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Ko 143

Ko 143 Structure
CAS No.
461054-93-3
Chemical Name:
Ko 143
Synonyms
Ko 143;12aS)-;4-dioxo-;6]pyrido[3;Ko143 ,99%;Pyrazino[1';Ko143 hydrate;KO 143;KO-143;KO143;4-b]indole-3-propanoicacid;12a-octahydro-9-Methoxy-6-(2-Methylpropyl)-1
CBNumber:
CB81562442
Molecular Formula:
C26H35N3O5
Molecular Weight:
469.57
MOL File:
461054-93-3.mol
MSDS File:
SDS
Modify Date:
2024/11/16 15:32:52
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Ko 143 Properties

Melting point 147 ºC
Boiling point 689.8±55.0 °C(Predicted)
Density 1.24
storage temp. Desiccate at -20°C
solubility DMSO: >10mg/mL
form powder
pka 13.31±0.60(Predicted)
color white to off-white
Stability Stable for 2 years from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
NFPA 704
0
2 0

Ko 143 price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) K2144 Ko143 hydrate ≥98% (HPLC) 461054-93-3 1MG ₹12697.73 2022-06-14 Buy
Sigma-Aldrich(India) K2144 Ko143 hydrate ≥98% (HPLC) 461054-93-3 5MG ₹50379.55 2022-06-14 Buy
Product number Packaging Price Buy
K2144 1MG ₹12697.73 Buy
K2144 5MG ₹50379.55 Buy

Ko 143 Chemical Properties,Uses,Production

Description

Breast cancer resistance protein (BCRP) is an ATP-binding cassette protein known also as ABCG2. While it normally functions as a high-capacity urate exporter in the renal system, it also acts as a xenobiotic transporter and contributes to multidrug resistance (e.g., to mitoxantrone) in certain types of cancer. BCRP is abundant at the intestinal epithelium and blood-brain barrier, potentially restricting the distribution of certain drugs. Ko 143 is a potent and selective inhibitor of BCRP, preventing the export of mitoxantrone and topotecan in breast cancer cell lines (EC50s = 23 and 26 nM, respectively). It is much less effective at the transporters P-glycoprotein and multidrug resistance-associated protein 1, MRP1. Ko 143 is effective in vivo in mice.

Uses

A potent BCRP (breast cancer resistance protein) inhibitor

Biological Activity

Potent and selective breast cancer resistance protein multidrug transporter (BCRP) inhibitor (EC 90 = 26 nM). Displays > 200-fold selectivity over P-gp and MRP-1 transporters. Increases intracellular drug accumulation and reverses BCRP-mediated multidrug resistance.

Ko 143 Preparation Products And Raw materials

Raw materials

Preparation Products

Ko 143 Suppliers

Global( 98)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39894 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49374 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29811 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10473 58 Inquiry
TargetMol Chemicals Inc. United States 38470 58 Inquiry
HangZhou RunYan Pharma Technology Co.,LTD. +8618882027439 China 302 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57505 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131957 58 Inquiry
Shanghai Zeye Biotechnology Co., Ltd. 021-61998551 13122364865 China 9772 58 Inquiry
Jiangxi Jianglan Pure Biological Reagent Co., Ltd. 021-54720761 CHINA 6134 58 Inquiry
Supplier Advantage
Chongqing Chemdad Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
career henan chemical co 58
Zhejiang J&C Biological Technology Co.,Limited 58
TargetMol Chemicals Inc. 58
HangZhou RunYan Pharma Technology Co.,LTD. 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58
Shanghai Zeye Biotechnology Co., Ltd. 58
Jiangxi Jianglan Pure Biological Reagent Co., Ltd. 58

Ko 143 Spectrum

Ko 143(461054-93-3)1HNMR

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Pyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid, 1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxo-, 1,1-dimethylethyl ester, (3S,6S,12aS)-(Ko143) Ko 143 (3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester 12a-octahydro-9-Methoxy-6-(2-Methylpropyl)-1 12aS)- 4-b]indole-3-propanoicacid 4-dioxo- 6]pyrido[3 Pyrazino[1' Ko143 ,99% Ko143 hydrate tert-Butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7, 12,12a-octahydropyrazino[1 (3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-( 2-methylpropyl)-1,4-dioxopyrazino[1′,2′:1,6]pyrido[3,4- b]indole-3-propanoic acid 1,1-dimethylethyl ester hydrate tert-butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)propanoate KO 143;KO-143;KO143 tert-Butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino (3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2' 1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester (3s,6s,12as)-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester tert-Butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)propanoate (3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-( 2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4- b]indole-3-propanoic Acid tert-Butyl Ester 461054-93-3 C26H35N3O5 C26H36N3O5 Pharmaceuticals Chiral Reagents Heterocycles Inhibitors Intermediates & Fine Chemicals