SE 563

SE 563 Structure
CAS No.
174819-21-7
Chemical Name:
SE 563
Synonyms
SE 563;Efavirenz Impurity 15;Efavirenz N-Methoxybenzyl Impurity;(S)-6-Chloro-4-(cyclopropylethynyl)-1-(4-methoxybenzyl)-4-(trifluoromethyl)-1,4-dihydro-2H-benzo[d][;(4S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-1-[(4-methoxyphenyl)methyl]-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one;2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-1-[(4-methoxyphenyl)methyl]-4-(trifluoromethyl)-, (4S)-
CBNumber:
CB42710064
Molecular Formula:
C22H17ClF3NO3
Molecular Weight:
435.82
MOL File:
174819-21-7.mol
Modify Date:
2023/4/23 13:52:06

SE 563 Properties

Melting point 112-114°C
Boiling point 529.9±50.0 °C(Predicted)
Density 1.44±0.1 g/cm3(Predicted)
storage temp. Amber Vial, -20°C Freezer, Under inert atmosphere
solubility Chloroform (Slightly), Methanol (Slightly)
pka -2.47±0.40(Predicted)
form Solid
color White to Off-White
Stability Light Sensitive

SE 563 Chemical Properties,Uses,Production

Uses

SE 563 is used in the synthesis of an HIV-1 reverse trancriptase inhibitor, Efavirenz (E425000).

SE 563 Preparation Products And Raw materials

Raw materials

Preparation Products

Efavirenz Impurity 15 Efavirenz N-Methoxybenzyl Impurity (S)-6-Chloro-4-(cyclopropylethynyl)-1-(4-methoxybenzyl)-4-(trifluoromethyl)-1,4-dihydro-2H-benzo[d][ (4S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-1-[(4-methoxyphenyl)methyl]-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one 2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-1-[(4-methoxyphenyl)methyl]-4-(trifluoromethyl)-, (4S)- SE 563 174819-21-7