Pioglitazone
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- Product name: Pioglitazone
- CAS: 111025-46-8
- MF: C19H20N2O3S
- MW: 356.44
- EINECS:601-029-7
- MDL Number:MFCD00865504
- Synonyms:Pioglitazone;5-[4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl]thiazolidine-2,4-dione;PIOGLITAZONE HCL(5-[[4-[2-(5-ETHYLPYRIDIN-2-YL)ETHOXY]PHENYL]METHYL]THIAZOLIDINE-2,4-DIONE, HCL);PINEPOLLEN;5-[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]benzyl]thiazolidine-2,4-dione;Pioglitazone (Actos);2,4-Thiazolidinedione,5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]Methyl]-;Pioglitazone 5-[[4-[2-(5-Ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
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Properties
Melting point :183-184 C
Boiling point :575.4±45.0 °C(Predicted)
Density :1.260±0.06 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2-8°C
solubility :DMSO (Slightly, Heated)
form :White to off-white solid.
pka :6.35±0.50(Predicted)
color :White to Off-White
IARC :2A (Vol. 108) 2016
Boiling point :575.4±45.0 °C(Predicted)
Density :1.260±0.06 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2-8°C
solubility :DMSO (Slightly, Heated)
form :White to off-white solid.
pka :6.35±0.50(Predicted)
color :White to Off-White
IARC :2A (Vol. 108) 2016
Safety Information
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Description
Thiazolidinediones (TZDs) are a group of structurally related PPARγ agonists with anti-diabetic actions in vivo. Rosiglitazone (BRL49653) is a prototypical TZD and has served as a reference compound for this class of PPARγ ligands. Pioglitazone is a closely related TZD which also selectively activates PPARγ-1. Pioglitazone is about one tenth as potent as rosiglitazone, with an EC50 of about 500-600 nM for both human and mouse PPARγ. In a transactivation assay using COS-1 cells transfected with full length human PPARα and RXRα, pioglitazone and rosiglitazone exhibit low level activation of PPARα at 1 μM and 5.4- and 4.2-fold activation, respectively, at a concentration of 10 μM.More related product prices
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