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SU 11274

SU 11274 Structure
CAS No.
658084-23-2
Chemical Name:
SU 11274
Synonyms
1H-Indole-5-sulfonamide, N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-, (3Z)-;Sul1274;PKI-SU11274;SU 11274, >=98%;SU 11274，SU 11274;SU 11274 USP/EP/BP;SU11274(PKI-SU11274);Met Kinase Inhibitor;SU-11274;PKI-SU11274;SU 11274;Met Kinase Inhibitor SU11274 SU-11274
CBNumber:
CB3504776
Molecular Formula:
C28H30ClN5O4S
Molecular Weight:
568.09
MOL File:
658084-23-2.mol
MSDS File:
SDS
Modify Date:
2023/6/8 9:02:14
Request For Quotation

SU 11274 Properties

Density 1.401±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 10 mg/mL at 60 °C
pka 11.62±0.20(Predicted)
form powder
color orange
InChIKey FPYJSJDOHRDAMT-KQWNVCNZSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H335-H315-H319
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
NFPA 704
0
2 0

SU 11274 price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) S9820 SU 11274 ≥98% (HPLC), powder 658084-23-2 25MG ₹88981.5 2022-06-14 Buy
Sigma-Aldrich(India) 448101 Met Kinase Inhibitor - CAS 658084-23-2 - Calbiochem The Met Kinase Inhibitor, also referenced under CAS 658084-23-2, controls the biological activity of Met Kinase. This small molecule/inhibitor is prim 658084-23-2 1MG ₹13100 2022-06-14 Buy
Product number Packaging Price Buy
S9820 25MG ₹88981.5 Buy
448101 1MG ₹13100 Buy

SU 11274 Chemical Properties,Uses,Production

Description

MET is a proto-oncogene which encodes the hepatocyte growth factor receptor c-Met. It has normal roles in morphogenesis, migration, apoptosis, and angiogenesis. Dysregulation of c-Met occurs in many types of cancer. SU11274 is a potent, selective, ATP-competitive inhibitor of c-Met (IC50 = 20 nM). It has much less or no activity against other receptor tyrosine kinases. SU11274 induces apoptosis and cell cycle arrest in transformed Ba/F3 cells and cancer cell lines.

Uses

SU 11274 is a competitive inhibitor of Met kinase activity.

Biochem/physiol Actions

SU 11274 is a class I c-Met inhibitor that competes with ATP to bind to the activation loop of c-Met.1 Inhibition of c-Met by SU 11274 is effective in improving the clinical outcome in non-small cell lung cancer cell lines.2

SU 11274 Preparation Products And Raw materials

Raw materials

Preparation Products

SU 11274 Suppliers

Global( 123)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26165 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Nantong HI-FUTURE Biology Co., Ltd. +undefined18051384581 China 3136 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
GIHI CHEMICALS CO.,LIMITED +8618058761490 China 49999 58 Inquiry
Supplier Advantage
Capot Chemical Co.,Ltd. 60
ATK CHEMICAL COMPANY LIMITED 60
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
Nantong HI-FUTURE Biology Co., Ltd. 58
TargetMol Chemicals Inc. 58
GIHI CHEMICALS CO.,LIMITED 58

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PKI-SU11274 N-(3-Chlorophenyl)-N-methyl-3-[[3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl]methylene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide N-(3-Chlorophenyl)-N-methyl-3-[[3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl]methylene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide SU11274 SU 11274, >=98% Met Kinase Inhibitor (Z)-N-(3-Chlorophenyl)-3-((3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl)methy (3z)-n-(3-chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1h-pyrrol-2-yl}methylene)-n-methyl-2-oxo-2,3-dihydro-1h-indole-5-sulfonamide SU 11274，SU 11274 (Z)-N-(3-chlorophenyl)-3-((3,5-diMethyl-4-(4-Methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl)Methylene)-N-Methyl-2-oxoindoline-5-sulfonaMide SU11274(PKI-SU11274) Sul1274 (Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-(1-methylpiperazine-4-carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxoindoline-5-sulfonamide (3Z)-N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl]methylidene]-N-methyl-2-oxo-1H-indole-5-sulfonamide (3Z)-N-(3-Chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-sulfonamide Met Kinase Inhibitor - CAS 658084-23-2 - Calbiochem SU-11274;PKI-SU11274;SU 11274 SU 11274 USP/EP/BP 1H-Indole-5-sulfonamide, N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-, (3Z)- Met Kinase Inhibitor SU11274 SU-11274 SU 11274,Inhibitor,Autophagy,inhibit,c-Met/HGFR,Apoptosis,SU-11274,SU11274 658084-23-2 C28H30ClN5O4S C28H30CIN5O4S C28Cl1H30N5O4S1 Inhibitors