ChemicalBook > Product Catalog >API >Circulatory system drugs >Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate

CAS No.: 144689-93-0

Chemical Name:: Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate

Synonyms: 4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-1H-IMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER;ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-iMidazole-5-carboxylate;ETHYL-4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-IMIDAZOLE-5-CARBOXYLATE;Olmesartan intermediate;4-(1-Hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylic acid;5-(1-HYDROXYL-1-METHYLETHYL)-2-PROPYL-IMIDAZOL-4-YLCARBOXYLIC ACID ETHYL ESTER;1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-, ethyl ester;OMSTint-D;)-2-propyL;Olmesartan Impurity 2

CBNumber:: CB4151009

Molecular Formula:: C12H20N2O3

Molecular Weight:: 240.3

MOL File:: 144689-93-0.mol

MSDS File:: SDS

Modify Date:: 2024/6/15 22:11:33

Request For Quotation

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate Properties

Melting point	98-100°C
Boiling point	456.2±35.0 °C(Predicted)
Density	1.131±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	Chloroform, Ethyl Acetate, Methanol
form	Solid
pka	11.61±0.10(Predicted)
color	Pale Yellow
InChI	InChI=1S/C12H20N2O3/c1-5-7-8-13-9(11(15)17-6-2)10(14-8)12(3,4)16/h16H,5-7H2,1-4H3,(H,13,14)
InChIKey	KZBJJAFGNMRRHN-UHFFFAOYSA-N
SMILES	C1(CCC)NC(C(OCC)=O)=C(C(O)(C)C)N=1
CAS DataBase Reference	144689-93-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
HS Code	2933.29.9000

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Solid

Application

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate is a synthetic drug with pharmacological properties that are similar to those of the natural product medoxomil. It has been shown to be a potent blocker of the GABA receptor and is used for the treatment of epilepsy.It has been shown to be an inhibitor of rat liver microsomes and also has a high affinity for the enzyme cilexetil, which is responsible for the conversion of cilexetil into its active form.

Synthesis

To a solution of MeMgCl(55.86 g, 0.74 mol) in tetrahydrofuran was added a solution of diethyl 2-propyl imidazole- 4,5-dicarboxylate (50 g,0.19 mol) in tetrahydrofuran (200 ml) at -10 to 0°C under N2 atmosphere. The mixture was stirred at -5 to 0°C for 10 minutes. The reaction mass was quenched into 400 ml 25 % ammonium chloride solution, followed by extraction with ethyl acetate (300 ml). The organic phase was separated, washed with brine, dried over Na2SO4, and concentrated in vacuo to give Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate, which was crystallized using diisopropyl ether. Yield: 85-90 %.

Definition

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate is a crucial intermediate for the synthesis of olmesartan medoxomil, which can be produced via the reaction of diethyl 2-propyl-imidazole-4,5-dicarboxylate, the raw material, with methylmagnesium bromide, followed by the acidification with saturated ammonium chloride solution.

Hazard

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate is sensitive to the skin and may cause allergic skin reactions. It is irritating to the skin and eyes and may also cause respiratory irritation. It is poisonous to aquatic organisms.

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

Olmesartan Medoxomil Trityl olmesartan Trityl Olmesartan Medoxomil 1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-, ethyl ester

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate Suppliers

Global( 510)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
GLR Innovations	+91 9891111994	New Delhi, India	4542	58	Inquiry
VASISTA LIFE SCIENCES PRIVATE LIMITED	+91-04029554774 +91-9010855544	Hyderabad, India	153	58	Inquiry
BNR LABORATORIES	+91-9490673489 +91-9490673489	Telangana, India	25	58	Inquiry
SGMR PHARMACEUTICALS PVT LTD	+91-9032001889 +91-9032001889	Telangana, India	83	58	Inquiry
GSV speciality chemicals	+91-91823634932 +91-91823634932	Hyderabad, India	127	58	Inquiry
PRASANNA BIO MOLECULES PVT LTD	9666900855	Telangana, India	15	58	Inquiry
SRINIVASA LABS	+91-8247888505 +91-8247888505	Hyderabad, India	76	58	Inquiry
Sadasivarao g	+91 9515157878	Hyderabad, India	107	58	Inquiry
Ganapa Liife Science	+91 7760536535	Bangalore, India	168	58	Inquiry
RESONANCE LABS	+91-8027630180 +91-8027630180	Karnataka, India	32	58	Inquiry

Supplier	Advantage
GLR Innovations	58
VASISTA LIFE SCIENCES PRIVATE LIMITED	58
BNR LABORATORIES	58
SGMR PHARMACEUTICALS PVT LTD	58
GSV speciality chemicals	58
PRASANNA BIO MOLECULES PVT LTD	58
SRINIVASA LABS	58
Sadasivarao g	58
Ganapa Liife Science	58
RESONANCE LABS	58

144689-93-0(Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate)Related Search:

Olmesartan Calcitonin salmon Olmesartan 4-(1-Methoxy-1-methylethyl)-2-propyl-1H-Imidazole-5-carboxylic acid ethyl ester OlMesartan Methyl Ester

