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PFK-158

PFK-158 Structure
CAS No.
1462249-75-7
Chemical Name:
PFK-158
Synonyms
PFK-158;PFK-158;PFK 158;PFK-158 free base;PFK-158, ACT-PFK-158;(E)-1-(4-Pyridyl)-3-[7-(trifluoromethyl)-2-quinolyl]-2-propen-1-one;(2E)-1-(4-Pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-2-propen-1-one;(E)-1-(Pyridin-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)prop-2-en-1-one;2-Propen-1-one, 1-(4-pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-, (2E)-;p-cPLA2,inhibit,anti-proliferative,Autophagy,PFK 158,LC3BII,glycolysis,Inhibitor,PFK158,anti-tumor,PFK-158,Apoptosis,lactate,PFKFB3
CBNumber:
CB43034954
Molecular Formula:
C18H11F3N2O
Molecular Weight:
328.29
MOL File:
1462249-75-7.mol
Modify Date:
2024/7/2 8:55:08
Request For Quotation

PFK-158 Properties

Boiling point 466.3±45.0 °C(Predicted)
Density 1.346±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:14.0(Max Conc. mg/mL);42.6(Max Conc. mM)
form A crystalline solid
pka 2.46±0.10(Predicted)
color White to light yellow

PFK-158 price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML3145 PFK-158 ≥98% (HPLC) 1462249-75-7 5MG ₹8356.9 2022-06-14 Buy
Sigma-Aldrich(India) SML3145 PFK-158 ≥98% (HPLC) 1462249-75-7 25MG ₹33730.7 2022-06-14 Buy
Product number Packaging Price Buy
SML3145 5MG ₹8356.9 Buy
SML3145 25MG ₹33730.7 Buy

PFK-158 Chemical Properties,Uses,Production

Description

PFK158 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3; IC50 = 137 nM for human recombinant PFKFB3). It inhibits PFKFB3 and glycolysis in Jurkat cells (IC50s = 1.6 and 0.847 μM, respectively). PFK158 inhibits the growth of leukemia cells in vitro (IC50 = 0.33 μM for Jurkat cells) and reduces tumor volume in CT-26 murine colon carcinoma syngeneic model and a BxPC-3 pancreatic cancer mouse xenograft model. PFK158 also enhances activity of the anti-CTLA-4 antibody in the B16/F10 mouse model of melanoma.

PFK-158 Preparation Products And Raw materials

Raw materials

Preparation Products

PFK-158 Suppliers

Global( 64)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
Shenzhen Nexconn Pharmatechs Ltd +86-755-89396905 +86-15013857715 China 10259 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Hebei Miaoyin Technology Co.,Ltd +86-17367732028 +86-17367732028 China 3582 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Jiangsu shring Biopharma Co., Ltd. +8613372282299 China 3545 58 Inquiry
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
Shenzhen Nexconn Pharmatechs Ltd 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
TargetMol Chemicals Inc. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Hebei Miaoyin Technology Co.,Ltd 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58
Jiangsu shring Biopharma Co., Ltd. 58

1462249-75-7(PFK-158)Related Search:

PFK-015 Silver
PFK-158 PFK-158, ACT-PFK-158 (2E)-1-(4-Pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-2-propen-1-one PFK-158;PFK 158 PFK-158 free base 2-Propen-1-one, 1-(4-pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-, (2E)- (E)-1-(Pyridin-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)prop-2-en-1-one p-cPLA2,inhibit,anti-proliferative,Autophagy,PFK 158,LC3BII,glycolysis,Inhibitor,PFK158,anti-tumor,PFK-158,Apoptosis,lactate,PFKFB3 (E)-1-(4-Pyridyl)-3-[7-(trifluoromethyl)-2-quinolyl]-2-propen-1-one 1462249-75-7 1462249-75-1 C18H11F3N2O