BIO
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- ₹6500 - ₹64268.03
- Product name: BIO
- CAS: 667463-62-9
- MF: C16H10BrN3O2
- MW: 356.17
- EINECS:
- MDL Number:MFCD08705318
- Synonyms:2H-Indol-2-one, 6-broMo-3-[(3E)-1,3-dihydro-3-(hydroxyiMino)-2H-indol-2-ylidene]-1,3-dihydro-, (3Z)-;6BIO;6-bromoindirubin-3-oxime;GSK3 Inhibitor IX1;BIO(GSK-3 Inhibitor IX;BIO (SM04554);InSolution? GSK-3 Inhibitor IX ;(2E,3E)-6'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one
7 prices
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Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 1MG
- 10MG
- 500μG
- 5MG
- 25MG
- ManufacturerTCI Chemicals (India)
- Product numberB4006
- Product description(2'Z,3'E)-6-Bromoindirubin-3'-oxime
- Packaging5MG
- Price₹6500
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberB4006
- Product description(2'Z,3'E)-6-Bromoindirubin-3'-oxime
- Packaging25MG
- Price₹35500
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number361552
- Product descriptionInSolution GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem The InSolution GSK-3 Inhibitor IX, also referenced under CAS 667463-62-9, controls the biological activity of GSK-3. This small molecule/inhibitor is
- Packaging500μG
- Price₹11880.01
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberB1686
- Product descriptionBIO ≥98% (HPLC)
- Packaging5MG
- Price₹16421.53
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number361550
- Product descriptionGSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem BIO, CAS 667463-62-9, is a cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC?? = 5 nM). Maintains se
- Packaging1MG
- Price₹17579.99
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number361550
- Product descriptionGSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem BIO, CAS 667463-62-9, is a cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC?? = 5 nM). Maintains se
- Packaging10MG
- Price₹58590
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberB1686
- Product descriptionBIO ≥98% (HPLC)
- Packaging25MG
- Price₹64268.03
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | B4006 | (2'Z,3'E)-6-Bromoindirubin-3'-oxime | 5MG | ₹6500 | 2022-05-26 | Buy |
| TCI Chemicals (India) | B4006 | (2'Z,3'E)-6-Bromoindirubin-3'-oxime | 25MG | ₹35500 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | 361552 | InSolution GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem The InSolution GSK-3 Inhibitor IX, also referenced under CAS 667463-62-9, controls the biological activity of GSK-3. This small molecule/inhibitor is | 500μG | ₹11880.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B1686 | BIO ≥98% (HPLC) | 5MG | ₹16421.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 361550 | GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem BIO, CAS 667463-62-9, is a cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC?? = 5 nM). Maintains se | 1MG | ₹17579.99 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 361550 | GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem BIO, CAS 667463-62-9, is a cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC?? = 5 nM). Maintains se | 10MG | ₹58590 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B1686 | BIO ≥98% (HPLC) | 25MG | ₹64268.03 | 2022-06-14 | Buy |
Properties
Melting point :300°C(lit.)
Boiling point :554.3±50.0 °C(Predicted)
Density :1.80±0.1 g/cm3(Predicted)
RTECS :NM3241900
storage temp. :2-8°C
solubility :DMSO: >5 mg/mL
form :solid
pka :9.56±0.20(Predicted)
color :dark red
Sensitive :Air & Light Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Boiling point :554.3±50.0 °C(Predicted)
Density :1.80±0.1 g/cm3(Predicted)
RTECS :NM3241900
storage temp. :2-8°C
solubility :DMSO: >5 mg/mL
form :solid
pka :9.56±0.20(Predicted)
color :dark red
Sensitive :Air & Light Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Safety Information
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Description
BIO is a cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK3α/β (IC50 = 5 nM). Its specificity has been tested against various cyclin-dependent kinases (CDKs) (IC50s = 83, 300, 320, and 10,000 nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respectively). BIO was also tested for its specificity towards many other commonly studied kinases (IC50 ≥10 μM), including MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK. Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency in human and mouse embryonic stem cells (ESCs). BIO is reported to maintain self-renewal in human and mouse ESCs as well as induce the differentiation of neonatal cardiomyocytes.More related product prices
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