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(3N-[(2S,3S)-2-AMINO-3-METHYL-PENTANOYL]-1,3-THIAZOLIDINE) HEMIFUMARATE

(3N-[(2S,3S)-2-AMINO-3-METHYL-PENTANOYL]-1,3-THIAZOLIDINE) HEMIFUMARATE Structure
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :351.8±37.0 °C(Predicted)
Density :1.118±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 25 mg/ml) or in Water (up to 20 mg/ml).
pka :8.53±0.39(Predicted)
form :White solid.
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.

Description

P32/98 is a specific, competitive transition-state substrate analog inhibitor of dipeptidyl peptidase IV (DPIV, DPPIV, and CD26). In obese Zucker and lean rats the inhibition of CD26's ability to hydrolyze Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide (GLP-1) lead to an increased secretion of insulin, especially in the obsese Rat, making P32/98 an important tool in diabetic research. P32/ 98 has also been shown to augment YY1-36's ability to enhance renovascular responses to angiotensin II in spontaneoulsy hypertensive rats. Due to CD26's effect on upregultating lymphocyte proliferation P32/98 has been demonstrated to decrease the lymphocyte proliferation.

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AICAR GW9508 866405-64-3 AR-A014418

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Suppliers and manufacturers

Aladdin Scientific TargetMol Chemicals Inc. Biomol Feinchemikalien GmbH Service Chemical Inc. BIOMOL INTERNATIONAL, LP United States Biological Focus Biomolecules Shanghai EFE Biological Technology Co., Ltd.