Glasdegib
- CAS No.
- 1095173-27-5
- Chemical Name:
- Glasdegib
- Synonyms
- CS-1041;EOS-60832;Glasdegib;PF 04449913;Glasdegib-D3;Glasdegib-D4;Glasdegib-13C6;Glasdegib-13C,15N;Glasdegib USP/EP/BP;PF04449913; PF 04449913
- CBNumber:
- CB82658197
- Molecular Formula:
- C21H22N6O
- Molecular Weight:
- 374.44
- MOL File:
- 1095173-27-5.mol
- Modify Date:
- 2023/12/28 17:21:45
| Melting point | >214°C (dec.) |
|---|---|
| Boiling point | 633.4±55.0 °C(Predicted) |
| Density | 1.33±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 11.93±0.10(Predicted) |
| color | Off-White |
| InChIKey | SFNSLLSYNZWZQG-VQIMIIECSA-N |
| SMILES | N([C@@H]1CCN(C)[C@@H](C2NC3=CC=CC=C3N=2)C1)C(NC1=CC=C(C#N)C=C1)=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361-H373 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501-P260-P314-P501 |
Glasdegib Chemical Properties,Uses,Production
Uses
Glasdegib acts as a potent, orally biovailablesmoothened (Smo) inhibitor used in the treatment of cancer.
Biochem/physiol Actions
PF-04449913 maleate salt is also known as 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea. It increases the differentiation of blood cells from hematopoietic precursors of the lymph gland medullary zone. This human Smo inhibitor protein is now under clinical trials to treat myeloid malignancies.
PF-04449913 (Glasdegib) is an orally bioavailable Hedgehog pathway inhibitor. PF-04449913 acts by binidng Smoothened (Smo) and blocking signal transduction. PF-04449913 has an IC50 of 5 nM in the Gli-Luciferase assay. In a Phase I clinical trial in patients with advanced solid tumors, PF-04449913 caused disease stabilization in 34% of patients.
Glasdegib Preparation Products And Raw materials
Glasdegib Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Suzhou Ryan Pharmachem Technology Co.,Ltd. | +86-512-68780025 +8618962125825 | China | 137 | 58 | Inquiry |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | China | 7287 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |
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