PFI-1

₹12925.05 - ₹49697.58
Product name: PFI-1
CAS: 1403764-72-6
MF: C16H17N3O4S
MW: 347.39
EINECS:
MDL Number:MFCD22580416
Synonyms:PFI-1;PFI-1 (PF-6405761);PFI-1 (PF-06405761);PFI 1;PFI1;CS-709;PF-06405761;Benzenesulfonamide, 2-methoxy-N-(1,2,3,4-tetrahydro-3-methyl-2-oxo-6-quinazolinyl)-;2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide PFI-1 (PF-6405761)

Price2 Properties Safety Information Description

2 prices

Selected condition：

Brand

Sigma-Aldrich(India)

Package

5MG
25MG

ManufacturerSigma-Aldrich(India)
Product numberSML0352
Product descriptionPFI-1 ≥98% (HPLC)
Packaging5MG
Price₹12925.05
Updated2022-06-14
Buy

ManufacturerSigma-Aldrich(India)
Product numberSML0352
Product descriptionPFI-1 ≥98% (HPLC)
Packaging25MG
Price₹49697.58
Updated2022-06-14
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SML0352	PFI-1 ≥98% (HPLC)	5MG	₹12925.05	2022-06-14	Buy
Sigma-Aldrich(India)	SML0352	PFI-1 ≥98% (HPLC)	25MG	₹49697.58	2022-06-14	Buy

Properties

storage temp. :Sealed in dry,2-8°C
solubility :DMSO: ≥10mg/mL
form :powder
color :white to beige

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Bromodomains recognize acetylated lysine residues and recruit regulatory complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. The isolated individual or tandem bromodomains of bromodomain-containing protein (BRD) 2 and BRD4 bind acetylated histone tails, which couples histone acetylation marks to the transcriptional regulation of target promoters. Small molecule inhibitors of bromodomain interactions hold promise as useful therapeutics for human disease. PFI-1 is a BET bromodomain inhibitor that exhibits inhibitory activity at BRD2 and BRD4. In an AlphaScreen assay it has been shown to inhibit BRD2 bromodomain 2 and BRD4 bromodomain 1 with IC50 values of 98 nM and 0.22 μM, respectively. See the Structural Genomics Consortium (SGC) website for more information.

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