PFK-015
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- ₹11528.63 - ₹46515.03
- Product name: PFK-015
- CAS: 4382-63-2
- MF: C17H12N2O
- MW: 260.29
- EINECS:
- MDL Number:MFCD28099813
- Synonyms:2-Propen-1-one, 1-(4-pyridinyl)-3-(2-quinolinyl)-;1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one PFK15;1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one;PFK-015;1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one;PFK015;PFK15;PFK 15;PFK-15;CS-1317;PFK15 (PFK-015)
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML1009
- Product descriptionPFK15 ≥98% (HPLC)
- Packaging5MG
- Price₹11528.63
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1009
- Product descriptionPFK15 ≥98% (HPLC)
- Packaging25MG
- Price₹46515.03
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1009 | PFK15 ≥98% (HPLC) | 5MG | ₹11528.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1009 | PFK15 ≥98% (HPLC) | 25MG | ₹46515.03 | 2022-06-14 | Buy |
Properties
Boiling point :464.4±45.0 °C(Predicted)
Density :1.237±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: soluble10mg/mL, clear
pka :3.11±0.61(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Density :1.237±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: soluble10mg/mL, clear
pka :3.11±0.61(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Safety Information
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Description
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) is a bifunctional enzyme that contains distinct domains for the phosphorylation of fructose 6-phosphate and the dephosphorylation of fructose 2,6-bisphosphate. PFKFB3 protein expression is elevated in most tumor types. PFK15 is a selective inhibitor of PFKFB3 (IC50 = 207 nM). It has no significant inhibitory effect on any member of a panel of 96 other kinases, and does not inhibit purified 6-phosphofructo-1-kinase, hexokinase, phosphoglucose isomerase, or PFKFB4. PFK15 rapidly induces apoptosis in transformed cells, suppresses glucose uptake and growth of Lewis lung carcinomas in syngeneic mice, and yields antitumor effects in human xenograft models of cancer in athymic mice.More related product prices
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