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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >PI3K / Akt / mTOR >mTOR inhibitors >OSI-027

OSI-027

OSI-027 Structure
CAS No.
936890-98-1
Chemical Name:
OSI-027
Synonyms
CS-436;OSI-027;ASP4786;CPD2801;OSI-027, >=98%;OSI027;OSI 027;OSI-027 USP/EP/BP;OSI-027, 10 mM in DMSO;OSI-027;OSI 027;ASP4786;trans-4-[4-Amino-5-(7-methoxy-1H-i
CBNumber:
CB42538725
Molecular Formula:
C21H22N6O3
Molecular Weight:
406.44
MOL File:
936890-98-1.mol
Modify Date:
2025/4/17 18:22:24
Request For Quotation

OSI-027 Properties

Melting point >149°C (subl.)
Density 1.59
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly)
pka 4.44±0.10(Predicted)
form Solid
color Pale Beige to Light Beige

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
NFPA 704
0
2 0

OSI-027 Chemical Properties,Uses,Production

Description

The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that is central to two protein complexes, mTORC1 and mTORC2. These complexes are differentially regulated (e.g., only mTORC1 is sensitive to rapamycin ) and regulate different pathways. OSI-027 is an inhibitor of the catalytic site of mTOR and, as a result, inhibits both mTORC1 and mTORC2 (IC50s = 22 and 65 nM, respectively). It is selective for mTOR over phosphatidylinositol 3-kinase isoforms and DNA protein kinase. OSI-027 prohibits proliferation, induces autophagy, and potentiates apoptosis in BCR-ABL transformed cells and other cancer cells at 10 μM. OSI-027 is effective in vivo, blocking the phosphorylation of targets of mTORC1 and mTORC2 and suppressing tumor growth in several different human xenograft models.

Uses

OSI-027 is a kinase inhibitor with anti-tumor activity, used in treatment of breast cancer.

OSI-027 Preparation Products And Raw materials

Raw materials

Preparation Products

OSI-027 Suppliers

Global( 132)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29858 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49732 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32222 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 22855 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10473 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6391 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24727 58 Inquiry
Nantong HI-FUTURE Biology Co., Ltd. +undefined18051384581 China 3135 58 Inquiry
TargetMol Chemicals Inc. United States 38641 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
career henan chemical co 58
CONIER CHEM AND PHARMA LIMITED 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
LEAP CHEM CO., LTD. 58
Nantong HI-FUTURE Biology Co., Ltd. 58
TargetMol Chemicals Inc. 58

OSI-027 Spectrum

OSI-027(936890-98-1)1HNMR

936890-98-1(OSI-027)Related Search:

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OSI-027 trans-4-[4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl]cyclohexanecarboxylic acid 4-(4-aMino-5-(7-Methoxy-1H-indol-2-yl)-1,2-dihydroiMidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid hydrochloride 4-(4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f] [1,2,4]Triazin-7-yl)cyclohexanecarboxylic Acid (1r,4r)-4-(4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[1,5-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid ASP4786 OSI-027 trans-4-[4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl]cyclohexanecarboxylic acid trans-4-[4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl]cyclohexanecarboxylic acid OSI-027 OSI-027, >=98% CYCLOHEXANECARBOXYLIC ACID, 4-[4-AMINO-5-(7-METHOXY-1H-INDOL-2-YL)IMIDAZO[5,1-F][1,2,4]TRIAZIN-7-YL]-, TRANS- trans-4-[4-Amino-5-(7-methoxy-1H-i (1r,4r)-4-(4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo-[5,1-f][1,2,4]triazin-7-yl)cyclohexaneca OSI-027;OSI 027;ASP4786 CS-436 CPD2801 OSI027;OSI 027 OSI-027 USP/EP/BP OSI-027 (ASP-4786, CERC-006, AEVI-006) OSI-027, 10 mM in DMSO 936890-98-1 Akt mTOR PI3K Inhibitors