SU5402
- CAS No.
- 215543-92-3
- Chemical Name:
- SU5402
- Synonyms
- SU5402;CS-457;CS-1480;PNU-0290908;PF-02969207;SU 5402, >=98%;SU-5402/SU5402;SU5402;SU-5402;SU 5402;SU5402 - CAS 215543-92-3 - Calbiochem;4-chloro-2,3-dihydro-1H-indene-3-carboxylicacid
- CBNumber:
- CB3383083
- Molecular Formula:
- C17H16N2O3
- Molecular Weight:
- 296.32
- MOL File:
- 215543-92-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | >222°C (dec.) |
|---|---|
| Boiling point | 592.6±50.0 °C(Predicted) |
| Density | 1.363±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble10mg/mL (clear solution) |
| pka | 4.60±0.10(Predicted) |
| form | powder |
| color | light orange to dark orange |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| InChIKey | JNDVEAXZWJIOKB-JYRVWZFOSA-N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| WGK Germany | 3 |
SU5402 price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0443 | SU-5402 ≥98% (HPLC) | 215543-92-3 | 5MG | ₹12297.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 572630 | SU5402 - CAS 215543-92-3 - Calbiochem SU5402, CAS 215543-92-3, is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of FGFR1 (IC?? = 10-20 μM in t | 215543-92-3 | 500μG | ₹28660 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0443 | SU-5402 ≥98% (HPLC) | 215543-92-3 | 25MG | ₹50076.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 572630 | SU5402 - CAS 215543-92-3 - Calbiochem SU5402, CAS 215543-92-3, is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of FGFR1 (IC?? = 10-20 μM in t | 215543-92-3 | 1MG | ₹53810.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 572630 | SU5402 - CAS 215543-92-3 - Calbiochem SU5402, CAS 215543-92-3, is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of FGFR1 (IC?? = 10-20 μM in t | 215543-92-3 | 2MG | ₹80730 | 2022-06-14 | Buy |
SU5402 Chemical Properties,Uses,Production
Chemical Properties
Yellow-Green Solid
Uses
SU5402 has been used as a fibroblast growth factor receptor inhibitor:
- in cell signalling experiments to stimulate cells for MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay
- to study its effect on the expression of osteogenic markers and expression of osteoprotegerin and RANKL (runt-related transcription factor(RUNX)-2
- to prepare a stock solution with DMSO (Dimethyl superoxide) for cell culture medium and also to co-treat embryos
- to study its effect on osteogenic markers.
Definition
ChEBI: An oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is substituted by a 3-(2-carboxyethyl)-4-methyl-1H-pyrrol-2-yl group. It is an ATP-competitive inhibitor of the tyrosine kinase activity of fibr blast growth factor receptor 1.
Biological Activity
Potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC 50 values are 0.02, 0.03, 0.51 and > 100 μ M at VEGFR2, FGFR1, PDGFR β and EGFR respectively). Inhibits embryonic left-right determination and exhibits potent anticancer activity in vitro and in vivo .
SU5402 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 136)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9338 | 55 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29900 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | China | 3136 | 58 | Inquiry |
215543-92-3(SU5402)Related Search:
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SU5402
3-[4-METHYL-2-[(2-OXO-1H-INDOL-3-YLIDENE)METHYL]-1H-PYRROL-3-YL]PROPANOIC ACID
3-[3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-METHYLIDENYL]-2-INDOLINONE
2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)Methyl]-4-Methyl-
SU-5402/SU5402
2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid
3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone
3-[4-Methyl-2-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl]-propionic acid
PF-02969207
PNU-0290908
SU 5402, >=98%
2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid
SU5402 - CAS 215543-92-3 - Calbiochem
CS-1480
CS-457
SU5402;SU-5402;SU 5402
1H-Pyrrole-3-propanoic acid, 2-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-
4-chloro-2,3-dihydro-1H-indene-3-carboxylicacid
Carbamicacid,N-3-cyclohexen-1-yl-,1,2-dimethylethylester
3-(4-methyl-2-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid
215543-92-3
Angiogenesis and Metastasis
Heterocycles
Inhibitors
Intermediates & Fine Chemicals
Pharmaceuticals