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KRN 633

KRN 633 Structure
CAS No.
286370-15-8
Chemical Name:
KRN 633
Synonyms
CS-463;KRN 633;KRN 633;KRN-633;KRN 633 USP/EP/BP;KRN-633, 10 mM in DMSO;KRN633; KRN-633; KRN 633;VEGFR Tyrosine Kinase Inhibitor III, KRN633;KRN 633 (This product is unavailable in the U.S.);1-(2-chloro-4-(6,7-diMethoxyquinazolin-4-yloxy)phenyl)-3-propylurea;N-[2-Chloro-4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl]-N'-propylurea
CBNumber:
CB42561482
Molecular Formula:
C20H21ClN4O4
Molecular Weight:
416.86
MOL File:
286370-15-8.mol
MSDS File:
SDS
Modify Date:
2025/4/17 18:22:24
Request For Quotation

KRN 633 Properties

Melting point 231-232°C
Boiling point 545.6±50.0 °C(Predicted)
Density 1.321
storage temp. -20°C
solubility DMSO: soluble3mg/mL, clear (warmed)
pka 13.08±0.70(Predicted)
form powder
color white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
NFPA 704
0
2 0

KRN 633 Chemical Properties,Uses,Production

Uses

KRN 633 is an ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 170 nM/160 nM/125 nM and also inhibits PDGFRα/β with IC50 of 965 nM/9850 nM.

Biochem/physiol Actions

KRN633 is a cell-permeable; reversible and ATP-competitive inhibitor of vascular endothelial growth factor receptor tyrosine kinase (VEGFR) with IC50 values of 170, 160, and 125 nM for VEGFR-1, -2, -3, respectively. Krn633 inhibits PDGFR-α and c-Kit only at higher concentrations (IC50 = 0.97 and 4.33 μM, respectively) and is inactive towards a panel of 17 other kinases (IC50 >/= 10 μM).

KRN 633 Preparation Products And Raw materials

Raw materials

Preparation Products

KRN 633 Suppliers

Global( 124)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6768 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6100 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 33024 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29858 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32159 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 22854 58 Inquiry
Dayang Chem (Hangzhou) Co.,Ltd. +86-0571-88938639 +8617705817739 China 52849 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10473 58 Inquiry
Henan Alfa Chemical Co., Ltd +8615838112936 China 13194 58 Inquiry
Supplier Advantage
TCI Chemicals (India) Pvt. Ltd. 58
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Dayang Chem (Hangzhou) Co.,Ltd. 58
Zhejiang J&C Biological Technology Co.,Limited 58
Henan Alfa Chemical Co., Ltd 58

KRN 633 Spectrum

KRN 633(286370-15-8)MSKRN 633(286370-15-8)1HNMR

286370-15-8(KRN 633)Related Search:

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KRN 633 N-[2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propylurea 1-(2-chloro-4-(6,7-diMethoxyquinazolin-4-yloxy)phenyl)-3-propylurea N-[2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propylurea KRN633 VEGFR Tyrosine Kinase Inhibitor III, KRN633 KRN 633;KRN-633 CS-463 KRN633; KRN-633; KRN 633 Urea, N-[2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propyl- KRN 633 (This product is unavailable in the U.S.) KRN 633 USP/EP/BP N-[2-Chloro-4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl]-N'-propylurea KRN-633, 10 mM in DMSO 286370-15-8 Inhibitors