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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Epigenetics >Epigenetic Reader Domain inhibitors >MS436

MS436

MS436 Structure
  • ₹0
  • Product name: MS436
  • CAS: 1395084-25-9
  • MF: C18H17N5O3S
  • MW: 383.42
  • EINECS:
  • MDL Number:MFCD27992062
  • Synonyms:4-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide;4-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide MS436;MS436 4-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide;MS 436, >=98%;MS436;(E)-4-((2-AMINO-4-HYDROXY-5-METHYLPHENYL)DIAZENYL)-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE;(E)-4-[2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide;MS-436; MS 436
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :673.7±65.0 °C(Predicted)
Density :1.42±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; insoluble in EtOH; ≥19.15 mg/mL in DMSO
form :solid
pka :9.25±0.36(Predicted)
color :Pink to red

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

MS436, through a set of water-mediated interactions, exhibits low nanomolar affinity (estimated Ki of 30-50 nM) with preference for the first bromodomain over the second. MS436 effectively blocks BRD4 transcriptional activity in lipopolysaccharide-induced production of both nitric oxide and IL-6 in mouse macrophages (IC50 values are 3.8 and 4.9 ?M, respectively). MS436 represents a new class of bromodomain inhibitors and will facilitate further investigation of the biological functions of the two bromodomains of BRD4 in gene expression.

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Suppliers and manufacturers

career henan chemical co
(E)-4-((2-AMINO-4-HYDROXY-5-METHYLPHENYL)DIAZENYL)-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE
₹1.00 /1KG
(E)-4-((2-AMINO-4-HYDROXY-5-METHYLPHENYL)DIAZENYL)-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE CAS:1395084-25-9
A.J Chemicals CLEARSYNTH LABS LTD.
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
TargetMol Chemicals Inc.
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
ShenZhen Trendseen Biological Technology Co.,Ltd.