3H-1,2,4-Triazol-3-one, 2-[(1S,2S)-1-ethyl-2-hydroxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-

CAS No.: 687132-01-0

Chemical Name:: 3H-1,2,4-Triazol-3-one, 2-[(1S,2S)-1-ethyl-2-hydroxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-

Synonyms: 2-[(2S,3S)-2-Hydroxypentan-3-yl]-4-[4-[4-(4-hydroxyphenyl)piperazin-1-yl]phenyl]-1,2,4-triazol-3-one;1-((2S,3S)-2-hydroxypentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one;2-((2S,3S)-2-Hydroxypentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one;2-[(1S,2S)-1-Ethyl-2-hydroxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one;1-((2S,3S)-2-hydroxypentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one dihydrochloride

CBNumber:: CB42716031

Molecular Formula:: C23H29N5O3

Molecular Weight:: 423.51

MOL File:: 687132-01-0.mol

Modify Date:: 2024/7/11 17:04:31

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3H-1,2,4-Triazol-3-one, 2-[(1S,2S)-1-ethyl-2-hydroxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]- Properties

Melting point	186 - 193°C
Boiling point	635.9±65.0 °C(Predicted)
Density	1.29±0.1 g/cm3(Predicted)
storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
form	Solid
pka	12.18±0.30(Predicted)
color	White to Off-White
Stability	Hygroscopic

3H-1,2,4-Triazol-3-one, 2-[(1S,2S)-1-ethyl-2-hydroxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]- Chemical Properties,Uses,Production

Uses

2-[(1S,2S)-1-Ethyl-2-hydroxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one is used as a reactant in the process for the preparation of antifungal agent posaconazole and its intermediates.

3H-1,2,4-Triazol-3-one, 2-[(1S,2S)-1-ethyl-2-hydroxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

3H-1,2,4-Triazol-3-one, 2-[(1S,2S)-1-ethyl-2-hydroxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]- Suppliers

Global( 27)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
ShenZhen H&D Pharmaceutical Technology Co., LTD	+86-0755-22677845 +86-13627253706	China	3389	58	Inquiry
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	China	23556	58	Inquiry
China National Standard Pharmaceutical Corporation Limited	+8615391658522	China	11927	58	Inquiry
Shanghai Zerui Biotechnology Co., Ltd.	021-54580889 18321124657	China	10614	58	Inquiry
BOC Sciences	1-631-485-4226; 16314854226	United States	14059	65	Inquiry
Guangzhou Zhenlin Pharmaceutical Technology Co., Ltd	18102736234 18102736234	China	7664	58	Inquiry
Nantong Hanfang Biotechnology Co. , Ltd.	18616537568	China	30968	58	Inquiry
Cato Research Chemicals Inc.	020-81960175-877 18933936954	China	7730	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
ShenZhen H&D Pharmaceutical Technology Co., LTD	58
ANHUI WITOP BIOTECH CO., LTD	58
China National Standard Pharmaceutical Corporation Limited	58
Shanghai Zerui Biotechnology Co., Ltd.	58
BOC Sciences	65
Guangzhou Zhenlin Pharmaceutical Technology Co., Ltd	58
Nantong Hanfang Biotechnology Co. , Ltd.	58
Cato Research Chemicals Inc.	58

687132-01-0(3H-1,2,4-Triazol-3-one, 2-[(1S,2S)-1-ethyl-2-hydroxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-)Related Search:

4-(4-{4-[(3R,5R)-5-(2,4-DIFLUORO-PHENYL)-5-[1,2,4]TRIAZOL-1-YLMETHYL-TETRAHYDRO-FURAN-3-YLMETHOXY]-PHENYL}-PIPERAZIN-1-YL)-PHENYLAMINE Posaconazole Impurity 43 Posaconazole inter-8 Posaconazole Impurity 43 Posaconazole Impurity 51

(S)-2-(BENZYLOXY)PROPIONAL Posaconazole Impurity 47 Posaconazole Impurity 42 (S)-[2-(Benzyloxy)propylidene]hydrazinecarboxaldehyde 2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxaldehyde

1-(((2R,4R)-4-((Benzyloxy)methyl)-2-(2,4-difluorophenyl)tetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazole Posaconazole Impurity 50 D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-(1-ethylpropyl)-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]Methyl]-1-(1H-1,2,4-triazol-1-yl)- 1,3-PROPANEDIOL, 2-[2-(2,4-DIFLUOROPHENYL)-2-PROPEN-1-YL]- Posaconazole Impurity 24

1-[(2S)-2-(benzyloxy)propanoyl]pyrrolidine PHENYL {4-[4-(4-HYDROXYPHENYL)PIPERAZIN-1-YL]PHENYL}CARBAMATE Posaconazole Impurity 49

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1-((2S,3S)-2-hydroxypentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one 1-((2S,3S)-2-hydroxypentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one dihydrochloride 2-[(1S,2S)-1-Ethyl-2-hydroxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one 2-[(2S,3S)-2-Hydroxypentan-3-yl]-4-[4-[4-(4-hydroxyphenyl)piperazin-1-yl]phenyl]-1,2,4-triazol-3-one 2-((2S,3S)-2-Hydroxypentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one 687132-01-0