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BMS 833923

CAS No.: 1059734-66-5

Chemical Name:: BMS 833923

Synonyms: XL139;CS-944;XL-139;XL 139;BMS 833923;BMS-833923 (XL-139);BMS 833923 USP/EP/BP;BMS 833923; BMS833923; XL-139; XL139; XL 139;N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide;Benzamide, N-[2-methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2-quinazolinyl)amino]-

CBNumber:: CB42658184

Molecular Formula:: C30H27N5O

Molecular Weight:: 473.57

MOL File:: 1059734-66-5.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:08

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BMS 833923 Properties

Density	1.252±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	≥47.4 mg/mL in DMSO; insoluble in H2O; ≥5.14 mg/mL in EtOH with gentle warming and ultrasonic
form	solid
pka	13.42±0.70(Predicted)
color	Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

NFPA 704

	0
2		0

BMS 833923 Chemical Properties,Uses,Production

Description

Smoothened (Smo) is a cell surface receptor that, with Patched, mediates sonic hedgehog (Shh) signaling to regulate gene expression through the Gli transcription factors. BMS 833923 is an orally bioavailable inhibitor of Smo. It blocks binding of BODIPY cyclopamine (IC₅₀ = 21 nM) and inhibits Gli activation in cell lines that express wild-type Smo or activated mutant forms of Smo (IC₅₀s = 6-35 nM). BMS 833923 robustly inhibits Shh pathway activity and prevents tumor growth in medulloblastoma and pancreatic carcinoma xenograft models.

BMS 833923 Preparation Products And Raw materials

Raw materials

Preparation Products

BMS 833923 Suppliers

Global( 97)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	25247	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	China	9991	58	Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	China	11681	58	Inquiry
Zhengzhou Anbu Chem Co.,Ltd	+86-0371-88006763; +8615988602810	China	3000	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Coresyn Pharmatech Co., Ltd.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Zhengzhou Anbu Chem Co.,Ltd	58

BMS 833923 Spectrum

BMS 833923(1059734-66-5)¹HNMR

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BMS 833923 XL 139 XL139 XL-139 BMS-833923 (XL-139) N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide Benzamide, N-[2-methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2-quinazolinyl)amino]- BMS 833923 N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide BMS-833923 BMS 833923; BMS833923; XL-139; XL139; XL 139 CS-944 BMS 833923 USP/EP/BP 1059734-66-5 Inhibitors