Glibenclamide
- CAS No.
- 10238-21-8
- Chemical Name:
- Glibenclamide
- Synonyms
- GLYBURIDE;GLYBENCLAMIDE;Diabeta;Glynase;Glibenclamid;GIBENCLAMIDE;GLYBENZCYCLAMIDE;5-Chloro-N-(4-(N-(cyclohexylcarbaMoyl)sulfaMoyl)phenethyl)-2-MethoxybenzaMide;adiab;Malix
- CBNumber:
- CB1737679
- Molecular Formula:
- C23H28ClN3O5S
- Molecular Weight:
- 494
- MOL File:
- 10238-21-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/2/21 21:32:25
| Melting point | 173-175°C |
|---|---|
| Density | 1.1805 (rough estimate) |
| refractive index | 1.6100 (estimate) |
| storage temp. | 2-8°C |
| solubility | ethanol: soluble2mg/mL |
| form | White solid |
| pka | 5.3(at 25℃) |
| color | White |
| Water Solubility | Soluble in ethanol (5 mg/mL), DMSO (25 mg/mL), chloroform (1:36), methanol (1:250), and DMF. Insoluble in water. |
| Merck | 14,4478 |
| BCS Class | 2 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| InChIKey | ZNNLBTZKUZBEKO-UHFFFAOYSA-N |
| CAS DataBase Reference | 10238-21-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Glyburide(10238-21-8) |
| EPA Substance Registry System | Benzamide, 5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy- (10238-21-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H370 | |||||||||
| Precautionary statements | P260-P264-P270-P308+P311-P405-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22 | |||||||||
| Safety Statements | 22-36/37/39-36-24/25 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | YS4725200 | |||||||||
| HS Code | 29350090 | |||||||||
| Toxicity | LD50 in rats and mice (g/kg): >20 orally; >12.5 i.p.; >20 s.c. (Mizukami) | |||||||||
| NFPA 704 |
|
Glibenclamide price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR1287 | Glyburide (Glibenclamide) Pharmaceutical Secondary Standard; Certified Reference Material | 10238-21-8 | 1G | ₹8107.93 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G2539 | Glyburide meets USP testing specifications | 10238-21-8 | 5G | ₹14906.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G2539 | Glyburide meets USP testing specifications | 10238-21-8 | 10G | ₹16172.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G0639 | Glybenclamide ≥99% (HPLC) | 10238-21-8 | 5G | ₹10987.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G0639 | Glybenclamide ≥99% (HPLC) | 10238-21-8 | 10G | ₹20830 | 2022-06-14 | Buy |
Glibenclamide Chemical Properties,Uses,Production
Chemical Properties
White or almost white, crystalline powder
Uses
Glyburide (Glibenclamide) is a sulfonylurea compound that modulates insulin production. Sulfonylureas bind to ATP-dependent K+ channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turn stimulates insulin production. Glyburide (Glibenclamide) is an ATP-dependent K+ channel (KIR6, KATP) and CFTR Cl- channel blocker. This compound inhibits recombinant CFTR Cl- channels (IC50 = 20 ?M).
Definition
ChEBI: An N-sulfonylurea that is acetohexamide in which the acetyl group is replaced by a 2-(5-chloro-2-methoxybenzamido)ethyl group.
General Description
Glyburide (glibenclamide) is 5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxybenzamide; this compound can also be named asthe urea—see preceding discussion (Diabeta, Glynase,generic). Some tablet formulations contain micronized drug(formerly Micronase, now only generic). Combinations areavailable with metformin in the United States (Glucovance,generic; tablets, mg glipizide/mg metformin as hydrochloride:1.25/250, 2.5/500, 5/500).
Biological Activity
ATP-dependent K + channel (K ATP ) and CFTR Cl - channel blocker. Inhibits K ATP currents in the pancreas, causing an increase in intracellular Ca 2+ and insulin secretion. Inhibits recombinant CFTR Cl- channels with an IC 50 of 20 μ M.
Mechanism of action
This drug belongs to the second-generation sulfonylurea derivatives. Like all of the other oral hypoglycemic drugs examined, it is a β-cell stimulant in pancreas; but on the other hand, it increases the sensitivity to insulin, the degree to which it binds with target cells. At the same time, it differs in that it is easier to tolerate. The hypoglycemic effect sets in at significantly lower doses than with first-generation drugs.
Glibenclamide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Cadila Pharmaceuticals Ltd | +91-7069076657 +91-7069076657 | Ahmedabad, India | 53 | 58 | Inquiry |
| ANWITA APIS | +919000311012 | Hyderabad, India | 195 | 58 | Inquiry |
| Frolic Pharmachem | +919711094561 | Himachal Pradesh, India | 94 | 58 | Inquiry |
| USV Pvt Ltd | +91-2267861111 +91-2225564048 | Maharashtra, India | 36 | 58 | Inquiry |
| Ions Pharma | +912266707500 | Maharashtra, India | 89 | 58 | Inquiry |
| WARUKSHA LABORATORIES PVT LTD | +91-7485988764 +91-7485988764 | Gujarat, India | 77 | 58 | Inquiry |
| Elixir Pharma | +91-9712378624 +91-9558826007 | Gujarat, India | 22 | 58 | Inquiry |
| Prudence Pharma Chem | +91-9624042444 +91-9825205460 | Gujarat, India | 32 | 58 | Inquiry |
| Sri Krishna Pharmaceuticals Ltd | +91-4027177825 +91-8886992503 | Telangana, India | 13 | 58 | Inquiry |
| Heer Pharma Pvt Ltd | +91-9820051881 +91-9820051881 | Maharashtra, India | 101 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Cadila Pharmaceuticals Ltd | 58 |
| ANWITA APIS | 58 |
| Frolic Pharmachem | 58 |
| USV Pvt Ltd | 58 |
| Ions Pharma | 58 |
| WARUKSHA LABORATORIES PVT LTD | 58 |
| Elixir Pharma | 58 |
| Prudence Pharma Chem | 58 |
| Sri Krishna Pharmaceuticals Ltd | 58 |
| Heer Pharma Pvt Ltd | 58 |
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