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CYCLO(-LEU-PRO)

CYCLO(-LEU-PRO) Structure
CAS No.
2873-36-1
Chemical Name:
CYCLO(-LEU-PRO)
Synonyms
gancidinw;Maculosin 6;Cyclo(Pro-Leu);CYCLO(-LEU-PRO);cyclo-l-leu-l-pro;Cyclo(L-Pro-D-Leu);Cyclo(L-Pro-L-Leu-);Cyclo(proline-leucine);Cyclo-L-prolyl-L-leucine;L-Leucyl-L-prolyl lactaM
CBNumber:
CB4142038
Molecular Formula:
C11H18N2O2
Molecular Weight:
210.27
MOL File:
2873-36-1.mol
MSDS File:
SDS
Modify Date:
2023/5/18 11:31:20
Request For Quotation

CYCLO(-LEU-PRO) Properties

Melting point 163-165℃
Boiling point 427.6±34.0 °C(Predicted)
Density 1.14
storage temp. Inert atmosphere,2-8°C
solubility Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form Solid
pka 13.27±0.40(Predicted)
color White to Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H317
Precautionary statements  P280
Toxicity mouse,LD50,intravenous,80mg/kg (80mg/kg),"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 2, Pg. 1354, 1978.

CYCLO(-LEU-PRO) Chemical Properties,Uses,Production

Description

Cyclo(L-Leu-L-Pro) is a diketopiperazine metabolite that has been isolated from various bacterial and fungal species including Streptomyces. It is active against twelve strains of vancomycin-resistant enterococci (VRE) with MIC values of 12.5 μg/ml for E. faecalis strains K-99-34, K-00-184, and K-00-221. It also inhibits growth of K562, HL-60, and U937 leukemia cells in a concentration-dependent manner when used at concentrations of 1-500 μg/ml. Cyclo(L-Leu-L-Pro) also has antifouling activity, inhibiting attachment of B. amphitrite larva with an EC50 value of 0.15 mM.

Chemical Properties

White Solid

Uses

Sorbicillin analog. A bioactive secondary metabolites from terrestrial Streptomyces species TN262.

Definition

ChEBI: A homodetic cyclic peptide composed from leucyl and prolyl residues.

CYCLO(-LEU-PRO) Preparation Products And Raw materials

Raw materials

Preparation Products

CYCLO(-LEU-PRO) Suppliers

Global( 87)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29897 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
Finetech Industry Limited +86-27-87465837 +8618971612321 China 9624 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
Nextpeptide Inc +86-0571-81612335 +8613336028439 China 19915 58 Inquiry
changzhou huayang technology co., ltd +8615250961469 China 9827 58 Inquiry
Supplier Advantage
A.J Chemicals 58
CLEARSYNTH LABS LTD. 58
career henan chemical co 58
BOC Sciences 58
Chongqing Chemdad Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
Finetech Industry Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
Nextpeptide Inc 58
changzhou huayang technology co., ltd 58

2873-36-1(CYCLO(-LEU-PRO))Related Search:

gypsetin Pyrrolo[1,2-a]pyrazine, octahydro-3-isobutyl- (5CI) CYCLO(-GLY-PRO) (R)-HEXAHYDROPYRROLO[1,2-A]PYRAZIN-1(2H)-ONE HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE
(+/-)-1,4-DIAZABICYCLO[4.4.0]DECANE CYCLO(-LEU-GLY) hexahydropyrrolo[1,2-a]pyrazin-4(1H)-one VERRUCULOGEN amauromine
(S)-1,4-DIAZABICYCLO[4.3.0]NONANE 3-ISOBUTYL-6-METHYL-2,5-PIPERAZINEDIONE CYCLO(-LEU-PRO)
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2-a)pyrazine-1,4-dione,hexahydro-3-isobutyl-pyrrolo(stereoisomer 4-dione,hexahydro-3-(2-methylpropyl)-2-a)pyrazine-(3s-trans)-pyrrolo( cyclo-l-leu-l-pro gancidinw (3S-trans)-hexahydro-3-isobutylpyrrolo[1,2-a]pyrazine-1,4-dione (3S,8aS)-2,3,6,7,8,8a-Hexahydro-3-(2-methylpropyl)pyrrolo[1,2-a]pyrazine-1,4-dione (3S,8aS)-Octahydro-3-(2-methylpropyl)pyrrolo[1,2-a]pyrazine-1,4-dione Cyclo(L-leucyl-L-prolyl-) CYCLO(-LEU-PRO) Cyclo(L-Pro-L-Leu-) 3-(2-methylpropyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione 3-isobutyl-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-quinone (3S-trans)-Hexahydro-3-(2-Methylpropyl)-pyrrolo[1,2-a]pyrazine-1,4-dione Cyclo(L-Pro-D-Leu) Cyclo(Pro-Leu) Cyclo(proline-leucine) Cyclo-L-prolyl-L-leucine L-Leucyl-L-proline lactaM L-Leucyl-L-prolyl lactaM Maculosin 6 (3S,8aS)-3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(2-methylpropyl)-, (3S,8aS)- Cyclo(-L-Leu-L-Pro)≥ 99% (TLC) 3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione Cyclo(L-prolyl-L-leucyl) 2873-36-1