-tetrayltetraamine tetrahydrochloride 1,2,4,5-BENZENETETRAMINE TETRAHYDRO-CHLO RIDE, TECH. 1,2,4,5-BenzenetetraminetetraHCl 1,2,4,5-Benzenetetramine tetrahydrochloride, 1,2,4,5-Tetraaminobenzene tetrahydrochloride (2,4,5-triaminophenyl)amine tetrahydrochloride benzene-1,2,4,5-tetramine tetrahydrochloride 1,2,4,5-Benzenetetramine tetrahydrochloride ,98% 1,2,4,5-Benzenetetramine tetrahydrochloride,1,2,4,5-Benzenetetramine tetrahydrochloride, 1,2,4,5-Tetraaminobenzene tetrahydrochloride Benzene-1,2,4,5-tetraMine 4HCl FAK inhibitor Y15 Y-15 1,2,4,5-BenzenetetraMine tetrahydrochloride technical grade 1,2,4,5-Benzenetetraamine 4HCl NSC 667249 Focal Adhesion Kinase Inhibitor I 1;2;4;5-TETRAAMINOBENZENE TETRA HYDROCHLORIDE;FAK INHIBITOR Y15;Y15 5-tetraaminobenzene tetra hydrochloride Benzol-1,2,4,5-tetramintetrahydrochlorid FAK INHIBITOR Y15;Y-15;FAK INHIBITOR 14 Focal Adhesion Kinase Inhibitor I - CAS 4506-66-5 - Calbiochem 1,2,4,5-Benzenetetramine tetrahydrochlor Benzene-1,2,4,5-tetrayL tetraamine tetrahydrochL 1,2,4,5-BENZENETETRAMINE TETRAHYDROCHLORIDE ISO 9001：2015 REACH 5-BENZENETETRAMINE TETRAHYDROCHLORIDE Y15 tetrahydrochloride 1,2,4,5-TETRAAMINOBENZENE TETRAHYDROCHLORIDE 1,2,4,5-Benzenetetraamine tetrahydrochloride FAK Inhibitor 14 Benzene-1,2,4,5-tetraamine tetrahydrochloride Y15 benzene-1,2,4,5-tetraamine hydrochloride 1,2,4,5-Benzenetetramine tetrahydrochloride (Y15), 97% 1,2,4,5-phenylenetetramine tetrahydrochloride 1,2,4, 5-phenyltetramine tetramine hydrochloride 4506-66-5 C6H14Cl4N4 C6H2NH244HCl C6H10N44HCl C6H14N44Cl C6H10N44ClH Organic Building Blocks Nitrogen Compounds Building Blocks Amine Salts Selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI.