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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Pyridine compound >Hydroxypyridine >A 769662

A 769662

A 769662 Structure
CAS No.
844499-71-4
Chemical Name:
A 769662
Synonyms
CS-18;A 769662;A-769622;A-769662, >=98%;A-769662/A769662;A 769662 ISO 9001：2015 REACH;A 769662 (This product is unavailable in the U.S.);4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6;4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile;4,6-dihydroxy-3-{2'-hydroxy-[1,1'-biphenyl]-4-yl}thi eno[2,3-b]pyridine-5-carbonitrile
CBNumber:
CB31871930
Molecular Formula:
C20H12N2O3S
Molecular Weight:
360.39
MOL File:
844499-71-4.mol
Modify Date:
2023/6/30 15:45:59
Request For Quotation

A 769662 Properties

Melting point 263 - 266oC
Boiling point 630.1±55.0 °C(Predicted)
Density 1.56
Flash point 334.9℃
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 5 mg/ml),
form solid
pka 4.50±1.00(Predicted)
color Beige
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H312-H332-H319
Precautionary statements  P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312-P264-P280-P305+P351+P338-P337+P313P
Safety Statements  24/25
HS Code  29333990
NFPA 704
0
3 0

A 769662 Chemical Properties,Uses,Production

Description

A-769662 is a small molecule thienopyridone that activates AMPK directly in cell-free assays (EC50 = 116 nM) and intact cells by allosterically activating AMPK and inhibiting its dephosphorylation on Thr172. A-769662 specifically activates β1 subunit-containing AMPK heterotrimers, and its effects are independent of kinases upstream of AMPK. A-769662 has been used to stimulate CYP450-mediated fatty acid oxidation, inhibit adipocyte differentiation, explore glucose uptake in skeletal muscle, and promote endothelial cell survival during metabolic stress.

Biological Activity

Potent, reversible AMP-activated protein kinase (AMPK) activator (EC 50 = 0.8 μ M) that displays selectivity towards β 1 subunit-containing heterotrimers. Inhibits fatty acid synthesis (IC 50 = 3.2 μ M) and decreases plasma glucose and triglyceride levels in vivo .

A 769662 Preparation Products And Raw materials

Raw materials

Preparation Products

A 769662 Suppliers

Global( 149)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
Hangzhou FandaChem Co.,Ltd. 008657128800458; +8615858145714 China 9338 55 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
Shenzhen Nexconn Pharmatechs Ltd +86-755-89396905 +86-15013857715 China 10260 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
ANHUI WITOP BIOTECH CO., LTD +8615255079626 China 23556 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26063 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Capot Chemical Co.,Ltd. 60
Hangzhou FandaChem Co.,Ltd. 55
ATK CHEMICAL COMPANY LIMITED 60
Shenzhen Nexconn Pharmatechs Ltd 58
TargetMol Chemicals Inc. 58
ANHUI WITOP BIOTECH CO., LTD 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58

A 769662 Spectrum

A 769662(844499-71-4)1HNMR

844499-71-4(A 769662)Related Search:

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A 769662 4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile 6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile Thieno[2,3-b]pyridine-5-carbonitrile, 6,7-dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo- A-769662/A769662 4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitri A-769622 A-769662 4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile A-769662, >=98% 4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboni A 769662 ISO 9001：2015 REACH 4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile CS-18 4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6 4,6-dihydroxy-3-{2'-hydroxy-[1,1'-biphenyl]-4-yl}thi eno[2,3-b]pyridine-5-carbonitrile A 769662 (This product is unavailable in the U.S.) 4-Hydroxy-3-(2’-hydroxy-4-biphenylyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile 4-Hydroxy-3-(2’-hydroxy-4-biphenylyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile 4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile 6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile 844499-71-4 C20H12N2O3S Inhibitors Akt mTOR PI3K APIs Signalling