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KRN 633

CAS No.: 286370-15-8

Chemical Name:: KRN 633

Synonyms: CS-463;KRN 633;KRN 633;KRN-633;KRN 633 USP/EP/BP;KRN633; KRN-633; KRN 633;VEGFR Tyrosine Kinase Inhibitor III, KRN633;KRN 633 (This product is unavailable in the U.S.);1-(2-chloro-4-(6,7-diMethoxyquinazolin-4-yloxy)phenyl)-3-propylurea;N-[2-Chloro-4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl]-N'-propylurea;N-[2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propylurea

CBNumber:: CB42561482

Molecular Formula:: C20H21ClN4O4

Molecular Weight:: 416.86

MOL File:: 286370-15-8.mol

MSDS File:: SDS

Modify Date:: 2023/9/4 15:51:00

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KRN 633 Properties

Melting point	231-232°C
Boiling point	545.6±50.0 °C(Predicted)
Density	1.321
storage temp.	-20°C
solubility	DMSO: soluble3mg/mL, clear (warmed)
pka	13.08±0.70(Predicted)
form	powder
color	white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P280-P305+P351+P338

Hazard Codes

Risk Statements

WGK Germany

NFPA 704

	0
2		0

KRN 633 Chemical Properties,Uses,Production

Uses

KRN 633 is an ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 170 nM/160 nM/125 nM and also inhibits PDGFRα/β with IC50 of 965 nM/9850 nM.

Biochem/physiol Actions

KRN633 is a cell-permeable; reversible and ATP-competitive inhibitor of vascular endothelial growth factor receptor tyrosine kinase (VEGFR) with IC50 values of 170, 160, and 125 nM for VEGFR-1, -2, -3, respectively. Krn633 inhibits PDGFR-α and c-Kit only at higher concentrations (IC50 = 0.97 and 4.33 μM, respectively) and is inactive towards a panel of 17 other kinases (IC50 >/= 10 μM).

KRN 633 Preparation Products And Raw materials

Raw materials

Preparation Products

KRN 633 Suppliers

Global( 117)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29898	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	24639	58	Inquiry
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	China	52861	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
changzhou huayang technology co., ltd	+8615250961469	China	9827	58	Inquiry

Supplier	Advantage
TCI Chemicals (India) Pvt. Ltd.	58
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
Dideu Industries Group Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58
changzhou huayang technology co., ltd	58

KRN 633 Spectrum

KRN 633(286370-15-8)MS KRN 633(286370-15-8)¹HNMR

286370-15-8(KRN 633)Related Search:

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KRN 633 N-[2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propylurea 1-(2-chloro-4-(6,7-diMethoxyquinazolin-4-yloxy)phenyl)-3-propylurea N-[2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propylurea KRN633 VEGFR Tyrosine Kinase Inhibitor III, KRN633 KRN 633;KRN-633 CS-463 KRN633; KRN-633; KRN 633 Urea, N-[2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propyl- KRN 633 (This product is unavailable in the U.S.) KRN 633 USP/EP/BP N-[2-Chloro-4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl]-N'-propylurea 286370-15-8 Inhibitors