5-[4’-Hydroxymethyl-(1,1’-biphenyl)-2-yl]-1-triphenylmethyltetrazole 4-Cloromethyl-5-methyl-1,3-dioxol-2-one 2,2'-(2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-4,5-diyl)bis(propan-2-ol) 3,6-Dihydro-6,6-diMethyl-2-propyl-3-[[2'-[2-(triphenylMethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-4H-furo[3,4-d]iMidazol-4-one OlMesartan MedoxoMil iMpurity V

N-Trityl Olmesartan Ethyl Ester Diethyl 2-propylImidazoledicarbonate OlMesartan MedoxoMil Butyl IMpurity Olmesartan Impurity 12 5-[4'-(Bromomethyl)-[1,1'-biphenyl]-2-yl]-2-(triphenylmethyl)-2H-tetrazole

4,5-Dimethyl-1,3-dioxol-2-one 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid Olmesartan Impurity 10

chevron_left

1of4

chevron_right

1H-Imidazole-4-carboxylicacid,5-(1-hydroxy-1-met 1H-Imidazole-5-carboxylicacid,4-(1-hydroxy-1-met 1H-Imidazole-4-carboxylic acid,5-(1-hydroxy-1-methylethyl)-2- propyl-,ethyl ester 4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-1H-IMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER 98+% 5-(1-hydroxy-1-methylethyl)-2-propyl-,ethyl ester 4-(1-Hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylic acid ethyl ester 4-(1-Hydroxy-1-methylethyl)-2-propyl- 5-(1-hydroxy-1-Methylethyl)-2-propyl-1H-IMidazole- 4-carboxylic acid ethyl ester 1H-Imidazole-4-carboxylic acid, 5-(1-hydroxy-1-methylethyl)-2-propyl-, ethyl ester (9CI) 5-(1-Hydroxy-1-Methyl-ethyl)-2-propyl-3H-iMidazole-4-carboxylic acid ethyl ester Ethyl 4-(2-Hydroxy-2-propyl)-2-propyl-1H-iMidazole-5-carboxylate OlMesartan IMidazole Ethyl Ester IMpurity 1h-iMdazole-4-carboxylic acid, 5-(1-hydroxy-1-Methylethyl)-2-propyl-,ethyl ester 1H-IMIDAZOLE-4-CARBOXYLIC ACID-5-(1-HYDROXY-1-METHYETHYL)-2-PROPYL-ETHYL ESTER OlMesartan IMpurity (Ethyl 4-(1-Hydroxy-1-Methylethyl)-2- Propyl-IMidazole-5-Carboxylate) 4-(2-Hydroxypropan-2-yl)-2-propyl-1H-iMidazole-5-carboxylic acid ethyl ester (EPIC) Ethyl 4-(1-hydroxy-1-Methylethyl)-2-propyliM... Ethyl 4-(2-Hydroxy-2-propyl)-2-propyl-1H-imidazole-5-carboxylate 4-(1-Hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylic acid ethyl ester (OM-7) 4-(1-Hydroxy-isopropyl)-2-propyl-1H-imidazol-5-carboxylic acid ethyl ester Olmesartan Medoxomil Impurity 33 Olmesartan Medoxomil-18 OMSTint-D ethyl 5-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-4-carboxylate Olmesartan Impurity 2 Olmesartan Impurity 50 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate Ethyl4-(2-Hydroxy-2-propyl)-2-propyl-1H-imidazole-5-carboxylate> 4-(1-hydroxy-1-methyL 4-(1-Hydroxy-1-methylethyl)-2-Propyl-1H-Imiidazole 5-Carboxylic acid ethyl ester )-2-propyL 4-(2-hydroxy-2-propyl) -2-propyl-1H-imidazole-5-formate, ethyl ester 4-(2-Hydroxy-2-propyl)-2-propyl-1H-imidazole-5-carboxylic Acid Ethyl Ester Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate USP/EP/BP 4-(1-hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylic acid ethyl ester for olmesartan 4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-1H-IMIDAZOLE-5-CARBOXYL IC ACID ETHYL ESTEROLE Imidazole-5-carboxylic ethyl ester [5-(1-Hydroxyl-1-methylethyl)-2-propyl-imidazol-4-yl]carboxy... Azilsartan medoxomil impurity230 4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-1H-IMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER ETHYL-4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-IMIDAZOLE-5-CARBOXYLATE Olmesartan intermediate 5-(1-HYDROXYL-1-METHYLETHYL)-2-PROPYL-IMIDAZOL-4-YLCARBOXYLIC ACID ETHYL ESTER 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-, ethyl ester ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-iMidazole-5-carboxylate 4-(1-Hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylic acid Ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate (Olmesartan Impurity) 4-(1-hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxyhio acid ethyl ester (1-Hydroxyl-1-methylethyl)-2-propyl-imidazol-4- yl]carboxylic acid ethyl ester Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carbo Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1H-imidazol-5-carboxylate Ethyl 5-(1-Hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4-carboxylate Olmesartan ester impurity 27 Ethy-4-(1-Hydroxy-1-Mmethylethyl)-2-propylImidazole-5-Carboxylate. Ethyl5-(1-Hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4- carboxylate (Imidazole Ester) Olmesartan Imidazole Ethyl Ester Impurity Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5- carboxylate OLM intermediate (4-(1-Hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylic acid ethyl ester) 4-(1-hydroxy-1-methylethyl)-2-propyl-1H-Imidazole