A 769662
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- ₹0
- Product name: A 769662
- CAS: 844499-71-4
- MF: C20H12N2O3S
- MW: 360.39
- EINECS:
- MDL Number:MFCD11977269
- Synonyms:A 769662;4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile;Thieno[2,3-b]pyridine-5-carbonitrile, 6,7-dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-;A-769662/A769662;4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitri;A-769622;A-769662 4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile
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Properties
Melting point :263 - 266oC
Boiling point :630.1±55.0 °C(Predicted)
Density :1.56
Flash point :334.9℃
storage temp. :Keep in dark place,Sealed in dry,Room Temperature
solubility :Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 5 mg/ml),
form :solid
pka :4.50±1.00(Predicted)
color :Beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Boiling point :630.1±55.0 °C(Predicted)
Density :1.56
Flash point :334.9℃
storage temp. :Keep in dark place,Sealed in dry,Room Temperature
solubility :Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 5 mg/ml),
form :solid
pka :4.50±1.00(Predicted)
color :Beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Safety Information
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Description
AMP-activated protein kinase (AMPK) is an αβγ heterotrimer that functions as a metabolic sensor, regulating lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress. A-769662 is a small molecule thienopyridone that activates AMPK directly in cell-free assays (EC50 = 116 nM) and intact cells by allosterically activating AMPK and inhibiting its dephosphorylation on Thr172. A-769662 specifically activates β1 subunit-containing AMPK heterotrimers, and its effects are independent of kinases upstream of AMPK. A-769662 has been used to stimulate CYP450-mediated fatty acid oxidation, inhibit adipocyte differentiation, explore glucose uptake in skeletal muscle, and promote endothelial cell survival during metabolic stress.Related product price
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