GSK 525762A
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- ₹9380 - ₹54547.18
- Product name: GSK 525762A
- CAS: 1260907-17-2
- MF: C22H22ClN5O2
- MW: 423.9
- EINECS:
- MDL Number:MFCD30207861
- Synonyms:I-BET-762;GSK 525762A (I-BET-762);GSK525762 (I-BET-762);GSK525762;4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine-4-acetamide, 6-(4-chlorophenyl)-N-ethyl-8-methoxy-1-methyl-, (4S)-;(4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide GSK 525762A I-BET-762;GSK 525762A (4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide;IBET762(GSK525762A)
3 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product number401010
- Product descriptionI-BET - CAS 1260907-17-2 - Calbiochem A cell-permeable benzodiazepine compound that binds the tandem bromodomains of BET (bromodomain and extra terminal domain) family members BRD2 (1-473)
- Packaging5MG
- Price₹9380
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1272
- Product descriptionI-BET762 ≥98% (HPLC)
- Packaging5MG
- Price₹13423
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1272
- Product descriptionI-BET762 ≥98% (HPLC)
- Packaging25MG
- Price₹54547.18
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 401010 | I-BET - CAS 1260907-17-2 - Calbiochem A cell-permeable benzodiazepine compound that binds the tandem bromodomains of BET (bromodomain and extra terminal domain) family members BRD2 (1-473) | 5MG | ₹9380 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML1272 | I-BET762 ≥98% (HPLC) | 5MG | ₹13423 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML1272 | I-BET762 ≥98% (HPLC) | 25MG | ₹54547.18 | 2022-06-14 | Buy |
Properties
Melting point :>132°C (dec.)
Density :1.35
storage temp. :2-8°C
solubility :Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml)
pka :15.71±0.46(Predicted)
form :powder
color :white to beige
optical activity :[α]/D +80 to +90°, c = 0.3 in methanol
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Density :1.35
storage temp. :2-8°C
solubility :Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml)
pka :15.71±0.46(Predicted)
form :powder
color :white to beige
optical activity :[α]/D +80 to +90°, c = 0.3 in methanol
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Safety Information
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Description
The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, affect inflammatory gene expression by controlling the assembly of histone acetylation-dependent chromatin complexes. I-BET762 is a synthetic compound which interacts with BET proteins with high-affinity (Kd = 32.5-42.5 nM). It blocks binding of BET proteins with acetylated histones, disrupting the formation of chromatin complexes involved in the expression of specific inflammatory genes in activated macrophages. Through these actions, I-BET762 provides protection against bacteria-induced sepsis and lipopolysaccharide-triggered endotoxic shock.More related product prices
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