SU 4312
- CAS No.
- 5812-07-7
- Chemical Name:
- SU 4312
- Synonyms
- SU 4312;NSC 86429;SU4312(NSC86429);SU 4312;NSC 86429;SU-4312;NSC-86429;3-(4-DIMETHYLAMINOBENZYLIDENYL)-2-INDOLINONE;(Z)-3-(4-(DIMETHYLAMINO)BENZYLIDENE)INDOLIN-2-ONE;3-[[(4-DIMETHYLAMINO)PHENYL]METHYLENE]-1,3-DIHYDRO-2H-INDOL-2-ONE;2H-Indol-2-one, 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro;3-[[(4-Dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one, E/Z mixture;PDGFR,Inhibitor,SU4312,VEGFR,inhibit,Vascular endothelial growth factor receptor,Platelet-derived growth factor receptor,SU-4312
- CBNumber:
- CB0444460
- Molecular Formula:
- C17H16N2O
- Molecular Weight:
- 264.32
- MOL File:
- 5812-07-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:02:46
| Melting point | 225-232 °C |
|---|---|
| Boiling point | 497.1±45.0 °C(Predicted) |
| Density | 1.219±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 30 mg/mL |
| form | Orange solid. |
| pka | 12.89±0.20(Predicted) |
| color | orange |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
SU 4312 Chemical Properties,Uses,Production
Uses
SU 4312 is a vascular endothelial growth factor receptor KDR tyrosine kinase antagonist.
Definition
ChEBI: A member of the class of oxindoles that is 3-methyleneoxindole in which one of the hydrogens of the methylene group has been replaced by a p-(dimethylamino)phenyl group. SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein yrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.
Biological Activity
Potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC 50 values are 0.8 and 19.4 mM respectively). Selective over EGFR and c-Src tyrosine kinases.
SU 4312 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 83)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Alfa Chemistry | United States | 24072 | 58 | Inquiry | |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | China | 12308 | 58 | Inquiry |
5812-07-7(SU 4312)Related Search:
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3-[[(4-DIMETHYLAMINO)PHENYL]METHYLENE]-1,3-DIHYDRO-2H-INDOL-2-ONE
3-(4-DIMETHYLAMINOBENZYLIDENYL)-2-INDOLINONE
3-[[(4-Dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one, E/Z mixture
NSC 86429
SU 4312
2H-Indol-2-one, 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro
(Z)-3-(4-(DIMETHYLAMINO)BENZYLIDENE)INDOLIN-2-ONE
SU4312(NSC86429)
SU 4312;NSC 86429;SU-4312;NSC-86429
PDGFR,Inhibitor,SU4312,VEGFR,inhibit,Vascular endothelial growth factor receptor,Platelet-derived growth factor receptor,SU-4312
5812-07-7
5812-7-7
Cell Biology
Cell Signaling and Neuroscience
BioChemical
Receptor Tyrosine Kinase Inhibitors
Kinase/Phosphatase Biology
Vascular Endothelial Growth Factor Receptor and Platelet-Derived Growth Factor Receptor (VEGFR1/2 and PDGFR)
Protein Kinase
Angiogenesis and Metastasis