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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >PI3K / Akt / mTOR >GSK-3 inhibitors >BIO

BIO

BIO Structure
CAS No.
667463-62-9
Chemical Name:
BIO
Synonyms
Z E;6BIO;CS-1934;MLS2052;GSK 3 IX;MLS 2052;BIO (SM04554);BIO USP/EP/BP;GSK3 Inhibitor IX1;BIO(GSK-3 Inhibitor IX
CBNumber:
CB5496994
Molecular Formula:
C16H10BrN3O2
Molecular Weight:
356.17
MOL File:
667463-62-9.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
Request For Quotation

BIO Properties

Melting point 300°C(lit.)
Boiling point 554.3±50.0 °C(Predicted)
Density 1.80±0.1 g/cm3(Predicted)
RTECS NM3241900
storage temp. 2-8°C
solubility DMSO: >5 mg/mL
form solid
pka 9.56±0.20(Predicted)
color dark red
Sensitive Air & Light Sensitive
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
HS Code  29339900
NFPA 704
0
2 0

BIO price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) B1686 BIO ≥98% (HPLC) 667463-62-9 5MG ₹16421.53 2022-06-14 Buy
Sigma-Aldrich(India) B1686 BIO ≥98% (HPLC) 667463-62-9 25MG ₹64268.03 2022-06-14 Buy
Sigma-Aldrich(India) 361550 GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem BIO, CAS 667463-62-9, is a cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC?? = 5 nM). Maintains se 667463-62-9 1MG ₹17579.99 2022-06-14 Buy
Sigma-Aldrich(India) 361552 InSolution GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem The InSolution GSK-3 Inhibitor IX, also referenced under CAS 667463-62-9, controls the biological activity of GSK-3. This small molecule/inhibitor is 667463-62-9 500μG ₹11880.01 2022-06-14 Buy
Sigma-Aldrich(India) 361550 GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem BIO, CAS 667463-62-9, is a cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC?? = 5 nM). Maintains se 667463-62-9 10MG ₹58590 2022-06-14 Buy
Product number Packaging Price Buy
B1686 5MG ₹16421.53 Buy
B1686 25MG ₹64268.03 Buy
361550 1MG ₹17579.99 Buy
361552 500μG ₹11880.01 Buy
361550 10MG ₹58590 Buy

BIO Chemical Properties,Uses,Production

Description

BIO is a cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK3α/β (IC50 = 5 nM). Its specificity has been tested against various cyclin-dependent kinases (CDKs) (IC50s = 83, 300, 320, and 10,000 nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respectively). BIO was also tested for its specificity towards many other commonly studied kinases (IC50 ≥10 μM), including MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK. Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency in human and mouse embryonic stem cells (ESCs). BIO is reported to maintain self-renewal in human and mouse ESCs as well as induce the differentiation of neonatal cardiomyocytes.

Uses

6-bromoindirubin-3′-oxime (BIO) has been used:

  • in MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) cell proliferation assay
  • as a medium supplement in embryonic stem cells (ESCs)
  • for the inhibition of glycogen synthase kinase 3 β (GSK-3β) in human dermal papilla cells (hDPCs)

General Description

A cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Specificity was confirmed using various Cdk′s (IC50 = 83 nM for Cdk5/p25, 300 nM for Cdk2/cyclin A, 320 nM for Cdk1/cyclin B, and 10 μM for Cdk4/cyclin D1), MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK (IC50 ≥ 10 μM). Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency of human and murine embryonic stem cells (ESCs).

Biological Activity

Potent and selective, ATP-competitive glycogen synthase kinase-3 (GSK-3) inhibitor (IC 50 values are 5, 83, 300, 320 and > 10 000 nM at GSK-3, CDK5/p25, CDK2/cyclin A, CDK1/cyclin B and other common kinases respectively). Maintains self-renewal and pluripotency in embryonic stem cells via activation of the Wnt signaling pathway in vitro .

BIO Preparation Products And Raw materials

Raw materials

Preparation Products

BIO Suppliers

Global( 124)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29900 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD. +86-021-61551413 +8618813727289 China 5738 58 Inquiry
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd +86-86-22-87899925 +86-8618522618860 China 694 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26165 58 Inquiry
Supplier Advantage
A.J Chemicals 58
TCI Chemicals (India) Pvt. Ltd. 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
BOC Sciences 58
Chongqing Chemdad Co., Ltd 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58

BIO Spectrum

BIO(667463-62-9)1HNMR

667463-62-9(BIO)Related Search:

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2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE Nicardipine hydrochloride CHOLESTEROL ESTERASE FARNESENE Ethylamine
ESTETROL (-)-Varitriol
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2H-Indol-2-one, 6-broMo-3-[(3E)-1,3-dihydro-3-(hydroxyiMino)-2H-indol-2-ylidene]-1,3-dihydro-, (3Z)- 6BIO 6-bromoindirubin-3-oxime GSK3 Inhibitor IX1 BIO(GSK-3 Inhibitor IX BIO (SM04554) InSolution? GSK-3 Inhibitor IX (2E,3E)-6'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem InSolution GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem GSK-3 Inhibitor IX (BIO) CS-1934 (2'Z,3'E)-6-Bromoindirubin-3'-oxim BIO - GSK-3 inhibitor IX | 6-Bromoindirubin-3'-oxime GSK 3 Inhibitor IX (MLS 2052,6BIO) GSK 3 Inhibitor IX (6-Bromoindirubin-3'-oxime GSK 3 INHIBITOR IX (6-BROMOINDIRUBIN-3'-OXIME; BIO) 6BIO;6-BIO;GSK 3 IX;GSK 3 INHIBITOR IX;MLS 2052;MLS2052;GSK-3 INHIBITOR IX; 6-BROMOINDIRUBIN-3-OXIME GSK 3 IX MLS 2052 MLS2052 (2'Z,3'E)-6-Bromoindirubin-3'-oxime > Z E BIO USP/EP/BP MLS-2052 (GSK-3 Inhibitor IX (2Z,3E)-6'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one GSK 3 Inhibitor IX,Cyclin dependent kinase,Apoptosis,Inhibitor,Glycogen synthase kinase-3,CDK,MLS2052,Glycogen synthase kinase 3,MLS-2052,GSK-3,inhibit (2'Z,3'E)-6-Bromoindirubin-3'-oxime (2Z,3E)-6'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one 667463-62-9 C16H10BrN3O6 Inhibitors Intracellular Signaling Akt mTOR PI3K