DGAT-1 inhibitor
- CAS No.
- 959122-11-3
- Chemical Name:
- DGAT-1 inhibitor
- Synonyms
- CS-121;A922500;DGAT-1 inhibitor;DGAT-1 Inhibitor 4a;DGAT-1 Inhibitor, A 922500;DGAT-1 inhibitor USP/EP/BP;A922500(DGAT-1 Inhibitor 4a);DGAT-1 Inhibitor A922500 A-922500;DGAT-1 INHIBITOR 4A; A-922500; A922500;Diacyl glycerolacyltransferase 1 inhibitor
- CBNumber:
- CB42470944
- Molecular Formula:
- C26H24N2O4
- Molecular Weight:
- 428.48
- MOL File:
- 959122-11-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:01:58
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06, GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H319-H410 | |||||||||
| Precautionary statements | P273-P301+P310-P305+P351+P338-P501 | |||||||||
| Hazard Codes | T,N | |||||||||
| Risk Statements | 25-36-50 | |||||||||
| Safety Statements | 26-45-61 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
DGAT-1 inhibitor price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A1737 | A922500 | 959122-11-3 | 1MG | ₹5477.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A1737 | A922500 | 959122-11-3 | 5MG | ₹22364.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A1737 | A922500 | 959122-11-3 | 10MG | ₹38872.58 | 2022-06-14 | Buy |
DGAT-1 inhibitor Chemical Properties,Uses,Production
Uses
A922500 has been used in the inhibition of diacylglycerol acyltransferase (DGAT) in epithelial human breast cancer cell line (MDA-MB-231), digitonin-permeabilized human cancer cells, human myotubes and macrophages.
Biological Activity
Diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC 50 values are 7 and 24 nM at human and mouse DGAT-1 respectively) that is devoid of activity at DGAT-2, ACAT1 or ACAT2. Induces significant weight loss without altering food intake, and decreases liver and plasma triglyceride levels in vivo . Orally active.
Biochem/physiol Actions
The diacylglycerol acyltransferase (DGAT) 1 inhibitor A922500 was shown to effectively reduce postprandial serum triglyceride levels in rodents at concentrations of 0.03, 0.3 and 3 mg/kg. These results suggest A922500 may have beneficial effects in reducing the risk of cardiovascular disease.
DGAT-1 inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32835 | 60 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49403 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29820 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 23430 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Suzhou Victorypharm Co.,Ltd. | +86-13916956214 | China | 1301 | 58 | Inquiry |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | China | 3136 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |