MAZ51
- CAS No.
- 163655-37-6
- Chemical Name:
- MAZ51
- Synonyms
- MAZ51;CS-2885;MAZ51;MAZ-51;MAZ 51;VEGFR3 Kinase Inhibitor, MAZ;3-((4-(Dimethylamino)naphthalen-1-yl)methylene)indolin-2-one;3-(4-DIMETHYLAMINO-NAPHTHALEN-1-YLMETHYLENE)-1,3-DIHYDRO-INDOL-2-ONE;(3E)-3-[[4-(dimethylamino)naphthalen-1-yl]methylidene]-1H-indol-2-one;(3E)-3-{[4-(Dimethylamino)-1-naphthyl]methylene}-1,3-dihydro-2H-indol-2-one;2H-Indol-2-one, 3-[[4-(dimethylamino)-1-naphthalenyl]methylene]-1,3-dihydro-;EGFR,Apoptosis,growth,phosphorylation,Inhibitor,inhibit,PDGFRβ,MAZ51,MAZ 51,tumor,VEGF-D,indolinone,VEGFR,IGF-1R,VEGF-C,Vascular endothelial growth factor receptor,ligand-induced,MAZ-51,proliferation
- CBNumber:
- CB5393484
- Molecular Formula:
- C21H18N2O
- Molecular Weight:
- 314.38
- MOL File:
- 163655-37-6.mol
- Modify Date:
- 2023/6/8 9:02:17
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-37/38-41-51/53 | |||||||||
| Safety Statements | 26-39-61 | |||||||||
| RIDADR | UN 3077 9/PG 3 | |||||||||
| NFPA 704 |
|
MAZ51 price More Price(1)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 676492 | VEGFR3 Kinase Inhibitor, MAZ51 - CAS 163655-37-6 - Calbiochem The VEGFR3 Kinase Inhibitor, MAZ51, also referenced under CAS 163655-37-6, controls the biological activity of VEGFR3 Kinase. This small molecule/inhi | 163655-37-6 | 10MG | ₹16670.01 | 2022-06-14 | Buy |
| Product number | Packaging | Price | Buy |
|---|---|---|---|
| 676492 | 10MG | ₹16670.01 | Buy |
MAZ51 Chemical Properties,Uses,Production
Description
The VEGF receptors (VEGFRs) mediate signaling leading to angiogenesis, with VEGFR3 (FLT4), activated by VEGF isoforms VEGFC and VEGFD, primarily expressed on lymphatic endothelial cells and directing lymphangiogenesis. MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1 μM) without blocking VEGFC-mediated stimulation of VEGFR2. It does not inhibit ligand-induced autophosphorylation of EGFR, IGF-1R, or PDGFRβ. By preventing VEGFR3 activation, MAZ51 interferes with an autocrine loop involving the induced expression of the ligand VEGFC as well as VEGFA. It reduces proliferation and induces apoptosis in a variety of cancer cells in vitro and suppresses tumor growth in vivo. MAZ51 is used to study the role of VEGFR3 in endothelial and cancer cell function and survival.
Uses
MAZ51 is an indolinone compound that selectively antagonizes the activation of VEGFR-3 by VEGF-C without blocking VEGF-C mediated stumulation of VEGFR-2. This reduces proliferation and induces apoptosis in various cancer cells and suppresses tumor growth.
MAZ51 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| Alfa Chemistry | +1-5166625404 | United States | 21317 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| DC Chemicals | 021-58447131 13564518121 | China | 9412 | 58 | Inquiry |
| Shanghai jerryxing Biomedical Technology Co., Ltd | 17721492509 | China | 5347 | 58 | Inquiry |
| Guangdong Fangxin Biotechnology Co., Ltd. | 0751-2838688 13376594225 | China | 9936 | 58 | Inquiry |