PFK-158
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- ₹8356.9 - ₹33730.7
- Product name: PFK-158
- CAS: 1462249-75-7
- MF: C18H11F3N2O
- MW: 328.29
- EINECS:
- MDL Number:
- Synonyms:PFK-158;PFK-158, ACT-PFK-158;(2E)-1-(4-Pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-2-propen-1-one;PFK-158;PFK 158;PFK-158 free base;2-Propen-1-one, 1-(4-pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-, (2E)-;(E)-1-(Pyridin-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)prop-2-en-1-one;p-cPLA2,inhibit,anti-proliferative,Autophagy,PFK 158,LC3BII,glycolysis,Inhibitor,PFK158,anti-tumor,PFK-158,Apoptosis,lactate,PFKFB3
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML3145
- Product descriptionPFK-158 ≥98% (HPLC)
- Packaging5MG
- Price₹8356.9
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML3145
- Product descriptionPFK-158 ≥98% (HPLC)
- Packaging25MG
- Price₹33730.7
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML3145 | PFK-158 ≥98% (HPLC) | 5MG | ₹8356.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML3145 | PFK-158 ≥98% (HPLC) | 25MG | ₹33730.7 | 2022-06-14 | Buy |
Properties
Boiling point :466.3±45.0 °C(Predicted)
Density :1.346±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:14.0(Max Conc. mg/mL);42.6(Max Conc. mM)
form :A crystalline solid
pka :2.46±0.10(Predicted)
color :White to light yellow
Density :1.346±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:14.0(Max Conc. mg/mL);42.6(Max Conc. mM)
form :A crystalline solid
pka :2.46±0.10(Predicted)
color :White to light yellow
Safety Information
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Description
PFK158 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3; IC50 = 137 nM for human recombinant PFKFB3). It inhibits PFKFB3 and glycolysis in Jurkat cells (IC50s = 1.6 and 0.847 μM, respectively). PFK158 inhibits the growth of leukemia cells in vitro (IC50 = 0.33 μM for Jurkat cells) and reduces tumor volume in CT-26 murine colon carcinoma syngeneic model and a BxPC-3 pancreatic cancer mouse xenograft model. PFK158 also enhances activity of the anti-CTLA-4 antibody in the B16/F10 mouse model of melanoma.Suppliers and manufacturers
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